Antimicrobial Activities of Ceftaroline and Comparator Agents against Bacterial Organisms Causing Bacteremia in Patients with Skin and Skin Structure Infections in US Medical Centers, 2008 to 2014

We evaluated the antimicrobial susceptibility of 1,454 organisms consecutively collected from patients with bacteremia associated with skin and skin structure infections. The most common organisms obtained were Staphylococcus aureus (670 organisms [46.1%]), Escherichia coli (200 organisms [13.8%]), beta-hemolytic streptococci (beta HS) (138 organisms [9.5%]), and Klebsiella pneumoniae (109 organisms [7.5%]). The susceptibility rates for ceftaroline were 97.9% for S. aureus (95.9% among methicillin-resistant S. aureus [MRSA]), 100.0% for beta HS, 86.5% for E. coli, and 89.0% for K. pneumoniae. Ceftaroline and tigecycline provided the best overall coverage.