Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

(2018) Can Kayatekin et al.   CELL

Metabolite amyloid-like fibrils interact with model membranes

(2018) Shira Shaham-Niv et al.   CHEMICAL COMMUNICATIONS

Side-chain effects on the structures of protonated amino acid dimers: A gas-phase infrared spectroscopy study

(2018) Jongcheol Seo et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Antibodies towards Tyrosine Amyloid-Like Fibrils Allow Toxicity Modulation and Cellular Imaging of the Assemblies

(2018) Dor Zaguri et al.   MOLECULES

Investigation of Fibril Forming Mechanisms of l-Phenylalanine and l-Tyrosine: Microscopic Insight toward Phenylketonuria and Tyrosinemia Type II

(2017) Debasis Banik et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Self-assembly of aromatic α-amino acids into amyloid inspired nano/micro scaled architects

(2017) Prabhjot Singh et al.   Materials Science & Engineering C-Materials for Biological Applications

Formation of Apoptosis-Inducing Amyloid Fibrils by Tryptophan

(2016) Shira Shaham-Niv et al.   ISRAEL JOURNAL OF CHEMISTRY

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation

(2016) Anđela Šarić et al.   JOURNAL OF CHEMICAL PHYSICS

Metabolite amyloids: a new paradigm for inborn error of metabolism disorders

(2016) Ehud Gazit   JOURNAL OF INHERITED METABOLIC DISEASE

Inhibition of Fibrillar Assemblies of l-Phenylalanine by Crown Ethers: A Potential Approach toward Phenylketonuria

(2016) Debasis Banik et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Modulation of the Excited-State Dynamics of 2,2′-Bipyridine-3,3′-diol in Crown Ethers: A Possible Way To Control the Morphology of a Glycine Fibril through Fluorescence Lifetime Imaging Microscopy

(2016) Debasis Banik et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Availability of Amino Acids Extends Chronological Lifespan by Suppressing Hyper-Acidification of the Environment in Saccharomyces cerevisiae

(2016) Yo Maruyama et al.   PLoS One

Label-free Chemical Imaging of Fungal Spore Walls by Raman Microscopy and Multivariate Curve Resolution Analysis

(2016) Hemanth Noothalapati et al.   Scientific Reports

Essential amino acids: master regulators of nutrition and environmental footprint?

(2016) Paolo Tessari et al.   Scientific Reports

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Self-Assembly of Tyrosine into Controlled Supramolecular Nanostructures

(2015) Cécilia Ménard-Moyon  et al.   CHEMISTRY-A EUROPEAN JOURNAL

Circular Dichroism of Amino Acids: Following the Structural Formation of Phenylalanine

(2015) Nadav Amdursky et al.   CHEMPHYSCHEM

Phenylalanine interaction with lipid monolayers at different pHs

(2015) A.C. Cutró et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring

(2015) Parinya Panuwet et al.   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY

Interaction of Phenylalanine with DPPC Model Membranes: More Than a Hydrophobic Interaction

(2015) A. S. Rosa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Phenylalanine Oligomers and Fibrils: The Mechanism of Assembly and the Importance of Tetramers and Counterions

(2015) Thanh D. Do et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fibrils of Phenylalanine Adsorbed to Langmuir-Blodgett Films: Role of Lipids

(2015) Kamatchi Sankaranarayanan   SOFT MATERIALS

Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria

(2015) Ada De Luigi et al.   Scientific Reports

Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies

(2015) S. Shaham-Niv et al.   Science Advances

Fluorescent dye ProteoStat to detect and discriminate intracellular amyloid-like aggregates inEscherichia coli

(2014) Susanna Navarro et al.   Biotechnology Journal

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenine phosphoribosyltransferase (APRT) deficiency: identification of a novel nonsense mutation

(2014) Rea Valaperta et al.   BMC Nephrology

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Stable Isotope-Labeled Raman Imaging Reveals Dynamic Proteome Localization to Lipid Droplets in Single Fission Yeast Cells

(2012) Hemanth Nag Noothalapati Venkata et al.   CHEMISTRY & BIOLOGY

A yeast model for amyloid-  aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity

(2012) F. D'Angelo et al.   Disease Models & Mechanisms

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

(2012) Lihi Adler-Abramovich et al.   Nature Chemical Biology

A Diversity of Assembly Mechanisms of a Generic Amyloid Fold

(2011) Timo Eichner et al.   MOLECULAR CELL

Strain conformation, primary structure and the propagation of the yeast prion [PSI+]

(2011) Katherine J Verges et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

(2010) Vikram Khurana et al.   NATURE REVIEWS NEUROSCIENCE

Prion-like mechanisms in neurodegenerative diseases

(2009) Bess Frost et al.   NATURE REVIEWS NEUROSCIENCE