Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
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Title
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
Authors
Keywords
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Journal
NATURE
Volume 594, Issue 7864, Pages 583-588
Publisher
Springer Science and Business Media LLC
Online
2021-06-17
DOI
10.1038/s41586-021-03495-2
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- (2016) L. Lundström et al. NEUROPHARMACOLOGY
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- (2015) Andrew S. Dixon et al. ACS Chemical Biology
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- (2015) Xavier Rovira et al. FASEB JOURNAL
- Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
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- (2015) James A. Monn et al. JOURNAL OF MEDICINAL CHEMISTRY
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- Selectivity and Evolutionary Divergence of Metabotropic Glutamate Receptors for Endogenous Ligands and G Proteins Coupled to Phospholipase C or TRP Channels
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- PHENIX: a comprehensive Python-based system for macromolecular structure solution
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