Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer’s disease

(2010) David W. Klaver et al.   JOURNAL OF NEUROCHEMISTRY

Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons

(2009) Hyun Jin Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1–calcium interaction

(2009) Michael Hayley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer’s disease animal model

(2009) H. J. Cho et al.   FASEB JOURNAL

Cell biology, regulation and inhibition of β-secretase (BACE-1)

(2009) Clare E. Hunt et al.   FEBS Journal

Reduced Amyloid Deposition in Mice Overexpressing RTN3 Is Adversely Affected by Preformed Dystrophic Neurites

(2009) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk

(2008) Ute Dreses-Werringloer et al.   CELL

Understanding BACE1: essential protease for amyloid-β production in Alzheimer’s disease

(2008) J. H. Stockley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

Alzheimer Disease Aβ Production in the Absence ofS-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

(2008) Kulandaivelu S. Vetrivel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42

(2008) Virginie Buggia-Prevot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

(2008) Romano Silvestri   MEDICINAL RESEARCH REVIEWS

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

Neuroinflammation in Plaque and Vascular β-Amyloid Disorders: Clinical and Therapeutic Implications

(2008) Piet Eikelenboom et al.   Neurodegenerative Diseases

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

(2008) Bastian G. Brinkmann et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE