Chromatin remodeling by the small RNA machinery in mammalian cells

Short hairpin RNA induces methylation of hepatitis B virus covalently closed circular DNA in human hepatoma cells

(2013) Hyun Kyung Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

(2013) Jeannie T. Lee et al.   CELL

Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals

(2013) K. Okamura et al.   GENES & DEVELOPMENT

Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA

(2013) A. Singh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Promoter RNA links transcriptional regulation of inflammatory pathway genes

(2013) Masayuki Matsui et al.   NUCLEIC ACIDS RESEARCH

Targeted induction of endogenousNKX3-1by small activating RNA inhibits prostate tumor growth

(2013) Shancheng Ren et al.   PROSTATE

Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells

(2013) Vera Huang et al.   PLoS Genetics

Induction ofNANOGexpression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation

(2012) Xiaoling Wang et al.   BIOCHEMICAL JOURNAL

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

(2012) G. Zardo et al.   BLOOD

microRNA involvement in human cancer

(2012) M. V. Iorio et al.   CARCINOGENESIS

Slicing-Independent RISC Activation Requires the Argonaute PAZ Domain

(2012) Shuo Gu et al.   CURRENT BIOLOGY

Naturally occurring endo-siRNA silences LINE-1 retrotransposons in human cells through DNA methylation

(2012) Long Chen et al.   Epigenetics

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

Argonaute proteins couple chromatin silencing to alternative splicing

(2012) Maya Ameyar-Zazoua et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2

(2012) Sumanth Polikepahad et al.   NUCLEIC ACIDS RESEARCH

Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells

(2012) Guosong Jiang et al.   PLoS One

miRNA goes nuclear

(2012) Vera Huang et al.   RNA Biology

RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function

(2011) N. Moshkovich et al.   GENES & DEVELOPMENT

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

Characterization of an HIV-Targeted Transcriptional Gene-Silencing RNA in Primary Cells

(2011) Anne-Marie W. Turner et al.   HUMAN GENE THERAPY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

(2011) Filippo M. Cernilogar et al.   NATURE

Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing

(2011) Jing Liu et al.   NUCLEIC ACIDS RESEARCH

Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells

(2011) Chantelle L. Ahlenstiel et al.   NUCLEIC ACIDS RESEARCH

Upregulation of Cyclin B1 by miRNA and its implications in cancer

(2011) Vera Huang et al.   NUCLEIC ACIDS RESEARCH

Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

(2011) Scott T. Younger et al.   NUCLEIC ACIDS RESEARCH

The multifaceted small RNAs

(2011) Long-Cheng Li   RNA Biology

Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus

(2011) T. Watanabe et al.   SCIENCE

Small RNA and transcriptional upregulation

(2011) Victoria Portnoy et al.   Wiley Interdisciplinary Reviews-RNA

Activation of LDL Receptor Expression by Small RNAs Complementary to a Noncoding Transcript that Overlaps the LDLR Promoter

(2010) Masayuki Matsui et al.   CHEMISTRY & BIOLOGY

Defining Features and Exploring Chemical Modifications to Manipulate RNAa Activity

(2010) Robert F. Place et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Characterization of the RNA content of chromatin

(2010) T. Mondal et al.   GENOME RESEARCH

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Transcriptional regulation by small RNAs at sequences downstream from 3′ gene termini

(2010) Xuan Yue et al.   Nature Chemical Biology

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

(2010) Yongjun Chu et al.   NUCLEIC ACIDS RESEARCH

Deep Sequencing of Human Nuclear and Cytoplasmic Small RNAs Reveals an Unexpectedly Complex Subcellular Distribution of miRNAs and tRNA 3′ Trailers

(2010) Jian-You Liao et al.   PLoS One

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Predicting potential miRNA target sites within gene promoters

(2009) Scott T. Younger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transcriptional inhibition of Hoxd4 expression by noncoding RNAs in human breast cancer cells

(2009) Yuliang Tan et al.   BMC MOLECULAR BIOLOGY

Efficient Regulation of VEGF Expression by Promoter-Targeted Lentiviral shRNAs Based on Epigenetic Mechanism

(2009) Mikko P. Turunen et al.   CIRCULATION RESEARCH

Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells

(2009) Sara Napoli et al.   EMBO JOURNAL

Essential and overlapping functions for mammalian Argonautes in microRNA silencing

(2009) H. Su et al.   GENES & DEVELOPMENT

Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription

(2009) Makoto Yamagishi et al.   MICROBES AND INFECTION

The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs

(2009) Alain Jacquier   NATURE REVIEWS GENETICS

Control of alternative splicing through siRNA-mediated transcriptional gene silencing

(2009) Mariano Alló et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins

(2009) Bingbing Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells

(2009) Peter G. Hawkins et al.   NUCLEIC ACIDS RESEARCH

A Requirement for DICER to Maintain Full Promoter CpG Island Hypermethylation in Human Cancer Cells

(2008) A. H. Ting et al.   CANCER RESEARCH

Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region

(2008) Kazuo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells

(2008) Thomas Ohrt et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA