Polysaccharides’ Structures and Functions in Biofilm Architecture of Antimicrobial-Resistant (AMR) Pathogens

A methodological review on the characterization of microalgal biofilm and its extracellular polymeric substances

(2022) Yi Tong Cheah et al.   JOURNAL OF APPLIED MICROBIOLOGY

The Chemical Structure Properties and Promoting Biofilm Activity of Exopolysaccharide Produced by Shigella flexneri

(2022) Yinglong Song et al.   Frontiers in Microbiology

Contribution of Pseudomonas aeruginosa Exopolysaccharides Pel and Psl to Wound Infections

(2022) Derek Fleming et al.   Frontiers in Cellular and Infection Microbiology

The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine

(2022) François Le Mauff et al.   Communications Biology

The biofilm life cycle: expanding the conceptual model of biofilm formation

(2022) Karin Sauer et al.   NATURE REVIEWS MICROBIOLOGY

Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies

(2021) Laura K. Jennings et al.   Cell Reports

Conservative production of galactosaminogalactan in Metarhizium is responsible for appressorium mucilage production and topical infection of insect hosts

(2021) Lijuan Mei et al.   PLoS Pathogens

Biofilm patterns in gram-positive and gram-negative bacteria

(2021) Rohit Ruhal et al.   MICROBIOLOGICAL RESEARCH

Alginate Lyase Guided Silver Nanocomposites for Eradicating Pseudomonas aeruginosa from Lungs

(2020) Bing Wan et al.   ACS Applied Materials & Interfaces

Synthesis and Structural Analysis of Aspergillus fumigatus Galactosaminogalactans Featuring α‐Galactose, α‐Galactosamine and α‐ N ‐Acetyl Galactosamine Linkages

(2020) Yongzhen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond Risk: Bacterial Biofilms and Their Regulating Approaches

(2020) Musa Hassan Muhammad et al.   Frontiers in Microbiology

Extracellular DNA builds and interacts with vibrio polysaccharide in the biofilm matrix formed by Vibrio cholerae

(2020) Amol Kanampalliwar et al.   Environmental Microbiology Reports

Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles

(2020) Yu Jiang et al.   Microorganisms

Glycoside hydrolase (PelAh) immobilization prevents Pseudomonas aeruginosa biofilm formation on cellulose-based wound dressing

(2020) Magdalena Szymańska et al.   CARBOHYDRATE POLYMERS

Alginate Lyase Immobilized Chitosan Nanoparticles of Ciprofloxacin for the improved antimicrobial activity against the Biofilm associated mucoid P. aeruginosa infection in Cystic Fibrosis

(2019) Krishna Kumar Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity

(2019) Matthew J. Pestrak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases

(2019) François Le Mauff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanoparticle–Biofilm Interactions: The Role of the EPS Matrix

(2019) Stephanie Fulaz et al.   TRENDS IN MICROBIOLOGY

Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms

(2019) Natalie C. Bamford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Twofold enhanced dispersin B activity by N-terminal fusion to silver-binding peptide for biofilm eradication

(2018) Kuan-Jung Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose

(2018) Wiriya Thongsomboon et al.   SCIENCE

Viscoelastic properties of Pseudomonas aeruginosa variant biofilms

(2018) Erin S. Gloag et al.   Scientific Reports

PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms

(2018) Dustin J. Little et al.   PLoS Pathogens

Integration of electron microscopy and solid-state NMR analysis for new views and compositional parameters of Aspergillus fumigatus biofilms

(2018) Courtney Reichhardt et al.   MEDICAL MYCOLOGY

Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion

(2017) Christopher J. Jones et al.   mBio

The Rcs-Regulated Colanic Acid Capsule Maintains Membrane Potential in Salmonella enterica serovar Typhimurium

(2017) Jasmine M. Pando et al.   mBio

Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms

(2017) Jiunn CN Fong et al.   eLife

Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption

(2017) Valerie A. Ray et al.   Scientific Reports

Quantification of biofilm exopolysaccharides using an in situ assay with periodic acid–Schiff reagent

(2016) I. Randrianjatovo-Gbalou et al.   ANALYTICAL BIOCHEMISTRY

Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds

(2016) Derek Fleming et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hyaluronan Modulation Impacts Staphylococcus aureus Biofilm Infection

(2016) Carolyn B. Ibberson et al.   INFECTION AND IMMUNITY

Escherichia colibiofilm: development and therapeutic strategies

(2016) G. Sharma et al.   JOURNAL OF APPLIED MICROBIOLOGY

Xanthan Pyruvilation Is Essential for the Virulence ofXanthomonas campestrispv.campestris

(2016) María Isabel Bianco et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Biofilms: an emergent form of bacterial life

(2016) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Evaluation of Mannosidase and Trypsin Enzymes Effects on Biofilm Production of Pseudomonas aeruginosa Isolated from Burn Wound Infections

(2016) Maryam Banar et al.   PLoS One

Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation

(2016) Mark J. Lee et al.   mBio

The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase

(2016) Wafi Siala et al.   Nature Communications

Vibrio cholerae Biofilms and Cholera Pathogenesis

(2016) Anisia J. Silva et al.   PLoS Neglected Tropical Diseases

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

(2016) Sirijan Santajit et al.   Biomed Research International

Enzymatic degradation of in vitro Staphylococcus aureus biofilms supplemented with human plasma

(2016) Nancy Millenbaugh et al.   Infection and Drug Resistance

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

(2016) P. Baker et al.   Science Advances

Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

(2015) Oana Ciofu et al.   ADVANCED DRUG DELIVERY REVIEWS

A Molecular Description of Cellulose Biosynthesis

(2015) Joshua T. McNamara et al.   Annual Review of Biochemistry

Biofilm, pathogenesis and prevention—a journey to break the wall: a review

(2015) Priya Gupta et al.   ARCHIVES OF MICROBIOLOGY

Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of theBacillus subtilisBiofilm Matrix

(2015) Damien Roux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bottom-up and top-down solid-state NMR approaches for bacterial biofilm matrix composition

(2015) Lynette Cegelski   JOURNAL OF MAGNETIC RESONANCE

Enhancing the stability and antibiofilm activity of DspB by immobilization on carboxymethyl chitosan nanoparticles

(2015) Yulong Tan et al.   MICROBIOLOGICAL RESEARCH

Ciprofloxacin plus erythromycin or ambroxol ameliorates endotracheal tube-associated Pseudomonas aeruginosa biofilms in a rat model

(2015) Chen Cheng et al.   PATHOLOGY RESEARCH AND PRACTICE

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in thePseudomonas aeruginosabiofilm matrix

(2015) Laura K. Jennings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditions Associated with the Cystic Fibrosis Defect Promote ChronicPseudomonas aeruginosaInfection

(2014) Benjamin J. Staudinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunological evaluation of an alginate-based conjugate as a vaccine candidate againstPseudomonas aeruginosa

(2014) Ali Farjah et al.   APMIS

Vaccines forPseudomonas aeruginosa: a long and winding road

(2014) Gregory P Priebe et al.   Expert Review of Vaccines

A Polysaccharide Virulence Factor of a Human Fungal Pathogen Induces Neutrophil Apoptosis via NK Cells

(2014) P. Robinet et al.   JOURNAL OF IMMUNOLOGY

The role of pgaC in Klebsiella pneumoniae virulence and biofilm formation

(2014) Kuang-Ming Chen et al.   MICROBIAL PATHOGENESIS

Structural Characterization of the Extracellular Polysaccharide from Vibrio cholerae O1 El-Tor

(2014) Fitnat Yildiz et al.   PLoS One

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

(2014) A. DiGiandomenico et al.   Science Translational Medicine

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

(2014) Mark S. Gresnigt et al.   PLoS Pathogens

The role of bacterial biofilms in chronic infections

(2013) Thomas Bjarnsholt   APMIS

Epitope Mapping of Monoclonal Antibodies using Synthetic Oligosaccharides Uncovers Novel Aspects of Immune Recognition of the Psl Exopolysaccharide ofPseudomonas aeruginosa

(2013) Huiqing Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

A spider web strategy of type IV pili-mediated migration to build a fibre-like Psl polysaccharide matrix inPseudomonas aeruginosabiofilms

(2013) Shiwei Wang et al.   ENVIRONMENTAL MICROBIOLOGY

The virulence of Streptococcus mutans and the ability to form biofilms

(2013) W. Krzyściak et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Novel Strategies for the Prevention and Treatment of Biofilm Related Infections

(2013) Meng Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PelA Deacetylase Activity Is Required for Pel Polysaccharide Synthesis in Pseudomonas aeruginosa

(2013) K. M. Colvin et al.   JOURNAL OF BACTERIOLOGY

Solid-state NMR for bacterial biofilms

(2013) Courtney Reichhardt et al.   MOLECULAR PHYSICS

Purification and Characterization of Biofilm-Associated EPS Exopolysaccharides from ESKAPE Organisms and Other Pathogens

(2013) Patrick M. Bales et al.   PLoS One

The Extracellular Matrix Component Psl Provides Fast-Acting Antibiotic Defense in Pseudomonas aeruginosa Biofilms

(2013) Nicole Billings et al.   PLoS Pathogens

Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System

(2013) Fabrice N. Gravelat et al.   PLoS Pathogens

Staphylococcal Infections: Mechanisms of Biofilm Maturation and Detachment as Critical Determinants of Pathogenicity

(2012) Michael Otto   Annual Review of Medicine

Alginate Lyase Exhibits Catalysis-Independent Biofilm Dispersion and Antibiotic Synergy

(2012) John W. Lamppa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Model for β-1,6-N-acetylglucosamine oligomer hydrolysis catalysed by DispersinB, a biofilm degrading enzyme

(2012) Erika Fazekas et al.   CARBOHYDRATE RESEARCH

Molecular Basis of In Vivo Biofilm Formation by Bacterial Pathogens

(2012) Hwang-Soo Joo et al.   CHEMISTRY & BIOLOGY

The roles of biofilm matrix polysaccharide Psl in mucoidPseudomonas aeruginosabiofilms

(2012) Luyan Ma et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening

(2012) Antonio DiGiandomenico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa

(2012) Y. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Candida Biofilm-Induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance

(2012) Heather T. Taff et al.   PLoS Pathogens

Periodic acid–Schiff’s reagent assay for carbohydrates in a microtiter plate format

(2011) Michelle Kilcoyne et al.   ANALYTICAL BIOCHEMISTRY

Characterization of the Poly-β-1,6-N-Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms

(2011) Nandadeva Yakandawala et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Role of Exopolysaccharides in Pseudomonas aeruginosa Biofilm Formation and Architecture

(2011) Aamir Ghafoor et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization

(2011) Meenu Mishra et al.   CELLULAR MICROBIOLOGY

Distinct roles of extracellular polymeric substances in Pseudomonas aeruginosa biofilm development

(2011) Liang Yang et al.   ENVIRONMENTAL MICROBIOLOGY

The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix

(2011) Kelly M. Colvin et al.   ENVIRONMENTAL MICROBIOLOGY

Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood

(2011) Davide Paleari et al.   Expert Opinion on Drug Discovery

Poly-N-Acetyl-β-(1-6)-Glucosamine Is a Target for Protective Immunity against Acinetobacter baumannii Infections

(2011) Leticia V. Bentancor et al.   INFECTION AND IMMUNITY

Direct Evaluation of Pseudomonas aeruginosa Biofilm Mediators in a Chronic Infection Model

(2011) Matthew S. Byrd et al.   INFECTION AND IMMUNITY

Staphylococcus epidermidis Uses Distinct Mechanisms of Biofilm Formation To Interfere with Phagocytosis and Activation of Mouse Macrophage-Like Cells 774A.1

(2011) Nina N. Schommer et al.   INFECTION AND IMMUNITY

Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

(2011) Michael J. Franklin et al.   Frontiers in Microbiology

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Impact of Alginate Overproduction on Attachment and Biofilm Architecture of a Supermucoid Pseudomonas aeruginosa Strain

(2009) I. D. Hay et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sampling methods for NMR-based metabolomics ofStaphylococcus aureus

(2009) Xiao-He Wu et al.   Biotechnology Journal

In vivobiofilm composition ofAspergillus fumigatus

(2009) Céline Loussert et al.   CELLULAR MICROBIOLOGY

Synthetic  -(1->6)-Linked N-Acetylated and Nonacetylated Oligoglucosamines Used To Produce Conjugate Vaccines for Bacterial Pathogens

(2009) M. L. Gening et al.   INFECTION AND IMMUNITY

Importance of DNase and alginate lyase for enhancing free and liposome encapsulated aminoglycoside activity against Pseudomonas aeruginosa

(2009) M. Alipour et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Genetic and biochemical analyses of thePseudomonas aeruginosaPsl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production

(2009) Matthew S. Byrd et al.   MOLECULAR MICROBIOLOGY

Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix

(2009) Luyan Ma et al.   PLoS Pathogens

Aspergillus fumigatus Forms Biofilms with Reduced Antifungal Drug Susceptibility on Bronchial Epithelial Cells

(2008) M. J. Seidler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Solution structure of peptide AG4 used to form silver nanoparticles

(2008) Eunjung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Ambroxol on Alginate of Mature Pseudomonas aeruginosa Biofilms

(2008) Fang Li et al.   CURRENT MICROBIOLOGY

Involvement of a Novel Efflux System in Biofilm-Specific Resistance to Antibiotics

(2008) L. Zhang et al.   JOURNAL OF BACTERIOLOGY

Role of hyaluronidase in Streptococcus intermedius biofilm

(2008) D. Pecharki et al.   MICROBIOLOGY-SGM