Uric acid transport, transporters, and their pharmacological targeting

The Human ATP‐Binding Cassette (ABC) Transporter Superfamily

(2022) Michael Dean et al.   HUMAN MUTATION

Genetic Basis of the Epidemiological Features and Clinical Significance of Renal Hypouricemia

(2022) Masayuki Hakoda et al.   Biomedicines

Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)

(2021) David Drew et al.   CHEMICAL REVIEWS

Effects of losartan and enalapril on serum uric acid and GFR in children with proteinuria

(2021) Charlotte E. Bryant et al.   PEDIATRIC NEPHROLOGY

Uric acid-lowering effect of dotinurad, a novel selective urate reabsorption inhibitor, in hypertensive patients with gout or asymptomatic hyperuricemia: a pooled analysis of individual participant data in phase II and III trials

(2021) Toshinari Takahashi et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity

(2020) Junichiro Uda et al.   ACS Medicinal Chemistry Letters

A guide to plasma membrane solute carrier proteins

(2020) Mattia D. Pizzagalli et al.   FEBS Journal

Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1

(2020) Ze’an Zhao et al.   ACS Omega

Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium–coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12)

(2019) Sunena Srivastava et al.   Journal of Physiological Sciences

Uric acid and the cardio‐renal effects of SGLT2 inhibitors

(2019) Clifford J. Bailey   DIABETES OBESITY & METABOLISM

Pharmacological evaluation of dotinurad, a selective urate reabsorption inhibitor

(2019) Tetsuya Taniguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glucocorticoids increase renal excretion of urate in mice by down-regulating urate transporter 1

(2019) Gentao Li et al.   DRUG METABOLISM AND DISPOSITION

Gout

(2019) Nicola Dalbeth et al.   Nature Reviews Disease Primers

Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: an exploratory, randomized, multicenter, double-blind, placebo-controlled, parallel-group early phase 2 study

(2019) Tatsuo Hosoya et al.   Clinical and Experimental Nephrology

Open-label study of long-term administration of dotinurad in Japanese hyperuricemic patients with or without gout

(2019) Tatsuo Hosoya et al.   Clinical and Experimental Nephrology

Renal effects of SGLT2 inhibitors

(2019) Josselin Nespoux et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney

(2018) Muriel Auberson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans

(2018) Vishal Shah et al.   XENOBIOTICA

Safety and efficacy of verinurad, a selective URAT1 inhibitor, for the treatment of patients with gout and/or asymptomatic hyperuricemia in the United States and Japan: Findings from two phase II trials

(2018) David Fitz-Patrick et al.   Modern Rheumatology

Molecular Mechanism of ATP Hydrolysis in an ABC Transporter

(2018) Marten Prieß et al.   ACS Central Science

Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men

(2017) Callum Tanner et al.   Arthritis & Rheumatology

Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout

(2017) Philip K. Tan et al.   Scientific Reports

Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study)

(2016) Thomas Bardin et al.   ANNALS OF THE RHEUMATIC DISEASES

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

Expression of a human NPT1/SLC17A1 missense variant which increases urate export

(2016) Masayuki Sakiyama et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Uric acid transporters hiding in the intestine

(2016) Xianxiang Xu et al.   PHARMACEUTICAL BIOLOGY

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

(2016) Michael Gillen et al.   Drug Design Development and Therapy

Intestinal Microbiota Distinguish Gout Patients from Healthy Humans

(2016) Zhuang Guo et al.   Scientific Reports

Lesinurad Combined With Allopurinol: A Randomized, Double-Blind, Placebo-Controlled Study in Gout Patients With an Inadequate Response to Standard-of-Care Allopurinol (a US-Based Study)

(2016) Kenneth G. Saag et al.   Arthritis & Rheumatology

Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations

(2016) Hiroshi Miyata et al.   Frontiers in Pharmacology

Investigational drugs for hyperuricemia

(2015) Hania Shahid et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

(2015) Sanjay K. Nigam et al.   PHYSIOLOGICAL REVIEWS

Hyperuricemia: A Biomarker of Renal Hemodynamic Impairment

(2015) Dinko Susic et al.   CardioRenal Medicine

High frequency of SLC22A12 variants causing renal hypouricemia 1 in the Czech and Slovak Roma population; simple and rapid detection method by allele-specific polymerase chain reaction

(2015) Dana Gabrikova et al.   Urolithiasis

A Review of Uric Acid, Crystal Deposition Disease, and Gout

(2014) Fernando Perez-Ruiz et al.   ADVANCES IN THERAPY

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9

(2014) Brian J DeBosch et al.   Nature Communications

NPT1/SLC17A1 Is a Renal Urate Exporter in Humans and Its Common Gain-of-Function Variant Decreases the Risk of Renal Underexcretion Gout

(2014) Toshinori Chiba et al.   Arthritis & Rheumatology

Common Folds and Transport Mechanisms of Secondary Active Transporters

(2013) Yigong Shi   Annual Review of Biophysics

Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease

(2013) Hirofumi Yano et al.   Clinical and Experimental Nephrology

A Common Variant of Organic Anion Transporter 4 (OAT4/SLC22A11) Gene Is Associated with Renal Underexcretion Type Gout

(2013) Masayuki Sakiyama et al.   Drug Metabolism and Pharmacokinetics

Uric acid and risk of heart failure: a systematic review and meta-analysis

(2013) He Huang et al.   EUROPEAN JOURNAL OF HEART FAILURE

Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate

(2012) Yang Lu et al.   Drug Metabolism and Pharmacokinetics

Extra-Renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2

(2012) Atsushi Hosomi et al.   PLoS One

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

(2011) Adrienne Tin et al.   HUMAN MOLECULAR GENETICS

Pathogenic GLUT9 Mutations Causing Renal Hypouricemia Type 2 (RHUC2)

(2011) Y. Kawamura et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

ABCG2 is a High-Capacity Urate Transporter and its Genetic Impairment Increases Serum Uric Acid Levels in Humans

(2011) Akiyoshi Nakayama et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

Human Sodium Phosphate Transporter 4 (hNPT4/SLC17A3) as a Common Renal Secretory Pathway for Drugs and Urate

(2010) Promsuk Jutabha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 Sodium-dependent Phosphate Transporter (SLC17A1 Protein) Is a Cl−-dependent Urate Exporter

(2010) Masafumi Iharada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

URAT1 mutations cause renal hypouricemia type 1 in Iraqi Jews

(2010) D. Dinour et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Establishment and Analysis ofSLC22A12(URAT1) Knockout Mouse

(2010) M. Hosoyamada et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Facilitative glucose transporter 9, a unique hexose and urate transporter

(2009) Manuel Doblado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout

(2009) W. Urano et al.   ANNALS OF THE RHEUMATIC DISEASES

Homozygous SLC2A9 Mutations Cause Severe Renal Hypouricemia

(2009) D. Dinour et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans

(2008) Naohiko Anzai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

Structure and mechanism of ATP-binding cassette transporters

(2008) K. P Locher   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SLC2A9 Is a High-Capacity Urate Transporter in Humans

(2008) Mark J Caulfield et al.   PLOS MEDICINE

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane

(2007) M. Huls et al.   KIDNEY INTERNATIONAL