Newer modalities in the management of Alzheimer's dementia along with the role of aducanumab and lecanemab in the treatment of its refractory cases

Long-Term Health Outcomes of Lecanemab in Patients with Early Alzheimer’s Disease Using Simulation Modeling

(2022) Amir Abbas Tahami Monfared et al.   Neurology and Therapy

Lecanemab for Alzheimer's disease: tempering hype and hope

(2022) The Lancet   LANCET

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering

(2021) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Aducanumab: Appropriate use recommendations

(2021) Jeffrey Cummings et al.   Alzheimers & Dementia

Aducanumab: First Approval

(2021) Sohita Dhillon   DRUGS

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease

(2018) Magdalena Martinez-Losa et al.   NEURON

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

(2018) Joseph W. Arndt et al.   Scientific Reports

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates

(2018) D. M. Vargas et al.   Alzheimers Research & Therapy

Stem cell therapy in Alzheimer’s disease: possible benefits and limiting drawbacks

(2018) Masoume Alipour et al.   MOLECULAR BIOLOGY REPORTS

The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation

(2017) Kirsteen N. Browning et al.   GASTROENTEROLOGY

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

Solanezumab: too late in mild Alzheimer's disease?

(2017) The Lancet Neurology   LANCET NEUROLOGY

Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2017) Jeff Sevigny et al.   NATURE

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Tau-based therapies in neurodegeneration: opportunities and challenges

(2017) Chuanzhou Li et al.   NATURE REVIEWS DRUG DISCOVERY

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Alzheimer’s disease: as it was in the beginning

(2017) Stanislav Kozlov et al.   REVIEWS IN THE NEUROSCIENCES

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

(2016) Carlo Sala Frigerio et al.   Annual Review of Neuroscience

Molecular and cellular pathophysiology of preclinical Alzheimer’s disease

(2016) Elliott J. Mufson et al.   BEHAVIOURAL BRAIN RESEARCH

Defining the earliest pathological changes of Alzheimer's disease

(2016) James C. Vickers et al.   Current Alzheimer Research

Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

(2016) Leide dos Santos Picanç et al.   CURRENT MEDICINAL CHEMISTRY

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model

(2016) Sung Hoon Baik et al.   GLIA

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

(2016) Dheeraj S. Roy et al.   NATURE

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Rhythms of the hippocampal network

(2016) Laura Lee Colgin   NATURE REVIEWS NEUROSCIENCE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples

(2016) Anna K. Gillespie et al.   NEURON

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS  -amyloid in animal models and in Alzheimers disease patients

(2016) M. E. Kennedy et al.   Science Translational Medicine

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

(2016) Mark Ultsch et al.   Scientific Reports

Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models

(2015) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease

(2015) Tejas Sankar et al.   Brain Stimulation

Effects of endocytosis on receptor-mediated signaling

(2015) Roshanak Irannejad et al.   CURRENT OPINION IN CELL BIOLOGY

Solanezumab—prospects for meaningful interventions in AD?

(2015) Sam Gandy et al.   Nature Reviews Neurology

GDF-15 Secreted from Human Umbilical Cord Blood Mesenchymal Stem Cells Delivered Through the Cerebrospinal Fluid Promotes Hippocampal Neurogenesis and Synaptic Activity in an Alzheimer's Disease Model

(2015) Dong Hyun Kim et al.   STEM CELLS AND DEVELOPMENT

Bystander Effect Fuels Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells to Quickly Attenuate Early Stage Neurological Deficits After Stroke

(2015) Auston Eckert et al.   Stem Cells Translational Medicine

Therapeutic Perspectives of Drugs Targeting Toll-Like Receptors Based on Immune Physiopathology Theory of Alzheimer’s Disease

(2014) Andrew Schneider et al.   CNS & Neurological Disorders-Drug Targets

Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

(2014) William M Pardridge   Expert Opinion on Drug Delivery

Targeting microglia for the treatment of Alzheimer’s disease

(2014) Patrick L McGeer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Human-induced pluripotent stem cells: potential for neurodegenerative diseases

(2014) C. A. Ross et al.   HUMAN MOLECULAR GENETICS

Effects of Silica and Titanium Oxide Particles on a Human Neural Stem Cell Line: Morphology, Mitochondrial Activity, and Gene Expression of Differentiation Markers

(2014) Kouki Fujioka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice

(2014) J. Knoferle et al.   JOURNAL OF NEUROSCIENCE

Inhibitory Interneuron Progenitor Transplantation Restores Normal Learning and Memory in ApoE4 Knock-In Mice without or with A  Accumulation

(2014) L. M. Tong et al.   JOURNAL OF NEUROSCIENCE

Combined Treatment with a BACE Inhibitor and Anti-A  Antibody Gantenerumab Enhances Amyloid Reduction in APPLondon Mice

(2014) H. Jacobsen et al.   JOURNAL OF NEUROSCIENCE

Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

(2014) J Kuhn et al.   MOLECULAR PSYCHIATRY

Slow and Fast Gamma Rhythms Coordinate Different Spatial Coding Modes in Hippocampal Place Cells

(2014) Kevin Wood Bieri et al.   NEURON

Targeting the Prodromal Stage of Alzheimer’s Disease: Bioenergetic and Mitochondrial Opportunities

(2014) Charles C. Caldwell et al.   Neurotherapeutics

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2

(2014) Koutaro Takamatsu et al.   Stem Cell Research

Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer’s disease

(2014) Karina O. Garcia et al.   Frontiers in Aging Neuroscience

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Safety and Pharmacology of Ponezumab (PF-04360365) After a Single 10-Minute Intravenous Infusion in Subjects With Mild to Moderate Alzheimer Disease

(2013) Aaron H. Burstein et al.   CLINICAL NEUROPHARMACOLOGY

Safety and Pharmacology of a Single Intravenous Dose of Ponezumab in Subjects With Mild-to-Moderate Alzheimer Disease

(2013) Jaren W. Landen et al.   CLINICAL NEUROPHARMACOLOGY

Long-term immunomodulatory effect of amniotic stem cells in an Alzheimer's disease model

(2013) Kyung-Sul Kim et al.   NEUROBIOLOGY OF AGING

Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis

(2013) M. Schrag et al.   NEUROBIOLOGY OF DISEASE

BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease

(2013) R. M. Burke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Adsorptive-Mediated Brain Delivery Systems

(2012) Wei Lu   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Molecular Pathology of Alzheimer's Disease

(2012) Charles R. Harrington   NEUROIMAGING CLINICS OF NORTH AMERICA

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Preclinical Assessment of Neural Stem Cells as Delivery Vehicles for Anti-Amyloid Therapeutics

(2012) eMalick G. Njie et al.   PLoS One

The Preventive and Therapeutic Effects of Intravenous Human Adipose-Derived Stem Cells in Alzheimer’s Disease Mice

(2012) Saeromi Kim et al.   PLoS One

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease

(2011) Sherry L. La Porte et al.   JOURNAL OF MOLECULAR BIOLOGY

Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults

(2011) D. Putcha et al.   JOURNAL OF NEUROSCIENCE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

A potential role for the PD1/PD-L1 pathway in the neuroinflammation of Alzheimer's disease

(2011) Marina Saresella et al.   NEUROBIOLOGY OF AGING

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease

(2010) Adrian W. Laxton et al.   ANNALS OF NEUROLOGY

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

(2010) David W. Klaver et al.   BIOLOGICAL CHEMISTRY

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation

(2010) Hyun Ju Lee et al.   NEUROBIOLOGY OF AGING

A PHASE 2 MULTIPLE ASCENDING DOSE TRIAL OF BAPINEUZUMAB IN MILD TO MODERATE ALZHEIMER DISEASE

(2010) D. T. Laskowitz et al.   NEUROLOGY

Frequency of gamma oscillations routes flow of information in the hippocampus

(2009) Laura Lee Colgin et al.   NATURE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Identification of Novel APP/Aβ Isoforms in Human Cerebrospinal Fluid

(2009) Erik Portelius et al.   Neurodegenerative Diseases

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays

(2008) Paolo Bianco et al.   Cell Stem Cell

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON