Article
Chemistry, Medicinal
Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang
Summary: The study demonstrated that fucoidan (FPS) effectively inhibits the expression induction of urate transporters URAT1 and GLUT9 induced by uric acid, through repressing the activation of NF-kappa B, JNK, and PI3K/Akt signal pathways.
Article
Biochemistry & Molecular Biology
Antonia Costa-Bauza, Paula Calvo, Yumaira Hernandez, Felix Grases
Summary: Uric acid lithiasis is a common type of renal lithiasis, often caused by low urinary pH, high concentration of urinary uric acid, and low diuresis. Treatment options include alkalinization of urine, reducing consumption of purine-rich foods, and administration of xanthine oxidase inhibitors. Theobromine has been found to inhibit uric acid crystallization and reduce the risk of uric acid lithiasis. The study evaluated the effects of theobromine metabolites and other methylxanthine-related compounds on uric acid crystallization and measured their concentrations in urine samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ze An Zhao, Yu Jiang, Yan-yu Chen, Ting Wu, Qun-sheng Lan, Yong-mei Li, Lu Li, Yang Yang, Cui-ting Lin, Ying Cao, Ping-zheng Zhou, Jia-yin Guo, Yuan-xin Tian, Jian-xin Pang
Summary: The newly synthesized CDER167, a dual-target inhibitor of URAT1 and GLUT9, showed potent uric acid-lowering effects with favorable pharmacokinetic properties. CDER167 demonstrated significant inhibitory effects on both URAT1 and GLUT9, with detailed interaction mechanisms elucidated. The study suggests CDER167 as a promising candidate for further development as an antihyperuricemic drug targeting URAT1 and GLUT9.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Jin-Woo Park, Ji-Hyeon Noh, Jong-Min Kim, Hwa-Young Lee, Kyoung-Ah Kim, Ji-Young Park
Summary: This study found that the polymorphisms of ABCG2 rs2231142 and SLC2A9 rs3733591 may elevate blood uric acid levels.
Article
Cell Biology
Benjamin P. Luescher, Christiane Albrecht, Bruno Stieger, Daniel V. Surbek, Marc U. Baumann
Summary: This study reveals the efficient role of the placental uric acid transport system in maintaining uric acid homeostasis, with GLUT9 playing a crucial role in this process. Further investigation on the role of the placental uric acid transport system in preeclampsia is urgently needed.
Article
Genetics & Heredity
Yu Toyoda, Sung Kweon Cho, Velibor Tasic, Katerina Pavelcova, Jana Bohata, Hiroshi Suzuki, Victor A. David, Jaeho Yoon, Anna Pallaiova, Jana Saligova, Darryl Nousome, Raul Cachau, Cheryl A. Winkler, Tappei Takada, Blanka Stiburkova
Summary: Renal hypouricemia (RHUC) is a pathological condition characterized by extremely low serum urate and overexcretion of urate in the kidney. In this study, a familial case of RHUC type 2 was described, and an intronic GLUT9 variant, c.1419+1G > A, was identified as the causal mutation that resulted in a functionally-null variant. This finding enhances our understanding of RHUC and the importance of GLUT9 in its pathophysiology.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Michael A. Schwarzschild, Alberto Ascherio, Cindy Casaceli, Gary C. Curhan, Rebecca Fitzgerald, Cornelia Kamp, Codrin Lungu, Eric A. Macklin, Kenneth Marek, Dariush Mozaffarian, David Oakes, Alice Rudolph, Ira Shoulson, Aleksandar Videnovic, Burton Scott, Lisa Gauger, Jason Aldred, Melissa Bixby, Jill Ciccarello, Steven A. Gunzler, Claire Henchcliffe, Matthew Brodsky, Kellie Keith, Robert A. Hauser, Christopher Goetz, Mark S. LeDoux, Vanessa Hinson, Rajeev Kumar, Alberto J. Espay, Joohi Jimenez-Shahed, Christine Hunter, Chadwick Christine, Aaron Daley, Maureen Leehey, J. Antonelle de Marcaida, Joseph Harold Friedman, Albert Hung, Grace Bwala, Irene Litvan, David K. Simon, Tanya Simuni, Cynthia Poon, Mya C. Schiess, Kelvin Chou, Ariane Park, Danish Bhatti, Carolyn Peterson, Susan R. Criswell, Liana Rosenthal, Jennifer Durphy, Holly A. Shill, Shyamal H. Mehta, Anwar Ahmed, Andres F. Deik, John Y. Fang, Natividad Stover, Lin Zhang, Richard B. Dewey, Ashley Gerald, James T. Boyd, Emily Houston, Valerie Suski, Sherri Mosovsky, Leslie Cloud, Binit B. Shah, Marie Saint-Hilaire, Raymond James, Sarah Elizabeth Zauber, Stephen Reich, David Shprecher, Rajesh Pahwa, April Langhammer, Kathrin LaFaver, Peter A. LeWitt, Patricia Kaminski, John Goudreau, Doozie Russell, David J. Houghton, Ashley Laroche, Karen Thomas, Martha McGraw, Zoltan Mari, Carmen Serrano, Karen Blindauer, Marcie Rabin, Roger Kurlan, John C. Morgan, Michael Soileau, Melissa Ainslie, Ivan Bodis-Wollner, Ruth B. Schneider, Cheryl Waters, Amber Servi Ratel, Christopher A. Beck, Patrick Bolger, Katherine F. Callahan, Grace F. Crotty, David Klements, Melissa Kostrzebski, Gearoid Michael McMahon, Lindsay Pothier, Sushrut S. Waikar, Anthony Lang, Tiago Mestre
Summary: In this randomized clinical trial, treatment with oral inosine for up to 2 years did not slow the progression of Parkinson disease in early stage patients. The study found that there was no significant difference in clinical disease progression between the inosine group and the placebo group.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Qiuyang Yu, Zhengyi Sun, Ying Wang, Xue Du, Jing Huang, Liying Wang
Summary: Hyperuricemia (HUA) leads to chronic inflammation and affects immune cells. While the association between HUA and monocytes and neutrophils has been extensively studied, research on HUA and lymphocytes is still limited. This study analyzed the correlation between serum uric acid (SUA) levels and immune cells in healthy participants and individuals with HUA, and investigated the relationship between SUA levels and cytokine levels. The results suggest that HUA is associated with elevated peripheral CD4(+) T cells and a Th2-dominant immune status.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Meng-Ko Tsai, Kuang-Chen Hung, Chun-Cheng Liao, Lung-Fa Pan, Chia-Lien Hung, Deng-Ho Yang
Summary: This study found that low testosterone levels in men may be associated with an increased risk of hyperuricemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Hongtao Chang, Benqiao Wang, Yue Shi, Ruixia Zhu
Summary: This study aimed to evaluate the correlation between urate levels or gout and the risk for Parkinson's disease (PD). The analysis showed that high serum urate levels were associated with a decreased risk for PD, while gout was not closely correlated with the risk for PD. Subgroup analysis by sex revealed a neuroprotective effect of high urate levels against PD among both females and males.
NPJ PARKINSONS DISEASE
(2022)
Article
Pharmacology & Pharmacy
Haochen Guan, Huagang Lin, Xiaojun Wang, Ying Xu, Yuqi Zheng, Xun Zhou, Xuehong Diao, Zhibin Ye, Jing Xiao
Summary: This study found that autophagy plays a key role in renal tubular injury and abnormal urate reabsorption induced by hyperuricaemia. Inhibiting autophagy can alleviate NKA impairment-mediated mitochondrial dysfunction and abnormal urate reabsorption, which may be a promising treatment for hyperuricaemia.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hang Zeng, Chenxi Tang, Bingru Lin, Mengli Yu, Xinyu Wang, Jinghua Wang, Shenghui Chen, Chaohui Yu
Summary: This study found a clinical association between GLUT9 polymorphism and MAFLD, and hepatic-specific knockout of Glut9 can decrease intrahepatic UA levels and ameliorate diet-induced MAFLD in mice.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Biophysics
Insu Kim, Young Im Kim, Sang Won Lee, Hyo Gi Jung, Gyudo Lee, Dae Sung Yoon
Summary: The study found that the uric acid transporter 1 (URAT1) abundant in kidney cell membranes can be utilized to develop a biosensor capable of selectively detecting uric acid.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Biochemistry & Molecular Biology
Wei-Zheng Zhang
Summary: Gout is a multifactorial metabolic disease where the role of hyperuricemia in its development is not solely definitive. Understanding the intricate role of serum uric acid (SUA) in gout pathogenesis is crucial for advancing clinical and pharmaceutical approaches towards a cure for the disease.
Article
Agriculture, Multidisciplinary
Bendong Yang, Meiling Xin, Shufei Liang, Yuhong Huang, Jingda Li, Chao Wang, Chao Liu, Xinhua Song, Jinyue Sun, Wenlong Sun
Summary: Naringenin reduces hyperuricemia and renal inflammation by promoting uric acid excretion and attenuating the release of inflammatory cytokines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Matthias B. Moor, Suresh K. Ramakrishnan, Finola Legrand, Matthias Bachtler, Robert Koesters, Nancy E. Hynes, Andreas Pasch, Olivier Bonny
Article
Respiratory System
Cecile Daccord, Jean-Marc Good, Marie-Anne Morren, Olivier Bonny, Daniel Hohl, Romain Lazor
EUROPEAN RESPIRATORY REVIEW
(2020)
Article
Transplantation
Dusan Harmacek, Anne Blanchard, Gregoire Wuerzner, Marc Maillard, Xavier Jeunemaitre, Michel Azizi, Olivier Bonny
Summary: During a high-Na/low-K diet, amiloride exhibits a strong acute hypocalciuric effect, most likely mediated by increased proximal tubular calcium reabsorption.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Education & Educational Research
Yara Barrense-Dias, Lorraine Chok, Sophie Stadelmann, Andre Berchtold, Joan-Carles Suris
Summary: There is a gap in the literature regarding data on sexting among youth under the age of 16, and this study aims to determine the prevalence rate and characteristics of sending sexually related images among middle-school teens. The study found that sending was associated with older age, low academic performance, cyberbullying victimization, and reception of unsolicited sexually related images. Education and health professionals should discuss this issue from an early age.
JOURNAL OF SCHOOL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Joan-Cartes Suris, Sophie Stadelmann, Diane Auderset, Yara Barrense-Dias
Summary: The research aimed to determine the prevalence and characteristics of youths engaging in transactional sex in Switzerland. It found that some youths who engaged in transactional sex were more likely to be males, have poor mental health, have multiple sexual partners, and experience other adverse factors. Professionals working with youth in Switzerland should include questions about transactional sex in their sexual assessments. Additionally, sexual education and prevention campaigns should address this phenomenon.
Letter
Urology & Nephrology
Dusan Harmacek, Menno Pruijm, Michel Burnier, Marie-Eve Muller, Arlene Ghajarzadeh-Wurzner, Olivier Bonny, Anne Zanchi
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yara Barrense-Dias, Sophie Stadelmann, Joan-Carles Suris, Christina Akre
Summary: This qualitative study explores the experiences of adolescent and young adult females who have gone to a pharmacy to obtain emergency contraception (EC). The study finds that the most difficult moment in the process for participants was making the request at the counter, and opinions were divided regarding being escorted to a private back room. Lack of information and knowledge about the dispensation process resulted in negative experiences for some participants. Several participants also reported perceived or received moral judgements from pharmacists.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2022)
Article
Multidisciplinary Sciences
Daniela Cabuzu, Suresh K. Ramakrishnan, Matthias B. Moor, Dusan Harmacek, Muriel Auberson, Fanny Durussel, Olivier Bonny
Summary: This study validated the increased expression of Ecrg4 gene in hypercalciuric mouse models and described its expression along the nephron. By conducting experiments on Ecrg4 knockout mice, it was found that Ecrg4 may modulate renal crystallization and provide new therapeutic possibilities against calcium oxalate nephropathy.
Article
Pediatrics
J. -C. Suris, S. Stadelmann, L. Chok, Y. Barrense-Dias
Summary: The aim of the study was to describe the differences between users and non-users of social networks controlling for explanatory factors. The results showed that inactive participants were more likely to be males, younger, to live in an intact family, and to assess their screen time as below average, and less likely to practice extracurricular sport, to spend ≥4 h of screen time per day, to be around their smartphone at all times, to have parental rules about Internet content, or to discuss Internet use with parents.
ARCHIVES DE PEDIATRIE
(2023)
Review
Urology & Nephrology
Constance Legay, Tropoja Krasniqi, Alice Bourdet, Olivier Bonny, Murielle Bochud
Summary: This scoping review examines the methods used to study the diet of adult kidney stone formers. The study found that food frequency questionnaires and other questionnaires were the most commonly used methods, while new technologies were rarely used. Assessing long-term dietary intake remains a challenge.
JOURNAL OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Maelle Mora-Monteros, Yara Barrense-Dias, Diane Auderset, Sophie Stadelmann, Nicolas Senn, Joan-Carles Suris
Summary: The study found that most youths are not well-informed about discussing transition to adult healthcare with their pediatrician. However, those who have had this discussion are more likely to have a primary care provider. Girls with a below-average socioeconomic status and boys with advanced puberty onset are more likely to have discussed transition.
SWISS MEDICAL WEEKLY
(2021)
Article
Public, Environmental & Occupational Health
Marion Meuwly, Joan-Carles Suris, Diane Auderset, Sophie Stadelmann, Yara Barrense-Dias
Summary: This study found that about 1 in 20 young adults are virgins, who are more likely to be male, have poorer health, and lower social satisfaction. The main reasons for remaining virgin reveal gender-stereotyped responses.
Article
Psychology, Clinical
Marion Meuwly, Diane Auderset, Sophie Stadelmann, Joan-Carles Suris, Yara Barrense-Dias
Summary: The study shows that anal intercourse (AI) among heterosexuals is a widespread practice, with main motivations being curiosity and love. Participants engaging in AI are more likely to have intercourse while intoxicated, experience a younger age at first sexual experience, not use condoms during last intercourse, and report a history of sexual transmitted infections.
JOURNAL OF SEX RESEARCH
(2021)
Article
Physiology
Matthias B. Moor, Olivier Bonny
PHYSIOLOGICAL REPORTS
(2020)