Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

Sleep and circadian rhythms in α‐synucleinopathies—Perspectives for disease modification

(2023) Dieter Kunz et al.   Acta Physiologica

Circadian control of heparan sulfate levels times phagocytosis of amyloid beta aggregates

(2022) Gretchen T. Clark et al.   PLoS Genetics

Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics

(2022) Kari R. Hoyt et al.   Molecular Neurodegeneration

Foundations of circadian medicine

(2022) Achim Kramer et al.   PLOS BIOLOGY

Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases

(2022) Jun Y. Oh et al.   JAMA Neurology

Sleep function: an evolutionary perspective

(2022) Jerome M Siegel   LANCET NEUROLOGY

Desynchronizing the sleep­­–wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period

(2022) Wei Wang et al.   Nature Protocols

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update

(2021) Karim Fifel et al.   Frontiers in Neuroscience

Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease

(2021) Md. Sahab Uddin et al.   NEUROCHEMICAL RESEARCH

Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults

(2021) Philip S. Insel et al.   JAMA Network Open

Ambient bright lighting in the morning improves sleep disturbances of older adults with dementia

(2021) Chuen-Ru Liu et al.   SLEEP MEDICINE

Circadian rhythm disruption and mental health

(2020) William H. Walker et al.   Translational Psychiatry

Bright light improves sleep in patients with Parkinson’s disease: possible role of circadian restoration

(2020) Takuyuki Endo et al.   Scientific Reports

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease

(2020) Müge Yalçin et al.   Cancers

Coupled network of the circadian clocks: a driving force of rhythmic physiology

(2020) Anna‐Marie Finger et al.   FEBS LETTERS

The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration

(2020) Brian V. Lananna et al.   NEUROBIOLOGY OF DISEASE

Mammalian circadian systems: Organization and modern life challenges

(2020) Anna‐Marie Finger et al.   Acta Physiologica

Epigenetic Regulation of BMAL1 with Sleep Disturbances and Alzheimer’s Disease

(2020) Bethany Hulme et al.   JOURNAL OF ALZHEIMERS DISEASE

It's complicated: The relationship between sleep and Alzheimer's disease in humans

(2020) Brendan P. Lucey   NEUROBIOLOGY OF DISEASE

Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease

(2020) Yuanming Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating’s Effects on Human Health

(2020) Réda Adafer et al.   Nutrients

The arrival of circadian medicine

(2019) Satchidananda Panda   Nature Reviews Endocrinology

Association between circadian rhythms and neurodegenerative diseases

(2019) Yue Leng et al.   LANCET NEUROLOGY

Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes

(2019) Robbert Havekes et al.   CELLULAR SIGNALLING

Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors

(2019) Chanung Wang et al.   NEUROPSYCHOPHARMACOLOGY

Dosing time matters

(2019) Marc D. Ruben et al.   SCIENCE

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

(2019) Junjun Ni et al.   Journal of Neuroinflammation

Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia

(2018) Claire Guissart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

(2018) Erik S. Musiek et al.   JAMA Neurology

Light Therapy and Alzheimer's Disease and Related Dementia: Past, Present, and Future

(2018) Nicholas Hanford et al.   JOURNAL OF ALZHEIMERS DISEASE

Circadian Misalignment and Sleep Disruption in Mild Cognitive Impairment

(2018) Sharon L. Naismith et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin ameliorates Aβ1-42 -induced Alzheimer's cognitive deficits in mouse model

(2017) Yu-Hang Gong et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Macromolecular Assemblies of the Mammalian Circadian Clock

(2017) Rajindra P. Aryal et al.   MOLECULAR CELL

Neural Circuitry of Wakefulness and Sleep

(2017) Thomas E. Scammell et al.   NEURON

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

(2017) Lama M. Chahine et al.   SLEEP MEDICINE REVIEWS

Timed Light Therapy for Sleep and Daytime Sleepiness Associated With Parkinson Disease

(2017) Aleksandar Videnovic et al.   JAMA Neurology

Amyloid-β–Induced Changes in Molecular Clock Properties and Cellular Bioenergetics

(2017) Karen Schmitt et al.   Frontiers in Neuroscience

The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish

(2016) Guodong Huang et al.   Autophagy

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

(2016) Qing-Fei Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

The two-process model of sleep regulation: a reappraisal

(2016) Alexander A. Borbély et al.   JOURNAL OF SLEEP RESEARCH

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Mammalian Period represses and de-represses transcription by displacing CLOCK–BMAL1 from promoters in a Cryptochrome-dependent manner

(2016) Yi-Ying Chiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian time signatures of fitness and disease

(2016) Joseph Bass et al.   SCIENCE

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

(2015) Hyundong Song et al.   Molecular Neurodegeneration

Circadian rhythms – from genes to physiology and disease

(2015) T Bollinger et al.   SWISS MEDICAL WEEKLY

Interactive Features of Proteins Composing Eukaryotic Circadian Clocks

(2014) Brian R. Crane et al.   Annual Review of Biochemistry

Metabolic and Nontranscriptional Circadian Clocks: Eukaryotes

(2014) Akhilesh B. Reddy et al.   Annual Review of Biochemistry

Shift work and diabetes – A systematic review

(2014) Anders Knutsson et al.   CHRONOBIOLOGY INTERNATIONAL

Circadian Clock Proteins and Immunity

(2014) Anne M. Curtis et al.   IMMUNITY

Motivational activation: a unifying hypothesis of orexin/hypocretin function

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

'The clocks that time us'—circadian rhythms in neurodegenerative disorders

(2014) Aleksandar Videnovic et al.   Nature Reviews Neurology

Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

(2014) Brendan P. Lucey et al.   NEUROBIOLOGY OF AGING

Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease

(2014) Claudio Liguori et al.   JAMA Neurology

Circadian clocks and neurodegenerative diseases: time to aggregate?

(2013) Michael H Hastings et al.   CURRENT OPINION IN NEUROBIOLOGY

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic immune system alterations in early stages of Alzheimer's disease

(2013) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Sleep and Alzheimer disease pathology—a bidirectional relationship

(2013) Yo-El S. Ju et al.   Nature Reviews Neurology

Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later

(2013) C. M. Roe et al.   NEUROLOGY

A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity

(2013) S. R. Morairty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons

(2013) Andrew S. P. Lim et al.   SLEEP

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

(2013) Yoshinori Hayashi et al.   Scientific Reports

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Rev-erb  and Rev-erb  coordinately protect the circadian clock and normal metabolic function

(2012) A. Bugge et al.   GENES & DEVELOPMENT

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

(2012) J. H. Roh et al.   Science Translational Medicine

Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women

(2011) Gregory J. Tranah et al.   ANNALS OF NEUROLOGY

Clock genes and sleep

(2011) Dominic Landgraf et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities

(2008) Rixt F. Riemersma-van der Lek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Melatonin and Bright-Light Treatment for Rest–Activity Disruption in Institutionalized Patients with Alzheimer's Disease

(2008) Glenna A. Dowling et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

The genetics of mammalian circadian order and disorder: implications for physiology and disease

(2008) Joseph S. Takahashi et al.   NATURE REVIEWS GENETICS