Mammalian proteome expansion by stop codon readthrough

Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma

(2022) Onofrio Valente et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic promise of engineered nonsense suppressor tRNAs

(2021) Joseph J. Porter et al.   Wiley Interdisciplinary Reviews-RNA

Increased expression of tryptophan and tyrosine tRNAs elevates stop codon readthrough of reporter systems in human cell lines

(2021) Petra Beznosková et al.   NUCLEIC ACIDS RESEARCH

Increased fidelity of protein synthesis extends lifespan

(2021) Victoria Eugenia Martinez-Miguel et al.   Cell Metabolism

Mechanisms that ensure speed and fidelity in eukaryotic translation termination

(2021) Michael R. Lawson et al.   SCIENCE

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

(2021) Jyoti Sharma et al.   Nature Communications

Ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates the production of secondary siRNAs in plants

(2021) Hiro-oki Iwakawa et al.   Cell Reports

CRISPR-SCReT (CRISPR-Stop Codon Read Through) method to control Cas9 expression for gene editing

(2021) Pouiré Yaméogo et al.   GENE THERAPY

Tissue Distribution of the Readthrough Isoform of AQP4 Reveals a Dual Role of AQP4ex Limited to CNS

(2020) Claudia Palazzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy and safety of ataluren in patients with nonsense-mutation cystic fibrosis not receiving chronic inhaled aminoglycosides: The international, randomized, double-blind, placebo-controlled Ataluren Confirmatory Trial in Cystic Fibrosis (ACT CF)

(2020) M.W. Konstan et al.   Journal of Cystic Fibrosis

Translational read-through promotes aggregation and shapes stop codon identity

(2020) Lior Kramarski et al.   NUCLEIC ACIDS RESEARCH

Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

(2020) Jamie R Wangen et al.   eLife

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

(2020) Carole Trzaska et al.   Nature Communications

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

(2020) Chen Bao et al.   eLife

The roles of hnRNP A2 / B1 in RNA biology and disease

(2020) Yu Liu et al.   Wiley Interdisciplinary Reviews-RNA

CTELS: A Cell-Free System for the Analysis of Translation Termination Rate

(2020) Kseniya A. Lashkevich et al.   Biomolecules

Stop codon readthrough of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential

(2020) Lekha E Manjunath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay

(2020) Giuditta Annibaldis et al.   NUCLEIC ACIDS RESEARCH

Engineered transfer RNAs for suppression of premature termination codons

(2019) John D. Lueck et al.   Nature Communications

Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3

(2019) Christian Beißel et al.   NUCLEIC ACIDS RESEARCH

AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding

(2019) Claudia Palazzo et al.   Acta Neuropathologica Communications

Let‐7a‐regulated translational readthrough of mammalian AGO 1 generates a micro RNA pathway inhibitor

(2019) Anumeha Singh et al.   EMBO JOURNAL

New Negamycin-Based Potent Readthrough Derivative Effective against TGA-Type Nonsense Mutations

(2019) Keisuke Hamada et al.   ACS Medicinal Chemistry Letters

Induction of Translational Readthrough across the Thalassemia-Causing Premature Stop Codon in β-Globin-Encoding mRNA

(2019) Debaleena Kar et al.   BIOCHEMISTRY

Serum starvation enhances nonsense mutation readthrough

(2019) Amnon Wittenstein et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Selection for tandem stop codons in ciliate species with reassigned stop codons

(2019) Ira Fleming et al.   PLoS One

The novel aminoglycoside, ELX-02, permits CTNSW138X translational read-through and restores lysosomal cystine efflux in cystinosis

(2019) Emma J. Brasell et al.   PLoS One

Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol response

(2018) Gary Loughran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

(2018) Eugenio Mercuri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eukaryotic translational termination efficiency is influenced by the 3′ nucleotides within the ribosomal mRNA channel

(2018) Andrew G Cridge et al.   NUCLEIC ACIDS RESEARCH

Deciphering the reading of the genetic code by near-cognate tRNA

(2018) Sandra Blanchet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation Elongation and Recoding in Eukaryotes

(2018) Thomas E. Dever et al.   Cold Spring Harbor Perspectives in Biology

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

(2018) Martina M. Yordanova et al.   NATURE

A novel class of microRNA-recognition elements that function only within open reading frames

(2018) Kai Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Robustness by intrinsically disordered C-termini and translational readthrough

(2018) April Snofrid Kleppe et al.   NUCLEIC ACIDS RESEARCH

Roles of polyamines in translation

(2018) Thomas E. Dever et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational readthrough generates new astrocyte AQP4 isoforms that modulate supramolecular clustering, glial endfeet localization, and water transport

(2017) Manuela De Bellis et al.   GLIA

Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences

(2017) Xiaojiao Xue et al.   HUMAN MOLECULAR GENETICS

Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins

(2017) Jieshuang Jia et al.   JOURNAL OF CELL SCIENCE

Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Craig M McDonald et al.   LANCET

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ

(2017) Yoshihide Yamaguchi et al.   NEUROCHEMICAL RESEARCH

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

(2017) Richard S. Finkel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonsense-mediated mRNA decay: a ‘nonsense’ pathway makes sense in stem cell biology

(2017) Xin Han et al.   NUCLEIC ACIDS RESEARCH

MTCH2 is a conserved regulator of lipid homeostasis

(2017) Veerle Rottiers et al.   Obesity

Aminoglycoside interactions and impacts on the eukaryotic ribosome

(2017) Irina Prokhorova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation

(2017) Eder Mancera-Martínez et al.   RNA Biology

Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells

(2017) Laure Bidou et al.   RNA Biology

Avoidance of reporter assay distortions from fused dual reporters

(2017) Gary Loughran et al.   RNA

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes

(2016) Sichen Shao et al.   CELL

Evidence for Pro-angiogenic Functions of VEGF-Ax

(2016) Hong Xin et al.   CELL

Evolutionary Dynamics of Abundant Stop Codon Readthrough

(2016) Irwin Jungreis et al.   MOLECULAR BIOLOGY AND EVOLUTION

Translation readthrough mitigation

(2016) Joshua A. Arribere et al.   NATURE

RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes

(2016) Tatiana Mikhailova et al.   NUCLEIC ACIDS RESEARCH

PABP enhances release factor recruitment and stop codon recognition during translation termination

(2016) Alexandr Ivanov et al.   NUCLEIC ACIDS RESEARCH

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression

(2016) Bijoyita Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code

(2016) Julia Hofhuis et al.   Open Biology

Functional Translational Readthrough: A Systems Biology Perspective

(2016) Fabian Schueren et al.   PLoS Genetics

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders

(2015) Norihito Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways of Genetic Code Evolution in Ancient and Modern Organisms

(2015) Supratim Sengupta et al.   JOURNAL OF MOLECULAR EVOLUTION

Structural basis for stop codon recognition in eukaryotes

(2015) Alan Brown et al.   NATURE

Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning

(2015) Pavel V. Baranov et al.   NATURE REVIEWS GENETICS

Genetic code flexibility in microorganisms: novel mechanisms and impact on physiology

(2015) Jiqiang Ling et al.   NATURE REVIEWS MICROBIOLOGY

Translation initiation factor eIF3 promotes programmed stop codon readthrough

(2015) Petra Beznosková et al.   NUCLEIC ACIDS RESEARCH

Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes

(2015) Dmitry E Andreev et al.   GENOME BIOLOGY

Therapeutics Based on Stop Codon Readthrough

(2014) Kim M. Keeling et al.   Annual Review of Genomics and Human Genetics

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax

(2014) Sandeepa M. Eswarappa et al.   CELL

Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway

(2014) Ashton Trey Belew et al.   NATURE

Evidence of efficient stop codon readthrough in four mammalian genes

(2014) Gary Loughran et al.   NUCLEIC ACIDS RESEARCH

Selenoproteins: Molecular Pathways and Physiological Roles

(2014) Vyacheslav M. Labunskyy et al.   PHYSIOLOGICAL REVIEWS

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

(2014) C. Loenarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stop codon reassignments in the wild

(2014) N. N. Ivanova et al.   SCIENCE

Ribosomal Readthrough at a Short UGA Stop Codon Context Triggers Dual Localization of Metabolic Enzymes in Fungi and Animals

(2014) Alina C. Stiebler et al.   PLoS Genetics

Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals

(2014) Fabian Schueren et al.   eLife

Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression

(2013) Kim M. Keeling et al.   PLoS One

Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells

(2013) Petra Beznosková et al.   PLoS Genetics

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

(2013) Joshua G Dunn et al.   eLife

Polysome profiling reveals translational control of gene expression in the human malaria parasite Plasmodium falciparum

(2013) Evelien M Bunnik et al.   GENOME BIOLOGY

L-MPZ, a Novel Isoform of Myelin P0, Is Produced by Stop Codon Readthrough

(2012) Yoshihide Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical translation in RNA viruses

(2012) A. E. Firth et al.   JOURNAL OF GENERAL VIROLOGY

Rescue of nonsense mutations by amlexanox in human cells

(2012) Sara Gonzalez-Hilarion et al.   Orphanet Journal of Rare Diseases

Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin

(2012) Célia Floquet et al.   PLoS Genetics

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

The pyrrolysine translational machinery as a genetic-code expansion tool

(2011) Tomasz Fekner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Tandem termination signal in plant mRNAs

(2011) Alex V. Kochetov et al.   GENE

Evidence of abundant stop codon readthrough in Drosophila and other metazoa

(2011) I. Jungreis et al.   GENOME RESEARCH

Alternative Fates of Paused Ribosomes during Translation Termination

(2011) Jason S. Seidman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Converting nonsense codons into sense codons by targeted pseudouridylation

(2011) John Karijolich et al.   NATURE

An equilibrium-dependent retroviral mRNA switch regulates translational recoding

(2011) Brian Houck-Loomis et al.   NATURE

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Stimulation of stop codon readthrough: frequent presence of an extended 3′ RNA structural element

(2011) Andrew E. Firth et al.   NUCLEIC ACIDS RESEARCH

Evolution of molecular error rates and the consequences for evolvability

(2011) E. Rajon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases

(2011) Kim M. Keeling et al.   Wiley Interdisciplinary Reviews-RNA

Ataluren (PTC124) Induces Cystic Fibrosis Transmembrane Conductance Regulator Protein Expression and Activity in Children with Nonsense Mutation Cystic Fibrosis

(2010) Isabelle Sermet-Gaudelus et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy

(2010) Vinod Malik et al.   ANNALS OF NEUROLOGY

Implication of Genetic Variants NearNEGR1,SEC16B,TMEM18,ETV5/DGKG,GNPDA2,LIN7C/BDNF,MTCH2,BCDIN3D/FAIM2,SH2B1,FTO,MC4R, andKCTD15with Obesity and Type 2 Diabetes in 7705 Chinese

(2010) Maggie C. Y. Ng et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

(2010) Yehudit Zaltsman et al.   NATURE CELL BIOLOGY

Three distinct peptides from the N domain of translation termination factor eRF1 surround stop codon in the ribosome

(2010) K. N. Bulygin et al.   RNA

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

A meta-analysis of nonsense mutations causing human genetic disease

(2008) Matthew Mort et al.   HUMAN MUTATION

Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial

(2008) Eitan Kerem et al.   LANCET

PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model

(2008) M. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA