Seeding of proteins into amyloid structures by metabolite assemblies may clarify certain unexplained epidemiological associations

The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice

(2017) Khoosheh Khayati et al.   FASEB JOURNAL

Changes in kynurenine pathway metabolism in Parkinson patients with L-DOPA-induced dyskinesia

(2017) Jesper F. Havelund et al.   JOURNAL OF NEUROCHEMISTRY

Investigation of Fibril Forming Mechanisms of l-Phenylalanine and l-Tyrosine: Microscopic Insight toward Phenylketonuria and Tyrosinemia Type II

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Self-Assembly, Hydrogelation, and Nanotube Formation by Cation-Modified Phenylalanine Derivatives

(2017) Annada Rajbhandary et al.   LANGMUIR

Self-assembly of aromatic α-amino acids into amyloid inspired nano/micro scaled architects

(2017) Prabhjot Singh et al.   Materials Science & Engineering C-Materials for Biological Applications

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

(2017) Danielle E Mor et al.   NATURE NEUROSCIENCE

A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson’s Disease

(2017) Dolores Vilas et al.   Journal of Parkinsons Disease

Self-assembled nanotubes from single fluorescent amino acid

(2017) Dipak Gorakh Babar et al.   Applied Nanoscience

Gout: An old disease in new perspective – A review

(2017) Gaafar Ragab et al.   Journal of Advanced Research

Intrinsic property of phenylalanine to trigger protein aggregation and hemolysis has a direct relevance to phenylketonuria

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Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain

(2016) Stefano Patassini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

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Formation of Apoptosis-Inducing Amyloid Fibrils by Tryptophan

(2016) Shira Shaham-Niv et al.   ISRAEL JOURNAL OF CHEMISTRY

Toxicity of serum albumin on microglia upon seeding effect of amyloid peptide

(2016) Maryam Ferdousi et al.   JOURNAL OF BIOCHEMISTRY

Metabolite amyloids: a new paradigm for inborn error of metabolism disorders

(2016) Ehud Gazit   JOURNAL OF INHERITED METABOLIC DISEASE

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

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Self-Assembly of Tyrosine into Controlled Supramolecular Nanostructures

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Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria

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Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies

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Evidence of Rapid Coaggregation of Globular Proteins during Amyloid Formation

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Early nitisinone treatment reduces the need for liver transplantation in children with tyrosinaemia type 1 and improves post-transplant renal function

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The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism

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Fluctuations in phenylalanine concentrations in phenylketonuria: A review of possible relationships with outcomes

(2013) Maureen Cleary et al.   MOLECULAR GENETICS AND METABOLISM

Structural Insights into the Folding Defects of Oncogenic pVHL Lead to Correction of Its Function In Vitro

(2013) Merav D. Shmueli et al.   PLoS One

Single amino acid based self-assembled structure

(2013) Shama Perween et al.   Soft Matter

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

EvaluatingDrosophilap53 as a Model System for Studying Cancer Mutations

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The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations

(2012) Lin Tan et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

(2012) Lihi Adler-Abramovich et al.   Nature Chemical Biology

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

(2011) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

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Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?

(2011) Jia-Min Zhuo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

(2010) Jeremy H Toyn et al.   BMC NEUROSCIENCE

The reality of dietary compliance in the management of phenylketonuria

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Hyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain

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Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol

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Hyperhomocysteinemia and Alzheimer's disease: A systematic review

(2008) Floris Van Dam et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Liver Tumors in Children

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