Vaccines forPseudomonas aeruginosa: a long and winding road

IL-17 Is a Critical Component of Vaccine-Induced Protection against Lung Infection by Lipopolysaccharide-Heterologous Strains of Pseudomonas aeruginosa

(2014) G. P. Priebe et al.   JOURNAL OF IMMUNOLOGY

A Th17- and Th2-skewed Cytokine Profile in Cystic Fibrosis Lungs Represents a Potential Risk Factor forPseudomonas aeruginosaInfection

(2013) Kerstin Tiringer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Update in Cystic Fibrosis 2012

(2013) Christopher H. Goss et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RGD capsid modification enhances mucosal protective immunity of a non-human primate adenovirus vector expressingPseudomonas aeruginosa OprF

(2013) A. Krause et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Adenovirus-Based Vaccine with Epitopes Incorporated in Novel Fiber Sites to Induce Protective Immunity against Pseudomonas aeruginosa

(2013) Anurag Sharma et al.   PLoS One

Th17-stimulating Protein Vaccines Confer Protection againstPseudomonas aeruginosaPneumonia

(2012) Weihui Wu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa

(2012) Bruno François et al.   CRITICAL CARE MEDICINE

40 years on: have we finally got a vaccine forPseudomonas aeruginosa?

(2012) Stefan Worgall   Future Microbiology

Topical Neutralization of Interleukin-17 during Experimental Pseudomonas aeruginosa Corneal Infection Promotes Bacterial Clearance and Reduces Pathology

(2012) Tanweer S. Zaidi et al.   INFECTION AND IMMUNITY

Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010

(2012) Dawn M. Sievert et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening

(2012) Antonio DiGiandomenico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Collaboration Between Macrophages and Vaccine-Induced CD4+ T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia

(2012) Akinobu Kamei et al.   JOURNAL OF INFECTIOUS DISEASES

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota

(2012) A. F. Goddard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serial Analysis of the Gut and Respiratory Microbiome in Cystic Fibrosis in Infancy: Interaction between Intestinal and Respiratory Tracts and Impact of Nutritional Exposures

(2012) J. C. Madan et al.   mBio

The Th17 Pathway in Cystic Fibrosis Lung Disease

(2011) Hui-Leng Tan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Recent developments for Pseudomonas vaccines

(2011) Anurag Sharma et al.   Human vaccines & immunotherapeutics

Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal Immunity

(2011) Kong Chen et al.   IMMUNITY

Efficacy of a Conjugate Vaccine Containing Polymannuronic Acid and Flagellin against Experimental Pseudomonas aeruginosa Lung Infection in Mice

(2011) Victoria L. Campodónico et al.   INFECTION AND IMMUNITY

Anti-Pseudomonas aeruginosa serotype O11 LPS immunoglobulin M monoclonal antibody panobacumab (KBPA101) confers protection in a murine model of acute lung infection

(2011) T. Secher et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumonia

(2011) Q. Lu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Culture Enriched Molecular Profiling of the Cystic Fibrosis Airway Microbiome

(2011) Christopher D. Sibley et al.   PLoS One

Multi-Functional Characteristics of the Pseudomonas aeruginosa Type III Needle-Tip Protein, PcrV; Comparison to Orthologs in other Gram-negative Bacteria

(2011) Hiromi Sato et al.   Frontiers in Microbiology

Western Trauma Association/Critical Decisions in Trauma: Operative Management of Adult Blunt Hepatic Trauma

(2011) Rosemary A. Kozar et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Preclinical In Vitro and In Vivo Characterization of the Fully Human Monoclonal IgM Antibody KBPA101 Specific for Pseudomonas aeruginosa Serotype IATS-O11

(2010) M. P. Horn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mucosal Vaccination with a Multivalent, Live-Attenuated Vaccine Induces Multifactorial Immunity againstPseudomonas aeruginosaAcute Lung Infection

(2010) Akinobu Kamei et al.   INFECTION AND IMMUNITY

(1,3)- -Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

(2010) P. Kankkunen et al.   JOURNAL OF IMMUNOLOGY

Utility of In Vivo Transcription Profiling for Identifying Pseudomonas aeruginosa Genes Needed for Gastrointestinal Colonization and Dissemination

(2010) Andrew Y. Koh et al.   PLoS One

OprF/I-vaccinated sera inhibit binding of human interferon-gamma to Pseudomonas aeruginosa

(2010) Bin Ding et al.   VACCINE

Pharmacokinetics and Safety Profile of the Human Anti-Pseudomonas aeruginosa Serotype O11 Immunoglobulin M Monoclonal Antibody KBPA-101 in Healthy Volunteers

(2009) H. Lazar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diagnosis and Management of Infectious Complications in Critically Ill Patients with Cancer

(2009) Raghukumar Thirumala et al.   CRITICAL CARE CLINICS

Population-Based Study of the Epidemiology and the Risk Factors for Pseudomonas aeruginosa Bloodstream Infection

(2009) M. D. Parkins et al.   INFECTION

Genome-Wide Study of Pseudomonas aeruginosa Outer Membrane Protein Immunogenicity Using Self-Assembling Protein Microarrays

(2009) W. R. Montor et al.   INFECTION AND IMMUNITY

A Fusion Protein Vaccine Containing OprF Epitope 8, OprI, and Type A and B Flagellins Promotes Enhanced Clearance of Nonmucoid Pseudomonas aeruginosa

(2009) E. T. Weimer et al.   INFECTION AND IMMUNITY

Inescapable Need for Neutrophils as Mediators of Cellular Innate Immunity to Acute Pseudomonas aeruginosa Pneumonia

(2009) A. Y. Koh et al.   INFECTION AND IMMUNITY

Intranasal Immunization Promotes Th17 Immune Responses

(2009) B. M. Zygmunt et al.   JOURNAL OF IMMUNOLOGY

Genetic and biochemical analyses of thePseudomonas aeruginosaPsl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production

(2009) Matthew S. Byrd et al.   MOLECULAR MICROBIOLOGY

Pseudomonas aeruginosa Population Structure Revisited

(2009) Jean-Paul Pirnay et al.   PLoS One

Immunization of young African green monkeys with OprF epitope 8–OprI–type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonasaeruginosa

(2009) Eric T. Weimer et al.   VACCINE

An Engineered Human Antibody Fab Fragment Specific for Pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activity

(2008) M. Baer et al.   INFECTION AND IMMUNITY

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Good effect of IgY againstPseudomonas aeruginosainfections in cystic fibrosis patients

(2008) Elin Nilsson et al.   PEDIATRIC PULMONOLOGY

Vaccines and immunotherapy against Pseudomonas aeruginosa

(2008) Gerd Döring et al.   VACCINE