Retinal pathological features and proteome signatures of Alzheimer’s disease

Dysfunctional microglia and tau pathology in Alzheimer’s disease

(2022) Gunel Ayyubova   REVIEWS IN THE NEUROSCIENCES

Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia

(2022) Haoshen Shi et al.   Acta Neuropathologica Communications

Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina

(2022) Qinyuan Alis Xu et al.   Acta Neuropathologica Communications

Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies

(2022) Frederique J. Hart de Ruyter et al.   ACTA NEUROPATHOLOGICA

Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze

(2021) Jean-Philippe Vit et al.   Scientific Reports

Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy

(2021) Asgeir Kobro-Flatmoen et al.   AGEING RESEARCH REVIEWS

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research

(2021) Christina M. Moloney et al.   Alzheimers & Dementia

Association of Retinal Changes With Alzheimer Disease Neuroimaging Biomarkers in Cognitively Normal Individuals

(2021) Min Soo Byun et al.   JAMA Ophthalmology

Retinal Amyloid Imaging for Screening Alzheimer’s Disease

(2021) Koh Tadokoro et al.   JOURNAL OF ALZHEIMERS DISEASE

Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus

(2021) Brianne M. Bettcher et al.   Nature Reviews Neurology

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

(2021) Alexandra Grubman et al.   Nature Communications

Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging

(2021) Joseph R. Winer et al.   JAMA Neurology

Retinal Vasculopathy in Alzheimer’s Disease

(2021) Haoshen Shi et al.   Frontiers in Neuroscience

ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina

(2021) Kevin J. Cao et al.   Translational Vision Science & Technology

Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study

(2021) Oana M. Dumitrascu et al.   Cells

Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina

(2020) Haoshen Shi et al.   ACTA NEUROPATHOLOGICA

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

(2020) Bing Bai et al.   NEURON

Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses

(2020) Songlin Li et al.   Frontiers in Immunology

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline

(2020) Samuel Asanad et al.   PLoS One

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals

(2020) Reisa A. Sperling et al.   JAMA Neurology

Age-Specific Retinal and Cerebral Immunodetection of Amyloid-β Plaques and Oligomers in a Rodent Model of Alzheimer’s Disease

(2020) Umma Habiba et al.   JOURNAL OF ALZHEIMERS DISEASE

Quantitative proteomic analysis of the frontal cortex in Alzheimer’s disease

(2020) Gajanan Sathe et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer’s Eye

(2020) Sieun Lee et al.   Frontiers in Neuroscience

Retinal imaging in Alzheimer's and neurodegenerative diseases

(2020) Peter J. Snyder et al.   Alzheimers & Dementia

Inflammation in Alzheimer’s Disease: Do Sex and APOE Matter?

(2020) Paula Duarte-Guterman et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Retinopathy: Seeing Disease in the Eyes

(2020) Nazanin Mirzaei et al.   Frontiers in Neuroscience

Predicting Thioflavin Fluorescence of Retinal Amyloid Deposits Associated With Alzheimer's Disease from Their Polarimetric Properties

(2020) Yunyi Qiu et al.   Translational Vision Science & Technology

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

(2020) Lenora Higginbotham et al.   Science Advances

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms

(2020) Grayson W. Armstrong et al.   JAMA Ophthalmology

S100 Proteins in Alzheimer’s Disease

(2019) Joana S. Cristóvão et al.   Frontiers in Neuroscience

Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis

(2019) Alfonso Grimaldi et al.   Frontiers in Neuroscience

In Vivo Assessment of Retinal Biomarkers by Hyperspectral Imaging: Early Detection of Alzheimer’s Disease

(2019) Swati S. More et al.   ACS Chemical Neuroscience

Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers

(2019) Chiara Scopa et al.   CELL DEATH AND DIFFERENTIATION

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

(2019) Xavier Hadoux et al.   Nature Communications

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease

(2019) Maya Koronyo-Hamaoui et al.   BRAIN

Levels of Retinal Amyloid-β Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-β in Neuropathologically Evaluated Individuals

(2019) Nina Schultz et al.   JOURNAL OF ALZHEIMERS DISEASE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

(2018) Minghui Wang et al.   Scientific Data

Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set

(2018) Lilah Besser et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings

(2018) Bliss Elizabeth O’Bryhim et al.   JAMA Ophthalmology

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer’s disease retinas

(2018) Jurre den Haan et al.   Acta Neuropathologica Communications

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease

(2017) S.Mojtaba Golzan et al.   Alzheimers Research & Therapy

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Optical Coherence Tomography in Alzheimer’s Disease and Other Neurodegenerative Diseases

(2017) Jonah Doustar et al.   Frontiers in Neurology

Ocular indicators of Alzheimer’s: exploring disease in the retina

(2016) Nadav J. Hart et al.   ACTA NEUROPATHOLOGICA

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Reconnecting Eye to Brain

(2016) Michael C. Crair et al.   JOURNAL OF NEUROSCIENCE

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

Glia–neuron interactions in the mammalian retina

(2016) Elena Vecino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

(2015) Bruno Dubois et al.   Alzheimers & Dementia

Melanopsin retinal ganglion cell loss in Alzheimer disease

(2015) Chiara La Morgia et al.   ANNALS OF NEUROLOGY

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

(2015) Rahul Arvo Jonas et al.   PLoS One

Optical Coherence Tomography in Alzheimer’s Disease: A Meta-Analysis

(2015) Gianluca Coppola et al.   PLoS One

Connecting the Retina to the Brain

(2014) Lynda Erskine et al.   ASN Neuro

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

(2014) Giovanni Meli et al.   Nature Communications

Detection of Retinal Nerve Fiber Layer Defects in Alzheimer’s Disease Using SD-OCT

(2014) Robert Kromer et al.   Frontiers in Psychiatry

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

(2013) Willem Kamphuis et al.   NEUROBIOLOGY OF AGING

Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice

(2013) Christian Schön et al.   PLoS One

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Retinal Nerve Fiber Layer Thickness in Patients With Alzheimer Disease

(2012) Serkan Kirbas et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

In VivoMolecular Imaging in Retinal Disease

(2012) Fang Xie et al.   Journal of Ophthalmology

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

The CERAD Neuropsychologic Battery Total Score and the Progression of Alzheimer Disease

(2010) Heidi C. Rossetti et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Direct in Vivo Intracellular Selection of Conformation-sensitive Antibody Domains Targeting Alzheimer's Amyloid-β Oligomers

(2009) Giovanni Meli et al.   JOURNAL OF MOLECULAR BIOLOGY

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE