PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects

(2022) Mary Beth Wire et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Topical S. aureus - Targeting Endolysin Significantly Improves Symptoms and QoL in Individuals With Atopic Dermatitis

(2022) Magali Moreau et al.   Journal of Drugs in Dermatology

Novel Phage Lysin Abp013 against Acinetobacter baumannii

(2022) Joash Jun Keat Chu et al.   Antibiotics-Basel

Isolation of Klebsiella pneumoniae Phage vB_KpnS_MK54 and Pathological Assessment of Endolysin in the Treatment of Pneumonia Mice Model

(2022) Biao Lu et al.   Frontiers in Microbiology

Direct Lytic Agents: Novel, Rapidly Acting Potential Antimicrobial Treatment Modalities for Systemic Use in the Era of Rising Antibiotic Resistance

(2022) Raymond Schuch et al.   Frontiers in Microbiology

Treatment Heterogeneity in Pseudomonas aeruginosa Pneumonia

(2022) Aisling R. Caffrey et al.   Antibiotics-Basel

State-of-the-art review of secondary pulmonary infections in patients with COVID-19 pneumonia

(2021) Woon H. Chong et al.   INFECTION

Decontamination of Escherichia coli O157:H7 on fresh Romaine lettuce using a novel bacteriophage lysin

(2021) Siyue Xu et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

A Novel Acinetobacter baumannii Bacteriophage Endolysin LysAB54 With High Antibacterial Activity Against Multiple Gram-Negative Microbes

(2021) Fazal Mehmood Khan et al.   Frontiers in Cellular and Infection Microbiology

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

(2021) Eun-Jeong Yoon et al.   Frontiers in Microbiology

Current and future perspectives in the treatment of multidrug-resistant Gram-negative infections

(2021) Matteo Bassetti et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovering the Potentials of Four Phage Endolysins to Combat Gram-Negative Infections

(2021) Daria V. Vasina et al.   Frontiers in Microbiology

TSPphg Lysin from the Extremophilic Thermus Bacteriophage TSP4 as a Potential Antimicrobial Agent against Both Gram-Negative and Gram-Positive Pathogenic Bacteria

(2020) Feng Wang et al.   Viruses-Basel

Klebsiella pneumoniae: an increasing threat to public health

(2020) Clement Yaw Effah et al.   Annals of Clinical Microbiology and Antimicrobials

Antimicrobial activity of LysSS, a novel phage endolysin, against Acinetobacter baumannii and Pseudomonas aeruginosa

(2020) Shukho Kim et al.   Journal of Global Antimicrobial Resistance

In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens

(2020) Lucia Blasco et al.   Scientific Reports

Lysin LysMK34 of Acinetobacter baumannii bacteriophage PMK34 has a turgor pressure-dependent intrinsic antibacterial activity and reverts colistin resistance.

(2020) Karim Abdelkader et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis

(2020) Vance G. Fowler et al.   JOURNAL OF CLINICAL INVESTIGATION

LysSAP26, a New Recombinant Phage Endolysin with a Broad Spectrum Antibacterial Activity

(2020) Shukho Kim et al.   Viruses-Basel

Broad Bactericidal Activity of the Myoviridae Bacteriophage Lysins LysAm24, LysECD7, and LysSi3 against Gram-Negative ESKAPE Pathogens

(2019) Nataliia Antonova et al.   Viruses-Basel

Geographical and temporal variation in the frequency and antimicrobial susceptibility of bacteria isolated from patients hospitalized with bacterial pneumonia: results from 20 years of the SENTRY Antimicrobial Surveillance Program (1997–2016)

(2019) Helio S Sader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Isolation of phage lysins that effectively kill Pseudomonas aeruginosa in mouse models of lung and skin infection

(2019) Assaf Raz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America

(2019) Joshua P. Metlay et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endolysins as emerging alternative therapeutic agent to counter drug resistant infections.

(2019) Vijay Singh Gondil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pseudomonas phragmitis sp. nov., isolated from petroleum polluted river sediment

(2019) Jing Li et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

In vitro characterization of PlyE146, a novel phage lysin that targets Gram-negative bacteria

(2018) Yu Larpin et al.   PLoS One

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

(2018) Zheng Pang et al.   BIOTECHNOLOGY ADVANCES

Phage Lysins for Fighting Bacterial Respiratory Infections: A New Generation of Antimicrobials

(2018) Roberto Vázquez et al.   Frontiers in Immunology

Prevalence of ESBL-producing Pseudomonas aeruginosa isolates in Warsaw, Poland, detected by various phenotypic and genotypic methods

(2017) Agnieszka E. Laudy et al.   PLoS One

The respiratory threat posed by multidrug resistant Gram-negative bacteria

(2017) Ana Rodrigo-Troyano et al.   RESPIROLOGY

Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae

(2017) Liangfei Xu et al.   Annals of Clinical Microbiology and Antimicrobials

Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms

(2017) Chang-Ro Lee et al.   Frontiers in Cellular and Infection Microbiology

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

(2017) Waqas Nasir Chaudhry et al.   PLoS One

Antimicrobial Activities of Ceftaroline and Comparator Agents against Bacterial Organisms Causing Bacteremia in Patients with Skin and Skin Structure Infections in U.S. Medical Centers, 2008 to 2014

(2016) Helio S. Sader et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Engineered Peptides of a Phage Lysin as Effective Antimicrobials against Multidrug-Resistant Acinetobacter baumannii

(2016) Mya Thandar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Klebsiella phages representing a novel clade of viruses with an unknown DNA modification and biotechnologically interesting enzymes

(2016) Barbara Maciejewska et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Community-Acquired Pneumonia Due to Multidrug- and Non–Multidrug-Resistant Pseudomonas aeruginosa

(2016) Catia Cillóniz et al.   CHEST

Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014

(2016) Lindsey M. Weiner et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections

(2016) Craig Winstanley et al.   TRENDS IN MICROBIOLOGY

Enhanced Antibacterial Activity of Acinetobacter baumannii Bacteriophage ØABP-01 Endolysin (LysABP-01) in Combination with Colistin

(2016) Rapee Thummeepak et al.   Frontiers in Microbiology

Novel Phage Lysin Capable of Killing the Multidrug-Resistant Gram-Negative Bacterium Acinetobacter baumannii in a Mouse Bacteremia Model

(2015) Rolf Lood et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Necrotizing fasciitis in patients with diabetes mellitus: clinical characteristics and risk factors for mortality

(2015) Nai-Chen Cheng et al.   BMC INFECTIOUS DISEASES

Bacteriophage phi11 lysin: Physicochemical characterization and comparison with phage phi80α lysin

(2015) Lyubov Y. Filatova et al.   ENZYME AND MICROBIAL TECHNOLOGY

Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii : Mechanisms and epidemiology

(2015) Anaïs Potron et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries

(2014) M. Castanheira et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

A Thermostable Salmonella Phage Endolysin, Lys68, with Broad Bactericidal Properties against Gram-Negative Pathogens in Presence of Weak Acids

(2014) Hugo Oliveira et al.   PLoS One

Engineered Endolysin-Based "Artilysins" To Combat Multidrug-Resistant Gram-Negative Pathogens

(2014) Y. Briers et al.   mBio

Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin

(2014) Jingmin Gu et al.   PLoS Pathogens

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of multidrug resistance on Pseudomonas aeruginosa ventilator-associated pneumonia outcome: predictors of early and crude mortality

(2013) C. Peña et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins

(2013) H. Oliveira et al.   JOURNAL OF VIROLOGY

Klebsiella pneumoniae liver abscesses

(2013) Theresa Seetoh et al.   LANCET INFECTIOUS DISEASES

Hypervirulent (hypermucoviscous)Klebsiella pneumoniae

(2013) Alyssa S. Shon et al.   Virulence

Characterization of five novel endolysins from Gram-negative infecting bacteriophages

(2012) Maarten Walmagh et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Using a bacteriocin structure to engineer a phage lysin that targetsYersinia pestis

(2012) Petra Lukacik et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bacteriophage endolysins as novel antimicrobials

(2012) Mathias Schmelcher et al.   Future Microbiology

Characterization of Modular Bacteriophage Endolysins from Myoviridae Phages OBP, 201φ2-1 and PVP-SE1

(2012) Maarten Walmagh et al.   PLoS One

Structural engineering of a phage lysin that targets Gram-negative pathogens

(2012) P. Lukacik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibacterial activity of Acinetobacter baumannii phage ϕAB2 endolysin (LysAB2) against both Gram-positive and Gram-negative bacteria

(2011) Meng-Jiun Lai et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Use of bacteriophage endolysin EL188 and outer membrane permeabilizers against Pseudomonas aeruginosa

(2011) Y. Briers et al.   JOURNAL OF APPLIED MICROBIOLOGY

Characterization of the staphylococcal bacteriophage lysin CHAPK

(2011) M. Fenton et al.   JOURNAL OF APPLIED MICROBIOLOGY

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus

(2010) A. Daniel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Chimeric Lysin Shows Superiority to Mupirocin for Skin Decolonization of Methicillin-Resistant and -SensitiveStaphylococcus aureusStrains

(2010) Mina Pastagia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pseudomonas aeruginosa: Host defence in lung diseases

(2010) Bryan J. WILLIAMS et al.   RESPIROLOGY