Anti-fibrillization effects of sulfonamide derivatives on α-synuclein and hyperphosphorylated tau isoform 1N4R

In vitro characterization of urea derivatives to inhibit alpha-synuclein early-stage aggregation

(2021) Soham Maity et al.   JOURNAL OF MOLECULAR STRUCTURE

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

(2020) Elizabeth Terry-Kantor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulating Disease-Relevant Tau Oligomeric Strains by Small Molecules

(2020) Filippa Lo Cascio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death

(2020) Mengyu Liu et al.   MOLECULAR NEUROBIOLOGY

Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions

(2020) Mengyu Liu et al.   Scientific Reports

Pathological Tau From Alzheimer’s Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo

(2019) Jin Miao et al.   Frontiers in Aging Neuroscience

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

(2019) Clément Despres et al.   ACS Chemical Biology

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

(2019) Thibaut Imberdis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-in-Rat Study of Human Alzheimer’s Disease Tau Propagation

(2018) Tomas Smolek et al.   MOLECULAR NEUROBIOLOGY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Effective suppression of the modified PHF6 peptide/1N4R Tau amyloid aggregation by intact curcumin, not its degradation products: Another evidence for the pigment as preventive/therapeutic “functional food”

(2018) Nooshin Bijari et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Cationic red emitting fluorophore: A light up NIR fluorescent probe for G4-DNA

(2018) Beena Kumari et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

(2016) Travis T. Wager et al.   ACS Chemical Neuroscience

Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity

(2016) Jessica S. Fortin et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

No “breakthrough” in Alzheimer’s disease

(2016) Jacqui Wise   BMJ-British Medical Journal

No “breakthrough” in Alzheimer’s disease

(2016) Jacqui Wise   BMJ-British Medical Journal

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

(2015) Yoshiyuki Soeda et al.   Nature Communications

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

(2014) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Interaction Module–assisted Function X (PIMAX) Approach to Producing Challenging Proteins Including Hyperphosphorylated Tau and Active CDK5/p25 Kinase Complex

(2014) Dexin Sui et al.   MOLECULAR & CELLULAR PROTEOMICS

Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data

(2013) Anna Artese et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

(2013) Alex Crowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

(2009) Bruno Bulic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE