PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms

PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation inPseudomonas aeruginosa

(2017) Lindsey S. Marmont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity

(2017) Brendan D. Snarr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria

(2016) Donald C. Sheppard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Translocation of a Biofilm-supporting Exopolysaccharide across the Bacterial Outer Membrane

(2016) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BcsZ inhibits biofilm phenotypes and promotes virulence by blocking cellulose production in Salmonella enterica serovar Typhimurium

(2016) Irfan Ahmad et al.   Microbial Cell Factories

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

(2016) P. Baker et al.   Science Advances

Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan inAspergillus fumigatus

(2015) Natalie C. Bamford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of thePseudomonas aeruginosaGlycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation

(2015) Perrin Baker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein BpsB Is a Poly-β-1,6-N-acetyl-d-glucosamine Deacetylase Required for Biofilm Formation inBordetella bronchiseptica

(2015) Dustin J. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of theBacillus subtilisBiofilm Matrix

(2015) Damien Roux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L isteria monocytogenes exopolysaccharide: origin, structure, biosynthetic machinery and c-di-GMP-dependent regulation

(2015) Volkan K. Köseoğlu et al.   MOLECULAR MICROBIOLOGY

Salmonellapromotes virulence by repressing cellulose production

(2015) Mauricio H. Pontes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic modifications of exopolysaccharides enhance bacterial persistence

(2015) Gregory B. Whitfield et al.   Frontiers in Microbiology

TheBordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing

(2014) Tridib Ganguly et al.   CELLULAR MICROBIOLOGY

Comparative Analyses of a Cystic Fibrosis Isolate of Bordetella bronchiseptica Reveal Differences in Important Pathogenic Phenotypes

(2014) Neelima Sukumar et al.   INFECTION AND IMMUNITY

The role of pgaC in Klebsiella pneumoniae virulence and biofilm formation

(2014) Kuang-Ming Chen et al.   MICROBIAL PATHOGENESIS

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Modification and periplasmic translocation of the biofilm exopolysaccharide poly- -1,6-N-acetyl-D-glucosamine

(2014) D. J. Little et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation

(2014) Perrin Baker et al.   PLoS Pathogens

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

(2013) C. Cywes-Bentley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Detection of Fitness Genes in Uropathogenic Escherichia coli during Systemic Infection

(2013) Sargurunathan Subashchandrabose et al.   PLoS Pathogens

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Combiningin situproteolysis and mass spectrometry to crystallizeEscherichia coliPgaB

(2012) Dustin J. Little et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Model for β-1,6-N-acetylglucosamine oligomer hydrolysis catalysed by DispersinB, a biofilm degrading enzyme

(2012) Erika Fazekas et al.   CARBOHYDRATE RESEARCH

Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

(2012) Samuel Steiner et al.   EMBO JOURNAL

The Structure- and Metal-dependent Activity ofEscherichia coliPgaB Provides Insight into the Partial De-N-acetylation of Poly-β-1,6-N-acetyl-d-glucosamine

(2012) Dustin J. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production inPseudomonas aeruginosa

(2012) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria

(2012) J.C. Whitney et al.   TRENDS IN MICROBIOLOGY

Characterization of the Poly-β-1,6-N-Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms

(2011) Nandadeva Yakandawala et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis of β-(1→6)-linked N-acetyl-d-glucosamine oligosaccharide substrates and their hydrolysis by Dispersin B

(2011) Anikó Fekete et al.   CARBOHYDRATE RESEARCH

Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

(2011) Tara E. Sutherland et al.   CHEMISTRY & BIOLOGY

Apo- and Cellopentaose-bound Structures of the Bacterial Cellulose Synthase Subunit BcsZ

(2011) Olga Mazur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular DNA Is Essential for Maintaining Bordetella Biofilm Integrity on Abiotic Surfaces and in the Upper Respiratory Tract of Mice

(2011) Matt S. Conover et al.   PLoS One

FHA-Mediated Cell-Substrate and Cell-Cell Adhesions Are Critical for Bordetella pertussis Biofilm Formation on Abiotic Surfaces and in the Mouse Nose and the Trachea

(2011) Diego O. Serra et al.   PLoS One

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

CAZymes Analysis Toolkit (CAT): Web service for searching and analyzing carbohydrate-active enzymes in a newly sequenced organism using CAZy database

(2010) Byung H Park et al.   GLYCOBIOLOGY

Analysis of HmsH and its role in plague biofilm formation

(2010) A. Abu Khweek et al.   MICROBIOLOGY-SGM

The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin

(2010) Matt S. Conover et al.   MOLECULAR MICROBIOLOGY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The pgaABCD Locus of Acinetobacter baumannii Encodes the Production of Poly- -1-6-N-Acetylglucosamine, Which Is Critical for Biofilm Formation

(2009) A. H. K. Choi et al.   JOURNAL OF BACTERIOLOGY

Loss of a Biofilm-Inhibiting Glycosyl Hydrolase during the Emergence of Yersinia pestis

(2008) D. L. Erickson et al.   JOURNAL OF BACTERIOLOGY

Roles of pgaABCD Genes in Synthesis, Modification, and Export of the Escherichia coli Biofilm Adhesin Poly- -1,6-N-Acetyl-D-Glucosamine

(2008) Y. Itoh et al.   JOURNAL OF BACTERIOLOGY