PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis

Copper metabolism in cell death and autophagy

(2023) Qian Xue et al.   Autophagy

Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice

(2023) Yi Wang et al.   ENVIRONMENTAL POLLUTION

Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice

(2023) Qing Yang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Zinc oxide nanoparticles have biphasic roles on Mycobacterium-induced inflammation by activating autophagy and ferroptosis mechanisms in infected macrophages

(2023) SiJia Geng et al.   MICROBIAL PATHOGENESIS

Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function

(2022) Hui Shan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury

(2022) Ruyuan He et al.   Cell Death Discovery

Lnc-IL7R alleviates PM2.5-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease

(2022) Kang-Yun Lee et al.   CELL BIOLOGY AND TOXICOLOGY

Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis

(2022) Ying Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sipeimine ameliorates PM2.5-induced lung injury by inhibiting ferroptosis via the PI3K/Akt/Nrf2 pathway: A network pharmacology approach

(2022) Yilan Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury

(2022) Hui Chen et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

PM2.5 Exposure Induces Lung Injury and Fibrosis by Regulating Ferroptosis via TGF-β Signaling

(2022) Li Guo et al.   DISEASE MARKERS

PM2.5 inhibits system Xc- activity to induce ferroptosis by activating the AMPK-Beclin1 pathway in acute lung injury

(2022) Kun Yan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Long-term exposure to PM2.5 aggravates pulmonary fibrosis and acute lung injury by disrupting Nrf2-mediated antioxidant function

(2022) Chen Zhao et al.   ENVIRONMENTAL POLLUTION

Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice

(2022) Xiaoming Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1α-Dependent Mechanisms

(2022) Chunxia Liu et al.   Oxidative Medicine and Cellular Longevity

Senescence of alveolar epithelial cells impacts initiation and chronic phases of murine fibrosing interstitial lung disease

(2022) Zento Yamada et al.   Frontiers in Immunology

A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2

(2022) Li Ning et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selenomethionine mitigate PM2.5-induced cellular senescence in the lung via attenuating inflammatory response mediated by cGAS/STING/NF-κB pathway

(2022) Xiaofei Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Regulatory Role of Ubiquitin Specific Protease-13 (USP13) in Misfolded Protein Clearance in Neurodegenerative Diseases

(2021) Xiaoguang Liu et al.   NEUROSCIENCE

SIRT3 consolidates heterochromatin and counteracts senescence

(2021) Zhiqing Diao et al.   NUCLEIC ACIDS RESEARCH

Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM 2 .5 in mice

(2021) Mengmeng Xu et al.   ENVIRONMENTAL TOXICOLOGY

PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice

(2021) Rui Xiong et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The impact of organic extracts of seasonal PM2.5 on primary human lung epithelial cells and their chemical characterization

(2021) Jieun Park et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Sirtuin 3 Ameliorates Lung Senescence and Improves Type II Alveolar Epithelial Cell Function by Enhancing the FoxO3a-Dependent Antioxidant Defense Mechanism

(2021) Jian-Xin Chen et al.   STEM CELLS AND DEVELOPMENT

Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3

(2021) Qi Zhou et al.   Bioengineered

PM2.5 exposure perturbs lung microbiome and its metabolic profile in mice

(2020) Jingli Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

miR‐155‐5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

(2020) Yimei Hong et al.   AGING CELL

The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis

(2020) Yuzhe He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ambient air pollution and its influence on human health and welfare: an overview

(2020) Alsaid Ahmed Almetwally et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

(2020) Changfu Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis

(2020) Lawei Yang et al.   Cell Death & Disease

SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway

(2020) Tongshuai Chen et al.   LIFE SCIENCES

Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress

(2020) Ying Jin et al.   Journal of Molecular Cell Biology

Inhibition of the P53 / P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell‐Derived Exosomes on the Senescence of Nucleus Pulposus Cells

(2020) Chang‐chun Chen et al.   Orthopaedic Surgery

SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions

(2019) Tae Sung Kim et al.   Autophagy

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

(2019) Peter J Barnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

(2019) Masahiro Yoshida et al.   Nature Communications

Association Between Long-term Exposure to Ambient Air Pollution and Change in Quantitatively Assessed Emphysema and Lung Function

(2019) Meng Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Air pollution-derived PM2.5 impairs mitochondrial function in healthy and chronic obstructive pulmonary diseased human bronchial epithelial cells

(2018) B. Leclercq et al.   ENVIRONMENTAL POLLUTION

Selenium, Selenoproteins, and Immunity

(2018) Joseph Avery et al.   Nutrients

PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

(2017) Miao He et al.   JOURNAL OF APPLIED TOXICOLOGY

Urban particulate matter in Beijing, China, enhances allergen-induced murine lung eosinophilia

(2010) Miao He et al.   INHALATION TOXICOLOGY

Endurance Exercise as a Countermeasure for Aging

(2008) I. R. Lanza et al.   DIABETES