The Metabolostasis Network and the Cellular Depository of Aggregation‐Prone Metabolites

Entropically-Driven Co-assembly of l-Histidine and l-Phenylalanine to Form Supramolecular Materials

(2023) Om Shanker Tiwari et al.   ACS Nano

Stability matters, too - The thermodynamics of amyloid fibril formation

(2022) Alexander Buell   Chemical Science

Amyloids Formed by Nonaromatic Amino Acid Methionine and Its Cross with Phenylalanine Significantly Affects Phospholipid Vesicle Membrane: An Insight into Hypermethioninemia Disorder

(2022) Sourav Nandi et al.   LANGMUIR

Dysmyelination and glycolipid interference caused by phenylalanine in phenylketonuria

(2022) Valeria Rondelli et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Genesis of Neurotoxic Hybrid Nanofibers from the Coassembly of Aromatic Amino Acids

(2021) Bibin Gnanadhason Anand et al.   ACS Applied Materials & Interfaces

Unusual Aggregates Formed by the Self-Assembly of Proline, Hydroxyproline, and Lysine

(2021) Bharti Koshti et al.   ACS Chemical Neuroscience

Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation

(2021) Ashim Paul et al.   ACS Nano

Chemical Chaperones Modulate the Formation of Metabolite Assemblies

(2021) Hanaa Adsi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress

(2021) Max-Hinderk Schuler et al.   MOLECULAR CELL

Homocysteine fibrillar assemblies display cross-talk with Alzheimer’s disease β-amyloid polypeptide

(2021) Dorin Sade Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules

(2021) Dor Zaguri et al.   ACS Nano

Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport

(2021) Stefan Bröer et al.   JOURNAL OF NUTRITION

Understanding the Self-Assembling Behavior of Biological Building Block Molecules: A Spectroscopic and Microscopic Approach

(2020) Pavel Banerjee et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Antagonist Effects of l-Phenylalanine and the Enantiomeric Mixture Containing d-Phenylalanine on Phospholipid Vesicle Membrane

(2020) Sourav Nandi et al.   LANGMUIR

Nanomechanical Properties and Phase Behavior of Phenylalanine Amyloid Ribbon Assemblies and Amorphous Self-Healing Hydrogels

(2020) Dor Zaguri et al.   ACS Applied Materials & Interfaces

α-Synuclein aggregation nucleates through liquid–liquid phase separation

(2020) Soumik Ray et al.   Nature Chemistry

Growth Inhibition by Amino Acids in Saccharomyces cerevisiae

(2020) Stephanie J. Ruiz et al.   Microorganisms

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

(2019) Dana Laor et al.   Nature Communications

Mechanisms of Metabolite Amyloid Formation: Computational Studies for Drug Design against Metabolic Disorders

(2019) Massimiliano Meli et al.   ACS Medicinal Chemistry Letters

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Self-Assembly of Artificial Sweetener Aspartame Yields Amyloid-like Cytotoxic Nanostructures

(2019) Bibin Gnanadhason Anand et al.   ACS Nano

Rigid Tightly Packed Amino Acid Crystals as Functional Supramolecular Materials

(2019) Wei Ji et al.   ACS Nano

Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation

(2019) Chengqian Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of Amino Acid Transport in Saccharomyces cerevisiae

(2019) Frans Bianchi et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies

(2018) Shreyasi Asthana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Metabolite amyloid-like fibrils interact with model membranes

(2018) Shira Shaham-Niv et al.   CHEMICAL COMMUNICATIONS

A proposed nosology of inborn errors of metabolism

(2018) Carlos R. Ferreira et al.   GENETICS IN MEDICINE

Inborn errors of metabolism and the human interactome: a systems medicine approach

(2018) Mathias Woidy et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Antibodies towards Tyrosine Amyloid-Like Fibrils Allow Toxicity Modulation and Cellular Imaging of the Assemblies

(2018) Dor Zaguri et al.   MOLECULES

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

(2018) Johnny Habchi et al.   Nature Chemistry

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

Seeding of proteins into amyloid structures by metabolite assemblies may clarify certain unexplained epidemiological associations

(2018) Dorin Sade et al.   Open Biology

The Insoluble Protein Deposit (IPOD) in Yeast

(2018) Stephanie Rothe et al.   Frontiers in Molecular Neuroscience

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

(2018) Alexandra Moreno-García et al.   Frontiers in Neuroscience

Organization of Amino Acids into Layered Supramolecular Secondary Structures

(2018) Santu Bera et al.   ACCOUNTS OF CHEMICAL RESEARCH

Intrinsic Fluorescence of Metabolite Amyloids Allows Label-Free Monitoring of Their Formation and Dynamics in Live Cells

(2018) Shira Shaham-Niv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation

(2018) Omid Tavassoly et al.   JOURNAL OF MOLECULAR BIOLOGY

An Approach to Defining the Upper Safe Limits of Amino Acid Intake

(2018) Paul B. Pencharz et al.   JOURNAL OF NUTRITION

Amyloid-like Structures Formed by Single Amino Acid Self-Assemblies of Cysteine and Methionine

(2018) Nidhi Gour et al.   ACS Chemical Neuroscience

Proteins evolve on the edge of supramolecular self-assembly

(2017) Hector Garcia-Seisdedos et al.   NATURE

Control of piezoelectricity in amino acids by supramolecular packing

(2017) Sarah Guerin et al.   NATURE MATERIALS

Intrinsic property of phenylalanine to trigger protein aggregation and hemolysis has a direct relevance to phenylketonuria

(2017) Bibin G. Anand et al.   Scientific Reports

Formation of Apoptosis-Inducing Amyloid Fibrils by Tryptophan

(2016) Shira Shaham-Niv et al.   ISRAEL JOURNAL OF CHEMISTRY

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Phenylalanine Oligomers and Fibrils: The Mechanism of Assembly and the Importance of Tetramers and Counterions

(2015) Thanh D. Do et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria

(2015) Ada De Luigi et al.   Scientific Reports

Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies

(2015) S. Shaham-Niv et al.   Science Advances

Inborn errors of metabolism identified via newborn screening: Ten-year incidence data and costs of nutritional interventions for research agenda planning

(2014) Bradford L. Therrell et al.   MOLECULAR GENETICS AND METABOLISM

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria

(2014) Virender Singh et al.   Scientific Reports

Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae

(2012) P. O. Ljungdahl et al.   GENETICS

Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

(2012) Lihi Adler-Abramovich et al.   Nature Chemical Biology

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

(2011) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrophobicity and Charge Shape Cellular Metabolite Concentrations

(2011) Arren Bar-Even et al.   PLoS Computational Biology

The solubility of nucleobases in aqueous arginine solutions

(2010) Atsushi Hirano et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine Increases the Solubility of Coumarin: Comparison with Salting-in and Salting-out Additives

(2008) A. Hirano et al.   JOURNAL OF BIOCHEMISTRY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Solubility enhancement of gluten and organic compounds by arginine

(2007) Tsutomu Arakawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS