Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2022.888424
Keywords
tRNA fragments; RNA therapeutics; translation inhibition; post-transcriptional regulation of gene expression; RNA silencing
Categories
Funding
- NIH [R01 AR067712]
- NIH NCI [F30 CA254134]
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tRNA-derived small RNAs tRFs and tiRs have diverse functions and potential applications in the field of small RNA therapeutics.
tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gene silencing, and finally, to translational regulation. The length distribution, sequence diversity, and multifaceted functions of tRFs and tiRs positions them as attractive new models for small RNA therapeutics. In this review, we will discuss the principles of tRF biogenesis and function in order to highlight their therapeutic potential.
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