Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation

Homocysteine fibrillar assemblies display cross-talk with Alzheimer’s disease β-amyloid polypeptide

(2021) Dorin Sade Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biochemical basis of interactions between Glucocerebrosidase and alpha‐synuclein in GBA 1 mutation carriers

(2020) Marco Toffoli et al.   JOURNAL OF NEUROCHEMISTRY

Naphthoquinone‐Dopamine hybrids inhibit α‐synuclein aggregation, disrupt preformed fibrils and attenuate aggregate‐induced toxicity

(2020) Ashim Paul et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploring polar headgroup interactions between sphingomyelin and ceramide with infrared spectroscopy

(2020) Igor de la Arada et al.   Scientific Reports

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

(2019) Dana Laor et al.   Nature Communications

Formation of tubules and helical ribbons by ceramide phosphoethanolamine-containing membranes

(2019) Takehiko Inaba et al.   Scientific Reports

His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria

(2019) Kaja Przygońska et al.   Scientific Reports

Ambroxol improves skeletal and hematological manifestations on a child with Gaucher disease

(2019) Wenjun Jiang et al.   JOURNAL OF HUMAN GENETICS

Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

(2019) Michael X. Henderson et al.   NEURON

Probing the role of ceramide hydroxylation in skin barrier lipid models by 2 H solid-state NMR spectroscopy and X-ray powder diffraction

(2018) Andrej Kováčik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of glucocerebrosidase in Parkinson disease pathogenesis

(2018) Matthew E. Gegg et al.   FEBS Journal

Allantoin and hydantoin as new protein aggregation suppressors

(2018) Suguru Nishinami et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inborn errors of metabolism and the human interactome: a systems medicine approach

(2018) Mathias Woidy et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

(2018) Friederike Zunke et al.   NEURON

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins

(2018) Gaetano Malgieri et al.   Chemical Science

Structural characteristics and membrane interactions of tandem α-synuclein oligomers

(2018) Chunhua Dong et al.   Scientific Reports

Seeding of proteins into amyloid structures by metabolite assemblies may clarify certain unexplained epidemiological associations

(2018) Dorin Sade et al.   Open Biology

Outcomes after 8 Years of Eliglustat Therapy for Gaucher Disease Type 1: Final Results from the Phase 2 Trial

(2018) Elena Lukina et al.   AMERICAN JOURNAL OF HEMATOLOGY

Ganglioside lipids accelerate α-synuclein amyloid formation

(2018) Ricardo Gaspar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation

(2018) Omid Tavassoly et al.   JOURNAL OF MOLECULAR BIOLOGY

Congo Red and amyloids: history and relationship

(2018) Elmira I. Yakupova et al.   BIOSCIENCE REPORTS

Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules

(2017) Sayanti Brahmachari et al.   Future Medicinal Chemistry

Gallic acid induced dose dependent inhibition of lysozyme fibrillation

(2017) Mouli Konar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease

(2017) Yumiko V. Taguchi et al.   JOURNAL OF NEUROSCIENCE

Gaucher disease: Progress and ongoing challenges

(2017) Pramod K. Mistry et al.   MOLECULAR GENETICS AND METABOLISM

CH/π Interactions in Carbohydrate Recognition

(2017) Vojtěch Spiwok   MOLECULES

Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity

(2017) Masahiro Nagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic property of phenylalanine to trigger protein aggregation and hemolysis has a direct relevance to phenylketonuria

(2017) Bibin G. Anand et al.   Scientific Reports

Glucosylsphingosine is a key biomarker of Gaucher disease

(2016) Vagishwari Murugesan et al.   AMERICAN JOURNAL OF HEMATOLOGY

Effect of acidic pH on the stability of α-synuclein dimers

(2016) Zhengjian Lv et al.   BIOPOLYMERS

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease

(2016) Joana Magalhaes et al.   HUMAN MOLECULAR GENETICS

Formation of Apoptosis-Inducing Amyloid Fibrils by Tryptophan

(2016) Shira Shaham-Niv et al.   ISRAEL JOURNAL OF CHEMISTRY

The relationship between glucocerebrosidase mutations and Parkinson disease

(2016) Anna Migdalska-Richards et al.   JOURNAL OF NEUROCHEMISTRY

Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria

(2015) Ada De Luigi et al.   Scientific Reports

Metastability in lipid based particles exhibits temporally deterministic and controllable behavior

(2015) Guy Jacoby et al.   Scientific Reports

Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies

(2015) S. Shaham-Niv et al.   Science Advances

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CH–π hydrogen bonds in biological macromolecules

(2014) Motohiro Nishio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid crystal assemblies in biologically inspired systems

(2013) Cyrus R. Safinya et al.   LIQUID CRYSTALS

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

(2012) Lihi Adler-Abramovich et al.   Nature Chemical Biology

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

An X-ray diffraction study of model membrane raft structures

(2010) Peter J. Quinn et al.   FEBS Journal

Impact of the long chain ω-acylceramides on the stratum corneum lipid nanostructure. Part 1: Thermotropic phase behaviour of CER[EOS] and CER[EOP] studied using X-ray powder diffraction and FT-Raman spectroscopy

(2009) Doreen Kessner et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Structural Reorganization of α-Synuclein at Low pH Observed by NMR and REMD Simulations

(2009) Kuen-Phon Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Scatterless hybrid metal–single-crystal slit for small-angle X-ray scattering and high-resolution X-ray diffraction

(2008) Youli Li et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Phenotype, diagnosis, and treatment of Gaucher's disease

(2008) Gregory A Grabowski   LANCET