Inborn errors of metabolism and the human interactome: a systems medicine approach

Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells

(2018) Martina Zandl-Lang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Two new cases of mitochondrial myopathy with exercise intolerance, hyperlactatemia and cardiomyopathy, caused by recessive SLC25A4 mutations

(2018) Anouk Tosserams et al.   MITOCHONDRION

In VivoModeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease

(2017) Stephen W. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteome-Scale Human Interactomics

(2017) Katja Luck et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number

(2016) Kyle Thompson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Next Generation Multiscale View of Inborn Errors of Metabolism

(2016) Carmen A. Argmann et al.   Cell Metabolism

Uncovering disease mechanisms through network biology in the era of Next Generation Sequencing

(2016) Janet Piñero et al.   Scientific Reports

Endophenotype Network Models: Common Core of Complex Diseases

(2016) Susan Dina Ghiassian et al.   Scientific Reports

Tissue Specificity of Human Disease Module

(2016) Maksim Kitsak et al.   Scientific Reports

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma

(2015) Amitabh Sharma et al.   HUMAN MOLECULAR GENETICS

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

Endoplasmic Reticulum Stress Mediates Amyloid β Neurotoxicity via Mitochondrial Cholesterol Trafficking

(2014) Elisabet Barbero-Camps et al.   AMERICAN JOURNAL OF PATHOLOGY

Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening

(2014) Ying Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

(2014) Petroula Proitsi et al.   PLOS MEDICINE

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup

(2013) Kevin A. Strauss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

(2013) Bruce Reed et al.   JAMA Neurology

Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent

(2011) DJ Hausenloy et al.   BRITISH JOURNAL OF PHARMACOLOGY

SnapShot: Protein-Protein Interaction Networks

(2011) Jan Seebacher et al.   CELL

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Cyclosporine-A as a neuroprotective agent against stroke: Its translation from laboratory research to clinical application

(2011) Mohamed M. Osman et al.   NEUROPEPTIDES

Using graph theory to analyze biological networks

(2011) Georgios A Pavlopoulos et al.   BioData Mining

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies

(2008) Luciano Merlini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network properties of genes harboring inherited disease mutations

(2008) I. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA