Decoding and Recoding of mRNA Sequences by the Ribosome

High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation

(2022) Miglė Kišonaitė et al.   Nature Communications

Evaluating ribosomal frameshifting in CCR5 mRNA decoding

(2022) Yousuf A. Khan et al.   NATURE

Mammalian proteome expansion by stop codon readthrough

(2022) Lekha E. Manjunath et al.   Wiley Interdisciplinary Reviews-RNA

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

(2022) Georgia M Cook et al.   eLife

Hyper-swivel head domain motions are required for complete mRNA-tRNA translocation and ribosome resetting

(2022) Wataru Nishima et al.   NUCLEIC ACIDS RESEARCH

Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon

(2022) Tarek Hilal et al.   SCIENCE

Altered tRNA dynamics during translocation on slippery mRNA as determinant of spontaneous ribosome frameshifting

(2022) Panagiotis Poulis et al.   Nature Communications

Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA

(2021) Howard Gamper et al.   Nature Communications

The expanding world of tRNA modifications and their disease relevance

(2021) Tsutomu Suzuki   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Most non-canonical proteins uniquely populate the proteome or immunopeptidome

(2021) Maria Virginia Ruiz Cuevas et al.   Cell Reports

Translation error clusters induced by aminoglycoside antibiotics

(2021) Ingo Wohlgemuth et al.   Nature Communications

Structural basis of early translocation events on the ribosome

(2021) Emily J. Rundlet et al.   NATURE

Twice exploration of tRNA +1 frameshifting in an elongation cycle of protein synthesis

(2021) Howard Gamper et al.   NUCLEIC ACIDS RESEARCH

Perturbation of ribosomal subunit dynamics by inhibitors of tRNA translocation

(2021) Riccardo Belardinelli et al.   RNA

Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation

(2021) Gabriel Demo et al.   Nature Communications

Oncogene-dependent sloppiness in mRNA translation

(2021) Julien Champagne et al.   MOLECULAR CELL

Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus

(2021) Chris H Hill et al.   NUCLEIC ACIDS RESEARCH

Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP

(2021) Christine E. Carbone et al.   Nature Communications

Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection

(2020) Justin C. Morse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading

(2020) Anna B. Loveland et al.   NATURE

Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer

(2020) Margalida Rosselló-Tortella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Domain IV of Elongation Factor EF-G Confer -1 Frameshifting

(2020) Dustin NIblett et al.   RNA

Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing

(2020) Eric D Hoffer et al.   eLife

Anti-tumour immunity induces aberrant peptide presentation in melanoma

(2020) Osnat Bartok et al.   NATURE

Reprogramming the genetic code

(2020) Daniel de la Torre et al.   NATURE REVIEWS GENETICS

Large-scale simulations of nucleoprotein complexes: ribosomes, nucleosomes, chromatin, chromosomes and CRISPR

(2019) Karissa Y Sanbonmatsu   CURRENT OPINION IN STRUCTURAL BIOLOGY

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance

(2019) Natalia Korniy et al.   NUCLEIC ACIDS RESEARCH

Spontaneous ribosomal translocation of mRNA and tRNAs into a chimeric hybrid state

(2019) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed –1 Ribosome Frameshifting on Viral and Bacterial mRNA s: mechanisms and biomedical implications [Au: OK ?]

(2019) Natalia Korniy et al.   FEBS LETTERS

The epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin?

(2019) Namit Ranjan et al.   FEBS LETTERS

Systematic Detection of Amino Acid Substitutions in Proteomes Reveals Mechanistic Basis of Ribosome Errors and Selection for Translation Fidelity

(2019) Ernest Mordret et al.   MOLECULAR CELL

Co-temporal Force and Fluorescence Measurements Reveal a Ribosomal Gear Shift Mechanism of Translation Regulation by Structured mRNAs

(2019) Varsha P. Desai et al.   MOLECULAR CELL

Translational recoding: canonical translation mechanisms reinterpreted

(2019) Marina V Rodnina et al.   NUCLEIC ACIDS RESEARCH

tRNA Dissociation from EF-Tu after GTP Hydrolysis: Primary Steps and Antibiotic Inhibition

(2019) Malte Warias et al.   BIOPHYSICAL JOURNAL

Thermodynamic control of −1 programmed ribosomal frameshifting

(2019) Lars V. Bock et al.   Nature Communications

Active role of elongation factor G in maintaining the mRNA reading frame during translation

(2019) Bee-Zen Peng et al.   Science Advances

How Messenger RNA and Nascent Chain Sequences Regulate Translation Elongation

(2018) Junhong Choi et al.   Annual Review of Biochemistry

Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation

(2018) Michael Y. Pavlov et al.   Annual Review of Biophysics

Eukaryotic translational termination efficiency is influenced by the 3′ nucleotides within the ribosomal mRNA channel

(2018) Andrew G Cridge et al.   NUCLEIC ACIDS RESEARCH

Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria

(2018) Alexey Rozov et al.   NUCLEIC ACIDS RESEARCH

Translation in Prokaryotes

(2018) Marina V. Rodnina   Cold Spring Harbor Perspectives in Biology

Translation Elongation and Recoding in Eukaryotes

(2018) Thomas E. Dever et al.   Cold Spring Harbor Perspectives in Biology

mRNA-Mediated Duplexes Play Dual Roles in the Regulation of Bidirectional Ribosomal Frameshifting

(2018) Wan-Ping Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Broad range of missense error frequencies in cellular proteins

(2018) Raffaella Garofalo et al.   NUCLEIC ACIDS RESEARCH

tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis

(2018) Julia Flis et al.   Cell Reports

Thio-Modification of tRNA at the Wobble Position as Regulator of the Kinetics of Decoding and Translocation on the Ribosome

(2017) Namit Ranjan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA

(2017) Neva Caliskan et al.   MOLECULAR CELL

Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene

(2017) Sezen Meydan et al.   MOLECULAR CELL

Ensemble cryo-EM elucidates the mechanism of translation fidelity

(2017) Anna B. Loveland et al.   NATURE

Ribosome dynamics during decoding

(2017) Marina V. Rodnina et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Review: Translational GTPases

(2016) Cristina Maracci et al.   BIOPOLYMERS

Evolutionary Dynamics of Abundant Stop Codon Readthrough

(2016) Irwin Jungreis et al.   MOLECULAR BIOLOGY AND EVOLUTION

The pathway to GTPase activation of elongation factor SelB on the ribosome

(2016) Niels Fischer et al.   NATURE

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Choreography of molecular movements during ribosome progression along mRNA

(2016) Riccardo Belardinelli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conserved rates and patterns of transcription errors across bacterial growth states and lifestyles

(2016) Charles C. Traverse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two proofreading steps amplify the accuracy of genetic code translation

(2016) Ka-Weng Ieong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Structural Insights into Translational Miscoding

(2016) Alexey Rozov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation

(2016) Kien Nguyen et al.   Nature Communications

How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome

(2016) Jeffrey K. Noel et al.   Nature Communications

Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code

(2016) Alexey Rozov et al.   Nature Communications

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Choreography of molecular movements during ribosome progression along mRNA

(2016) Riccardo Belardinelli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinetics of Spontaneous and EF-G-Accelerated Rotation of Ribosomal Subunits

(2016) Heena Sharma et al.   Cell Reports

Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression

(2015) Vivek M. Advani et al.   BIOESSAYS

Structural Snapshots of Actively Translating Human Ribosomes

(2015) Elmar Behrmann et al.   CELL

Ribosome Excursions during mRNA Translocation Mediate Broad Branching of Frameshift Pathways

(2015) Shannon Yan et al.   CELL

Fluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome

(2015) Sarah Adio et al.   Nature Communications

Structural insights into the translational infidelity mechanism

(2015) Alexey Rozov et al.   Nature Communications

Programmed –1 Frameshifting by Kinetic Partitioning during Impeded Translocation

(2014) Neva Caliskan et al.   CELL

The Ribosome Emerges from a Black Box

(2014) V. Ramakrishnan   CELL

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax

(2014) Sandeepa M. Eswarappa et al.   CELL

Dynamic pathways of −1 translational frameshifting

(2014) Jin Chen et al.   NATURE

Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway

(2014) Ashton Trey Belew et al.   NATURE

Evidence of efficient stop codon readthrough in four mammalian genes

(2014) Gary Loughran et al.   NUCLEIC ACIDS RESEARCH

A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation

(2014) H.-K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into translational recoding by frameshift suppressor tRNASufJ

(2014) Crystal E. Fagan et al.   RNA

How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocation

(2014) J. Zhou et al.   SCIENCE

Unusual −1 Ribosomal Frameshift Caused by Stable RNA G-Quadruplex in Open Reading Frame

(2013) Tamaki Endoh et al.   ANALYTICAL CHEMISTRY

G/U and Certain Wobble Position Mismatches as Possible Main Causes of Amino Acid Misincorporations

(2013) Zhongqi Zhang et al.   BIOCHEMISTRY

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stimulation of ribosomal frameshifting by RNA G-quadruplex structures

(2013) Chien-Hung Yu et al.   NUCLEIC ACIDS RESEARCH

Structure of the ribosome with elongation factor G trapped in the pretranslocation state

(2013) A. F. Brilot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies of translational misreading in vivo show that the ribosome very efficiently discriminates against most potential errors

(2013) N. Manickam et al.   RNA

Depletion of Cognate Charged Transfer RNA Causes Translational Frameshifting within the Expanded CAG Stretch in Huntingtin

(2013) Hannah Girstmair et al.   Cell Reports

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

(2013) Joshua G Dunn et al.   eLife

Allosteric control of the ribosome by small-molecule antibiotics

(2012) Leyi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence of abundant stop codon readthrough in Drosophila and other metazoa

(2011) I. Jungreis et al.   GENOME RESEARCH

The ribosome uses two active mechanisms to unwind messenger RNA during translation

(2011) Xiaohui Qu et al.   NATURE

mRNA translocation occurs during the second step of ribosomal intersubunit rotation

(2011) Dmitri N Ermolenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stimulation of stop codon readthrough: frequent presence of an extended 3′ RNA structural element

(2011) Andrew E. Firth et al.   NUCLEIC ACIDS RESEARCH

Conformational Sampling of Aminoacyl-tRNA during Selection on the Bacterial Ribosome

(2010) Peter Geggier et al.   JOURNAL OF MOLECULAR BIOLOGY

Visualizing high error levels during gene expression in living bacterial cells

(2010) M. Meyerovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways

(2010) P. C. Whitford et al.   RNA

The Mechanism for Activation of GTP Hydrolysis on the Ribosome

(2010) R. M. Voorhees et al.   SCIENCE

The evolutionary consequences of erroneous protein synthesis

(2009) D. Allan Drummond et al.   NATURE REVIEWS GENETICS

The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

(2009) T. M. Schmeing et al.   SCIENCE

PRFdb: A database of computationally predicted eukaryotic programmed -1 ribosomal frameshift signals

(2008) Ashton T Belew et al.   BMC GENOMICS

Coupling of Ribosomal L1 Stalk and tRNA Dynamics during Translation Elongation

(2008) Jingyi Fei et al.   MOLECULAR CELL

Spontaneous Intersubunit Rotation in Single Ribosomes

(2008) Peter V. Cornish et al.   MOLECULAR CELL

Quality control by the ribosome following peptide bond formation

(2008) Hani S. Zaher et al.   NATURE