Predictable cholesterol binding sites in GPCRs lack consensus motifs

CRISPR-addressable yeast strains with applications in human G protein–coupled receptor profiling and synthetic biology

(2020) Jacob B. Rowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery

(2020) N. J. Kapolka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into emergent signaling modes of G protein–coupled receptors

(2020) Ieva Sutkeviciute et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HCAR3: an underexplored metabolite sensor

(2020) Nicholas J. Kapolka et al.   NATURE REVIEWS DRUG DISCOVERY

Diverse GPCRs exhibit conserved water networks for stabilization and activation

(2019) A. J. Venkatakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-Electron Microscopy: Moving Beyond X-Ray Crystal Structures for Drug Receptors and Drug Development

(2019) Javier García-Nafría et al.   Annual Review of Pharmacology and Toxicology

Outline of the biosynthesis and regulation of ergosterol in yeast

(2019) Jun-Feng Liu et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Lipid-Dependent Regulation of Ion Channels and G Protein–Coupled Receptors: Insights from Structures and Simulations

(2019) Anna L. Duncan et al.   Annual Review of Pharmacology and Toxicology

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

(2019) Alan V. Smrcka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Beyond the Ligand: Extracellular and Transcellular G Protein–Coupled Receptor Complexes in Physiology and Pharmacology

(2019) Henry A. Dunn et al.   PHARMACOLOGICAL REVIEWS

Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots

(2019) Silvia Lovera et al.   Scientific Reports

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Validation of ligands in macromolecular structures determined by X-ray crystallography

(2018) Oliver S. Smart et al.   Acta Crystallographica Section D-Structural Biology

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Regulation of Ras Paralog Thermostability by Networks of Buried Ionizable Groups

(2016) Daniel G. Isom et al.   BIOCHEMISTRY

Molecular mechanisms of protein-cholesterol interactions in plasma membranes: Functional distinction between topological (tilted) and consensus (CARC/CRAC) domains

(2016) Jacques Fantini et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Interaction of G protein coupled receptors and cholesterol

(2016) Gerald Gimpl   CHEMISTRY AND PHYSICS OF LIPIDS

Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation

(2015) Daniel G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A comprehensive review of the lipid cubic phase orin mesomethod for crystallizing membrane and soluble proteins and complexes

(2015) Martin Caffrey   Acta Crystallographica Section F-Structural Biology Communications

How well does cholesteryl hemisuccinate mimic cholesterol in saturated phospholipid bilayers?

(2014) Waldemar Kulig et al.   JOURNAL OF MOLECULAR MODELING

Protons as Second Messenger Regulators of G Protein Signaling

(2013) Daniel G. Isom et al.   MOLECULAR CELL

How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

(2013) Jacques Fantini et al.   Frontiers in Physiology

Cholesterol-induced conformational changes in the oxytocin receptor

(2011) Sabine Muth et al.   BIOCHEMICAL JOURNAL

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

(2011) Ross M. Potter et al.   JOURNAL OF LIPID RESEARCH

Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor

(2011) Sergio Oddi et al.   JOURNAL OF NEUROCHEMISTRY

Cholesterol Regulates  -Opioid Receptor-Induced  -Arrestin 2 Translocation to Membrane Lipid Rafts

(2011) Y. Qiu et al.   MOLECULAR PHARMACOLOGY

Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors

(2010) Md. Jafurulla et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Visualizing Water Molecules in Transmembrane Proteins Using Radiolytic Labeling Methods

(2010) Tivadar Orban et al.   BIOCHEMISTRY

Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions

(2010) Grigore D. Pintilie et al.   JOURNAL OF STRUCTURAL BIOLOGY

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE