The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors

Structural perspective of class B1 GPCR signaling

(2022) Zhaotong Cong et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural basis of the activation of metabotropic glutamate receptor 3

(2022) Wei Fang et al.   CELL RESEARCH

Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1

(2022) Xin Yang et al.   Nature Chemical Biology

The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands

(2022) Jingjing Wang et al.   Nature Communications

Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex

(2022) Geng Chen et al.   Nature Communications

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

(2022) Kaihua Zhang et al.   Nature Communications

Ligand recognition and biased agonism of the D1 dopamine receptor

(2022) Xiao Teng et al.   Nature Communications

Allosteric modulation of GPCRs: From structural insights to in silico drug discovery

(2022) Margherita Persechino et al.   PHARMACOLOGY & THERAPEUTICS

GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources

(2022) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

Structural insights into the human D1 and D2 dopamine receptor signaling complexes

(2021) Youwen Zhuang et al.   CELL

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

(2021) Youwen Zhuang et al.   CELL RESEARCH

Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan

(2021) Shenglong Ling et al.   CELL RESEARCH

Structural basis of GABAB receptor–Gi protein coupling

(2021) Cangsong Shen et al.   NATURE

Predictable cholesterol binding sites in GPCRs lack consensus motifs

(2021) Geoffrey J. Taghon et al.   STRUCTURE

Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery

(2021) Lauren M. Slosky et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Asymmetric activation of the calcium-sensing receptor homodimer

(2021) Yang Gao et al.   NATURE

G-protein activation by a metabotropic glutamate receptor

(2021) Alpay B. Seven et al.   NATURE

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4

(2021) Shuling Lin et al.   NATURE

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

(2021) Christopher J. Draper-Joyce et al.   NATURE

Routine sub-2.5 Å cryo-EM structure determination of GPCRs

(2021) Radostin Danev et al.   Nature Communications

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

(2021) Zhaotong Cong et al.   Nature Communications

Structural insights into the activation of human calcium-sensing receptor

(2021) Xiaochen Chen et al.   eLife

Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor

(2021) Tianlei Wen et al.   Science Advances

Structures of full-length glycoprotein hormone receptor signalling complexes

(2021) Jia Duan et al.   NATURE

Nanobody-enabled monitoring of kappa opioid receptor states

(2020) Tao Che et al.   Nature Communications

Cryo-EM structures of inactive and active GABAB receptor

(2020) Chunyou Mao et al.   CELL RESEARCH

Structural basis of the activation of a metabotropic GABA receptor

(2020) Hamidreza Shaye et al.   NATURE

Structure of human GABAB receptor in an inactive state

(2020) Jinseo Park et al.   NATURE

Structures of metabotropic GABAB receptor

(2020) Makaía M. Papasergi-Scott et al.   NATURE

Structural basis of GPBAR activation and bile acid recognition

(2020) Fan Yang et al.   NATURE

Structural insights into probe-dependent positive allosterism of the GLP-1 receptor

(2020) Ana B. Bueno et al.   Nature Chemical Biology

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

(2020) Naotaka Tsutsumi et al.   eLife

Structural Basis for Activation of the Heterodimeric GABAB Receptor

(2020) Yoojoong Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function

(2020) Amr Ellaithy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes

(2019) Shoji Maeda et al.   SCIENCE

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

(2019) Zhenhua Shao et al.   Nature Chemical Biology

Recent advances in the determination of G protein-coupled receptor structures

(2018) David M Thal et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Illuminating GPCR Signaling by Cryo-EM

(2018) Haaris Ahsan Safdari et al.   TRENDS IN CELL BIOLOGY

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

(2018) Christopher J. Draper-Joyce et al.   NATURE

Structural insights into G-protein-coupled receptor allostery

(2018) David M. Thal et al.   NATURE

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

(2017) Jun Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs

(2017) Miles Congreve et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

(2017) Jun Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Allosteric Modulators of G Protein-coupled Receptors

(2015) Patrick R. Gentry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two disparate ligand-binding sites in the human P2Y1 receptor

(2015) Dandan Zhang et al.   NATURE

Methodological advances: the unsung heroes of the GPCR structural revolution

(2015) Eshan Ghosh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES