A review on CRISPR/Cas: a versatile tool for cancer screening, diagnosis, and clinic treatment

Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression

(2023) Xinyue Lei et al.   EMBO REPORTS

Craspase: A novel CRISPR/Cas dual gene editor

(2023) George Huo et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Association of programmed cell death 1 (PD-1) gene polymorphism (rs10204525) with COVID-19 severity and mortality: A case-control study in the Iranian population

(2023) Ensie Sadat Mirsharif et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Evidence of Association between CTLA-4 Gene Polymorphisms and Colorectal Cancers in Saudi Patients

(2023) Nouf Al-Harbi et al.   Genes

Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice

(2023) Wen Bu et al.   Science Advances

Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction

(2023) Somaya A. Abdel-Rahman et al.   SLAS Discovery

Generation of reproductive transgenic pigs of a CRISPR‐Cas9‐based oncogene‐inducible system by somatic cell nuclear transfer

(2022) Kiyoung Eun et al.   Biotechnology Journal

Cytosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL

(2022) Caroline Diorio et al.   BLOOD

Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon

(2022) Julia Matas et al.   CANCER RESEARCH

Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex

(2022) Kazuki Kato et al.   CELL

Animal models of cystic fibrosis in the era of highly effective modulator therapies

(2022) Barbara R. Grubb et al.   CURRENT OPINION IN PHARMACOLOGY

Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling

(2022) Shuiliang Yu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Functional Polymorphism in Pak1–3′ Untranslated Region Alters Skin Tumor Susceptibility by Alternative Polyadenylation

(2022) Kazuhiro Okumura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Review of selected animal models for respiratory coronavirus infection and its application in drug research

(2022) Shengle Qin et al.   JOURNAL OF MEDICAL VIROLOGY

Inhibition of NOS1 promotes the interferon response of melanoma cells

(2022) Xi Chen et al.   Journal of Translational Medicine

MicroRNAs and drug resistance in colorectal cancer with special focus on 5-fluorouracil

(2022) Fahima Danesh Pouya et al.   MOLECULAR BIOLOGY REPORTS

CRISPR based therapeutics: a new paradigm in cancer precision medicine

(2022) Sumit Das et al.   Molecular Cancer

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing

(2022) Alexander Dimitri et al.   Molecular Cancer

Olfactory Receptor OR2H1 is an effective target for CAR T cells in human epithelial tumors

(2022) Alexandra L. Martin et al.   MOLECULAR CANCER THERAPEUTICS

Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors

(2022) Yafeng Wang et al.   Nature Communications

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

(2022) Ida Höijer et al.   Nature Communications

CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells

(2022) Pia Sommerkamp et al.   Scientific Reports

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

(2022) Johanna Michl et al.   Cell Reports

Effect of CRISPR/Cas9-Edited PD-1/PD-L1 on Tumor Immunity and Immunotherapy

(2022) Yanxin Xu et al.   Frontiers in Immunology

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells

(2022) Jonas Kath et al.   Molecular Therapy-Methods & Clinical Development

HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms

(2022) Aditi Jain et al.   Cancers

Experimental models for ovarian cancer research

(2022) Sum In Tsang et al.   EXPERIMENTAL CELL RESEARCH

Craspase is a CRISPR RNA-guided, RNA-activated protease

(2022) Chunyi Hu et al.   SCIENCE

Non-viral precision T cell receptor replacement for personalized cell therapy

(2022) Susan P. Foy et al.   NATURE

Target RNA-guided protease activity in type III-E CRISPR–Cas system

(2022) Xiaoshen Wang et al.   NUCLEIC ACIDS RESEARCH

CRISPR base editing applications for identifying cancer-driving mutations

(2021) Martin Pal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Breast cancer radioresistance may be overcome by osteopontin gene knocking out with CRISPR/Cas9 technique

(2021) R.G. Behbahani et al.   Cancer Radiotherapie

A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation

(2021) Yuan-Hung Lo et al.   Cancer Discovery

Development and application of sensitive, specific and rapid CRISPR‐Cas13‐based diagnosis

(2021) David Gao et al.   JOURNAL OF MEDICAL VIROLOGY

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

(2021) Jonathan Y. Hsu et al.   Nature Communications

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy

(2021) Weiqin Jiang et al.   Frontiers in Immunology

CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells

(2021) Raoud Marayati et al.   CANCER GENE THERAPY

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement

(2021) Chao Li et al.   Journal of Zhejiang University-SCIENCE B

CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin

(2021) Chun Cheng et al.   ONCOGENE

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

(2021) Pengpeng Liu et al.   Nature Communications

CAR-T cell therapy: current limitations and potential strategies

(2021) Robert C. Sterner et al.   Blood Cancer Journal

Overexpression of CRABP2 inhibits dexamethasone-induced apoptosis in human osteoblast cells

(2021) Haiping Zhang et al.   Journal of Orthopaedic Surgery and Research

A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior

(2021) Marie François et al.   BIOLOGICAL PSYCHIATRY

SNP rs4971059 predisposes to breast carcinogenesis and chemoresistance via TRIM46‐mediated HDAC1 degradation

(2021) Zihan Zhang et al.   EMBO JOURNAL

Effect of Exogenous pH on Cell Growth of Breast Cancer Cells

(2021) Sungmun Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy

(2021) Meiou Dai et al.   Nature Communications

CRISPR-Cas13 System as a Promising and Versatile Tool for Cancer Diagnosis, Therapy, and Research

(2021) Fahreddin Palaz et al.   ACS Synthetic Biology

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

(2021) Maarten H Geurts et al.   Life Science Alliance

Type III CRISPR-Cas Systems: Deciphering the Most Complex Prokaryotic Immune System

(2021) Matvey V. Kolesnik et al.   BIOCHEMISTRY-MOSCOW

Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy

(2021) Toshiaki Yoshikawa et al.   BLOOD

Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer

(2021) Deli Hong et al.   CANCER RESEARCH

Two distinct mechanisms underlie estrogen-receptor-negative breast cancer susceptibility at the 2p23.2 locus

(2021) Gustavo Mendoza-Fandiño et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations

(2021) Yin Liu et al.   Molecular Cancer

Associations Between CAMKK1 Polymorphism rs7214723 and the Prognosis of Patients With Lung Cancer

(2021) Haorui Zhang et al.   Frontiers in Oncology

Preclinical efficacy and safety evaluation of interleukin-6-knockdown CAR-T cells targeting at CD19

(2021) Hairuo Wen et al.   Annals of Translational Medicine

Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells

(2021) Rui Tian et al.   Molecular Therapy-Oncolytics

Cellular Retinoic-Acid Binding Protein 2 in solid tumor

(2020) Xiaoyang Jiao et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

In situ CRISPR‐Cas9 base editing for the development of genetically engineered mouse models of breast cancer

(2020) Stefano Annunziato et al.   EMBO JOURNAL

Gene targeting of HPV18 E6 and E7 synchronously by non-viral transfection of CRISPR/Cas9 system in cervical cancer

(2020) Kaijian Ling et al.   HUMAN GENE THERAPY

Human Papillomavirus Oncogene Manipulation Using Clustered Regularly Interspersed Short Palindromic Repeats/Cas9 Delivered by pH-Sensitive Cationic Liposomes

(2020) Shuai Zhen et al.   HUMAN GENE THERAPY

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power

(2020) Dangquan Zhang et al.   TRENDS IN GENETICS

Efficient generation of mouse models with the prime editing system

(2020) Yao Liu et al.   Cell Discovery

In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs’ cleavage by CRISPR/Cas13a system

(2020) Yili Chen et al.   ANTIVIRAL RESEARCH

Genome-scale CRISPR activation screening identifies a role of LRP8 in Sorafenib resistance in Hepatocellular carcinoma

(2020) Jun Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

(2020) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes

(2020) Liqing Kang et al.   Experimental Hematology & Oncology

CRISPR/Cas gene therapy

(2020) Baohong Zhang   JOURNAL OF CELLULAR PHYSIOLOGY

Prime editing for functional repair in patient-derived disease models

(2020) Imre F. Schene et al.   Nature Communications

CRISPR/Cas: a powerful tool for gene function study and crop improvement

(2020) Dangquan Zhang et al.   Journal of Advanced Research

A web tool for the design of prime-editing guide RNAs

(2020) Ryan D. Chow et al.   Nature Biomedical Engineering

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination

(2019) Noboru Ideno et al.   LABORATORY INVESTIGATION

Disruption of CTLA-4 expression on peripheral blood CD8 + T cell enhances anti-tumor efficacy in bladder cancer

(2019) Wei Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity

(2019) Yuanyue Shan et al.   ANALYTICAL CHEMISTRY

An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer

(2019) Steven Feins et al.   AMERICAN JOURNAL OF HEMATOLOGY

CRISPR Cpf1 proteins: structure, function and implications for genome editing

(2019) Fatemeh Safari et al.   Cell and Bioscience

The SNP of rs6854845 suppresses transcription via the DNA looping structure alteration of super-enhancer in colon cells

(2019) Zhuangzhi Cong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

(2019) Johanna F Dekkers et al.   JNCI-Journal of the National Cancer Institute

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

DAPK1 loss triggers tumor invasion in colorectal tumor cells

(2019) Sara Steinmann et al.   Cell Death & Disease

CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection

(2019) Qian Chen et al.   ANALYTICAL CHEMISTRY

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

(2019) Sheng Rong Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of a DAPK1 knockout first (conditional ready) human embryonic stem cell line (ZSSYe001-A) by CRISPR-Cas9 technology

(2019) Cancan Xu et al.   Stem Cell Research

CRISPR–Cas13 Precision Transcriptome Engineering in Cancer

(2018) Javier T. Granados-Riveron et al.   CANCER RESEARCH

Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma

(2018) Weijian Sun et al.   LABORATORY INVESTIGATION

Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein

(2018) Winston X. Yan et al.   MOLECULAR CELL

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

CRISPR-Based Gene Drives for Pest Control

(2018) Gus R. McFarlane et al.   TRENDS IN BIOTECHNOLOGY

Neurotoxicity after CTL019 in a Pediatric and Young Adult Cohort

(2018) Jacqueline S. Gofshteyn et al.   ANNALS OF NEUROLOGY

Systems analysis of intracellular pH vulnerabilities for cancer therapy

(2018) Erez Persi et al.   Nature Communications

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

(2018) Rosalie M. Sterner et al.   BLOOD

CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions

(2018) Wanghong Hu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma

(2018) Xiaoteng Cui et al.   RNA Biology

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

(2017) Daniel T. MacLeod et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

RNA targeting with CRISPR–Cas13

(2017) Omar O. Abudayyeh et al.   NATURE

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

The expression of APE1 in triple-negative breast cancer and its effect on drug sensitivity of olaparib

(2017) Tianran Chen et al.   TUMOR BIOLOGY

CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome

(2017) Ha Youn Shin et al.   Nature Communications

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

(2017) Levi J. Rupp et al.   Scientific Reports

CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice

(2017) Yongzhen Liu et al.   Scientific Reports

CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice

(2017) Yu Zhang et al.   Science Advances

Tudor staphylococcal nuclease: biochemistry and functions

(2016) Emilio Gutierrez-Beltran et al.   CELL DEATH AND DIFFERENTIATION

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

(2016) Jiangtao Ren et al.   CLINICAL CANCER RESEARCH

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

CRISPR-Cas: biology, mechanisms and relevance

(2016) Frank Hille et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients

(2016) Shu Su et al.   Scientific Reports

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

(2016) Morito Kurata et al.   Scientific Reports

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing

(2015) Shin-Heng Chiou et al.   GENES & DEVELOPMENT

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

ClinVar: public archive of interpretations of clinically relevant variants

(2015) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil-based chemotherapy in Bangladeshi breast cancer patients

(2015) Md. Siddiqul Islam et al.   TUMOR BIOLOGY

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

(2014) Hiroshi Nishimasu et al.   CELL

Vector Integration and Tumorigenesis

(2014) Christof von Kalle et al.   HUMAN GENE THERAPY

CRABP-II is a highly sensitive and specific diagnostic molecular marker for pancreatic ductal adenocarcinoma in distinguishing from benign pancreatic conditions

(2014) Wenbin Xiao et al.   HUMAN PATHOLOGY

Dissecting mammalian immunity through mutation

(2014) Owen M Siggs   IMMUNOLOGY AND CELL BIOLOGY

Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial

(2014) Caroline Robert et al.   LANCET

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

(2014) Carolin Anders et al.   NATURE

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

(2014) Francisco J. Sánchez-Rivera et al.   NATURE

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

(2014) Danilo Maddalo et al.   NATURE

CRISPR-mediated direct mutation of cancer genes in the mouse liver

(2014) Wen Xue et al.   NATURE

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

(2014) Dirk Heckl et al.   NATURE BIOTECHNOLOGY

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

CRISPR-Cas systems and RNA-guided interference

(2013) Rodolphe Barrangou   Wiley Interdisciplinary Reviews-RNA

Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population

(2012) Jing Dong et al.   NATURE GENETICS

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

(2012) G. Gasiunas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Identification of Staphylococcal Nuclease Domain-containing 1 (SND1) as a Metadherin-interacting Protein with Metastasis-promoting Functions

(2011) Mario Andres Blanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

5-fluorouracil drug alters the microrna expression profiles in MCF-7 breast cancer cells

(2010) Maitri Y. Shah et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE