Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies

Anti-fibrillization effects of sulfonamide derivatives on α-synuclein and hyperphosphorylated tau isoform 1N4R

(2022) Jessica S. Fortin et al.   JOURNAL OF MOLECULAR STRUCTURE

A Single-Chain Variable Fragment Antibody Inhibits Aggregation of Phosphorylated Tau and Ameliorates Tau Toxicity in vitro and in vivo

(2021) Sen Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice

(2021) Rinie Bajracharya et al.   Acta Neuropathologica Communications

Tau forms oligomeric complexes on microtubules that are distinct from tau aggregates

(2021) Melina Theoni Gyparaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer disease

(2021) David S. Knopman et al.   Nature Reviews Disease Primers

A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies

(2021) Bruno P. Imbimbo et al.   Alzheimers & Dementia

A current view on Tau protein phosphorylation in Alzheimer's disease

(2021) Susanne Wegmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models

(2021) Hoi-Khoanh Giong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation

(2021) Manivannan Subramanian et al.   Nature Communications

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2021) Tamta Arakhamia et al.   CELL

Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation

(2021) Diana M. Acosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission of tauopathy strains is independent of their isoform composition

(2020) Zhuohao He et al.   Nature Communications

Role of tau protein in Alzheimer's disease: The prime pathological player

(2020) Shibi Muralidar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis

(2020) Jean-Pierre Roussarie et al.   NEURON

Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions

(2020) Mengyu Liu et al.   Scientific Reports

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

New Insights Into Drug Discovery Targeting Tau Protein

(2020) Yoshiyuki Soeda et al.   Frontiers in Molecular Neuroscience

Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease

(2019) Yoshiyuki Soeda et al.   JOURNAL OF ALZHEIMERS DISEASE

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau

(2019) Sneha Narasimhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

(2019) Filippa Lo Cascio et al.   Scientific Reports

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

(2019) Ebru Ercan-Herbst et al.   Acta Neuropathologica Communications

Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease

(2018) Chelsea T Tiernan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

First-in-Rat Study of Human Alzheimer’s Disease Tau Propagation

(2018) Tomas Smolek et al.   MOLECULAR NEUROBIOLOGY

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

Tau Transgenic Mice as Models for Cerebrospinal Fluid Tau Biomarkers

(2018) Donna M. Barten et al.   JOURNAL OF ALZHEIMERS DISEASE

Animal models of neurodegenerative diseases

(2018) Ted M. Dawson et al.   NATURE NEUROSCIENCE

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Pathological Changes of Tau Related to Alzheimer’s Disease

(2018) Dandan Chu et al.   ACS Chemical Neuroscience

Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

(2018) Alejandra D. Alonso et al.   Frontiers in Cellular Neuroscience

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy

(2017) Megan A. Sealey et al.   NEUROBIOLOGY OF DISEASE

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Tau oligomers in cerebrospinal fluid in Alzheimer's disease

(2017) Urmi Sengupta et al.   Annals of Clinical and Translational Neurology

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic Acid)

(2015) Nadine D. Younan et al.   BIOCHEMISTRY

Clinicopathologic and11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

(2015) Melissa E. Murray et al.   BRAIN

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

(2015) S. Wegmann et al.   EMBO JOURNAL

Further understanding of tau phosphorylation: implications for therapy

(2015) Miguel Medina et al.   Expert Review of Neurotherapeutics

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Invited review: Animal models of tauopathies and their implications for research/translation into the clinic

(2015) Simon Dujardin et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers

(2015) Catherine M. Cowan et al.   Scientific Reports

Further understanding of tau phosphorylation: implications for therapy

(2015) Miguel Medina et al.   Expert Review of Neurotherapeutics

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia

(2014) Casey Cook et al.   NEUROBIOLOGY OF AGING

Cell-based Models To Investigate Tau Aggregation

(2014) Sungsu Lim et al.   Computational and Structural Biotechnology Journal

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Characteristics of Tau Oligomers

(2013) Yan Ren et al.   Frontiers in Neurology

Tau oligomers and tau toxicity in neurodegenerative disease

(2012) Sarah M. Ward et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Neuropathology after active Aβ42 immunotherapy: implications for Alzheimer’s disease pathogenesis

(2010) Delphine Boche et al.   ACTA NEUROPATHOLOGICA

Characterization of tau fibrillization in vitro

(2010) Shaohua Xu et al.   Alzheimers & Dementia

Amyloid structure and assembly: Insights from scanning transmission electron microscopy

(2010) Claire Goldsbury et al.   JOURNAL OF STRUCTURAL BIOLOGY

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathies

(2009) Jozef Hanes et al.   JOURNAL OF NEUROCHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

The Natively Unfolded Character of Tau and Its Aggregation to Alzheimer-like Paired Helical Filaments†

(2008) Sadasivam Jeganathan et al.   BIOCHEMISTRY

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Tau isoform regulation is region- and cell-specific in mouse brain

(2008) Pamela McMillan et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

(2007) Roland Brandt et al.   NEUROBIOLOGY OF AGING