The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
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Title
The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
Authors
Keywords
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Journal
Cellular & Molecular Immunology
Volume 12, Issue 6, Pages 656-668
Publisher
Springer Nature
Online
2015-04-13
DOI
10.1038/cmi.2015.28
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Note: Only part of the references are listed.- Induction of ATM/ATR pathway combined with Vγ2Vδ2 T cells enhances cytotoxicity of ovarian cancer cells
- (2014) Jingwei Lu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
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- (2014) M. V. Maus et al. BLOOD
- Endothelial cell protein C receptor: a multiliganded and multifunctional receptor
- (2014) L. V. Mohan Rao et al. BLOOD
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- (2014) Zheng Xiang et al. CANCER CELL
- Novel Bispecific Antibodies Increase T-Cell Cytotoxicity against Pancreatic Cancer Cells
- (2014) H.-H. Oberg et al. CANCER RESEARCH
- Cytomegalovirus drives Vδ2negγδ T cell inflation in many healthy virus carriers with increasing age
- (2014) A. Alejenef et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies
- (2014) D. C. Deniger et al. CLINICAL CANCER RESEARCH
- Neuroblastoma Killing Properties of V 2 and V 2-Negative T Cells Following Expansion by Artificial Antigen-Presenting Cells
- (2014) J. P. H. Fisher et al. CLINICAL CANCER RESEARCH
- Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6
- (2014) Felipe Riaño et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- CD8αα + Innate-Type Lymphocytes in the Intestinal Epithelium Mediate Mucosal Immunity
- (2014) Luc Van Kaer et al. IMMUNITY
- The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian α-Linked Glycosylceramides
- (2014) Lisa Kain et al. IMMUNITY
- The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells
- (2014) Andrew Sandstrom et al. IMMUNITY
- Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos)
- (2014) Mohindar M. Karunakaran et al. IMMUNOGENETICS
- Phosphoantigens and butyrophilin 3A1 induce similar intracellular activation signaling in human TCRVγ9+ γδ T lymphocytes
- (2014) Emilie Decaup et al. IMMUNOLOGY LETTERS
- The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification
- (2014) Francis Coffey et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The molecular bases of δ/αβ T cell–mediated antigen recognition
- (2014) Daniel G. Pellicci et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A novel self-lipid antigen targets human T cells against CD1c+leukemias
- (2014) Marco Lepore et al. JOURNAL OF EXPERIMENTAL MEDICINE
- T Cell Receptor Transfer to T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo
- (2014) L. T. van der Veken et al. JOURNAL OF IMMUNOLOGY
- Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells
- (2014) Martin Wilhelm et al. Journal of Translational Medicine
- Enforcement of -lineage commitment by the pre-T-cell receptor in precursors with weak -TCR signals
- (2014) P. Zarin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing
- (2014) Elaine P. Dopfer et al. Cell Reports
- Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer
- (2014) Ikuo Wada et al. Cancer Medicine
- Natural killer T cell strategies to combat Epstein–Barr virus infection
- (2014) John J Priatel et al. OncoImmunology
- A novel antibody-like TCRγδ-Ig fusion protein exhibits antitumor activity against human ovarian carcinoma
- (2013) Jing Zheng et al. CANCER LETTERS
- Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid
- (2013) Atif S. M. Idrees et al. CANCER SCIENCE
- Neutrophil uptake of nitrogen-bisphosphonates leads to the suppression of human peripheral blood γδ T cells
- (2013) Shirin Kalyan et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain and the common γ-chain
- (2013) Takamichi Izumi et al. CYTOTHERAPY
- Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells
- (2013) Adrienne M. Luoma et al. IMMUNITY
- Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma
- (2013) Jiuwei Cui et al. INTERNATIONAL JOURNAL OF CANCER
- Human Vγ2Vδ2 T cells limit breast cancer growth by modulating cell survival-, apoptosis-related molecules and microenvironment in tumors
- (2013) Reeva Aggarwal et al. INTERNATIONAL JOURNAL OF CANCER
- Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) Pathway Initiated by T Cell Antigen Receptor (TCRγδ) Activation Is Required to Overcome Inhibition by Ubiquitin Ligase Cbl-b during γδT Cell Cytotoxicity
- (2013) Shanshan Yin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells
- (2013) B. A. Mangan et al. JOURNAL OF IMMUNOLOGY
- Essential Requirements of Zoledronate-Induced Cytokine and T Cell Proliferative Responses
- (2013) O. Nussbaumer et al. JOURNAL OF IMMUNOLOGY
- Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human V 2V 2 T Cells
- (2013) H. Wang et al. JOURNAL OF IMMUNOLOGY
- γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia
- (2013) W Scheper et al. LEUKEMIA
- CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis
- (2013) Agnieszka Bojarska-Junak et al. LEUKEMIA RESEARCH
- Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor
- (2013) Drew C Deniger et al. MOLECULAR THERAPY
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- (2013) Jia Zhu et al. NATURE
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- (2013) Masayuki Hirano et al. NATURE
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- (2013) Maria Themeli et al. NATURE BIOTECHNOLOGY
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- (2013) Cormac Sheridan NATURE BIOTECHNOLOGY
- CD1d-lipid antigen recognition by the γδ TCR
- (2013) Adam P Uldrich et al. NATURE IMMUNOLOGY
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- (2013) Stefano Vavassori et al. NATURE IMMUNOLOGY
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- (2012) M. Coscia et al. BLOOD
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- (2012) C. Harly et al. BLOOD
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- (2012) Jian Zheng et al. Cellular & Molecular Immunology
- In Vivo Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Trigger V 9V 2 T-cell Antitumor Cytotoxicity through ICAM-1 Engagement
- (2012) I. Benzaid et al. CLINICAL CANCER RESEARCH
- The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR
- (2012) Li Bai et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies
- (2012) Milos Aleksic et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response
- (2012) Hassnae Afrache et al. IMMUNOGENETICS
- The molecular determinants of CD8 co-receptor function
- (2012) David K. Cole et al. IMMUNOLOGY
- Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines
- (2012) Silvina B. Nadin et al. INTERNATIONAL JOURNAL OF HYPERTHERMIA
- The Molecular Basis for Modulation of Human Vγ9Vδ2 T Cell Responses by CD277/Butyrophilin-3 (BTN3A)-specific Antibodies
- (2012) Aparna Palakodeti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ectopically Expressed Human Tumor Biomarker MutS Homologue 2 Is a Novel Endogenous Ligand That Is Recognized by Human γδ T Cells to Induce Innate Anti-tumor/Virus Immunity
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- (2012) Chen Mo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2012) Joanne L Welton et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy
- (2012) Volker Kunzmann et al. JOURNAL OF IMMUNOTHERAPY
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- (2012) Alexander Hoh et al. LIVER INTERNATIONAL
- Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor
- (2012) Carrie R Willcox et al. NATURE IMMUNOLOGY
- Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
- (2012) Kavitha Narayan et al. NATURE IMMUNOLOGY
- Monoclonal TCR-redirected tumor cell killing
- (2012) Nathaniel Liddy et al. NATURE MEDICINE
- Targeting tumor cell metabolism with statins
- (2012) J W Clendening et al. ONCOGENE
- MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection
- (2012) François Van Laethem et al. TRENDS IN IMMUNOLOGY
- Human MHC Class I-restricted high avidity CD4+T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo
- (2012) Shao-An Xue et al. OncoImmunology
- Redirecting T cells against cancer cells by transfer of a broadly tumor-reactive T-cell receptor
- (2011) V. Marcu-Malina et al. BLOOD
- Antibody-dependent anti-cytomegalovirus activity of human T cells expressing CD16 (Fc RIIIa)
- (2011) L. Couzi et al. BLOOD
- Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours
- (2011) A J Nicol et al. BRITISH JOURNAL OF CANCER
- Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma
- (2011) Hirohito Kobayashi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma
- (2011) Joshua M. Lang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CDR3δ -grafted γ9δ2T cells mediate effective antitumor reactivity
- (2011) Hui Zhao et al. Cellular & Molecular Immunology
- Anti-γδ TCR antibody-expanded γδ T cells: a better choice for the adoptive immunotherapy of lymphoid malignancies
- (2011) Jianhua Zhou et al. Cellular & Molecular Immunology
- Coreceptor gene imprinting governs thymocyte lineage fate
- (2011) Stanley Adoro et al. EMBO JOURNAL
- Indirect Stimulation of Human Vγ2Vδ2 T Cells through Alterations in Isoprenoid Metabolism
- (2011) Hong Wang et al. JOURNAL OF IMMUNOLOGY
- Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial
- (2011) Michael Gnant et al. LANCET ONCOLOGY
- Skint-1 is a highly specific, unique selecting component for epidermal T cells
- (2011) S. D. Barbee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of a T-cell receptor specific for the human MHC class I homolog MICA
- (2011) B. Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adoptive immunotherapy of lung cancer with immobilized anti-TCRγδ antibody-expanded human γδ T Cells in peripheral blood
- (2010) Ning Kang et al. CANCER BIOLOGY & THERAPY
- Therapeutic Targeting of the DNA Mismatch Repair Pathway
- (2010) S. A. Martin et al. CLINICAL CANCER RESEARCH
- Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors
- (2010) Atsutaka Noguchi et al. CYTOTHERAPY
- F1-Adenosine Triphosphatase Displays Properties Characteristic of an Antigen Presentation Molecule for V 9V 2 T Cells
- (2010) J. Mookerjee-Basu et al. JOURNAL OF IMMUNOLOGY
- First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial
- (2010) Gareth J Morgan et al. LANCET
- Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
- (2010) Gavin M Bendle et al. NATURE MEDICINE
- Mixed T cell receptor dimers harbor potentially harmful neoreactivity
- (2010) M. M. van Loenen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dysregulation of the mevalonate pathway promotes transformation
- (2010) J. W. Clendening et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR and NKG2D
- (2009) Y. Kong et al. BLOOD
- γδ T cells develop independently of Aire
- (2009) Heli Tuovinen et al. CELLULAR IMMUNOLOGY
- Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes
- (2009) A Hiasa et al. GENE THERAPY
- Cytomegalovirus-Induced T Cells Associate with Reduced Cancer Risk after Kidney Transplantation
- (2009) L. Couzi et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma
- (2008) Jaafar Bennouna et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Identification of Human T Cell Receptor γδ-recognized Epitopes/Proteins via CDR3δ Peptide-based Immunobiochemical Strategy
- (2008) Hui Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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