New prospects on the NKG2D/NKG2DL system for oncology

Effect of NKG2D ligand expression on host immune responses

(2015) Marine Champsaur et al.   IMMUNOLOGICAL REVIEWS

Valproic Acid Upregulates NKG2D Ligand Expression through an ERK-dependent Mechanism and Potentially Enhances NK Cell-mediated Lysis of Myeloma

(2015) Xiaosong Wu et al.   NEOPLASIA

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

(2013) N. Fiegler et al.   BLOOD

Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire

(2013) S. Sheppard et al.   BLOOD

NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors

(2013) Paul Spear et al.   IMMUNOLOGY AND CELL BIOLOGY

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection

(2013) Joachim Koch et al.   TRENDS IN IMMUNOLOGY

NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

(2012) Esther M de Kruijf et al.   BMC CANCER

MiR-10b Downregulates the Stress-Induced Cell Surface Molecule MICB, a Critical Ligand for Cancer Cell Recognition by Natural Killer Cells

(2012) P. Tsukerman et al.   CANCER RESEARCH

Suppressing T cell motility induced by anti–CTLA-4 monotherapy improves antitumor effects

(2012) Maria Grazia Ruocco et al.   JOURNAL OF CLINICAL INVESTIGATION

RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry

(2012) Heiyoun Jung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Tumor-Targeting Antibodies Enhance NKG2D-Mediated NK Cell Cytotoxicity by Stabilizing NK Cell-Tumor Cell Interactions

(2012) J. Deguine et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Analysis of NKG2D Ligand Expression and Release in Leukemia: Implications for NKG2D-Mediated NK Cell Responses

(2012) J. Hilpert et al.   JOURNAL OF IMMUNOLOGY

Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection

(2012) Manfred Lehner et al.   PLoS One

Human NKG2D-ligands: cell biology strategies to ensure immune recognition

(2012) Lola Fernández-Messina et al.   Frontiers in Immunology

Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2

(2011) S. Textor et al.   CANCER RESEARCH

Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

(2011) A. Heinemann et al.   CANCER RESEARCH

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2

(2011) Hai Li et al.   CELL CYCLE

Regulation of immune cell function and differentiation by the NKG2D receptor

(2011) Biljana Zafirova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction

(2011) Maya Caroline André et al.   INTERNATIONAL JOURNAL OF CANCER

Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence

(2011) Hiroteru Kamimura et al.   JOURNAL OF HEPATOLOGY

Modulation of NKG2D-ligand Cell Surface Expression Enhances Immune Cell Therapy of Cancer

(2011) Baocheng Huang et al.   JOURNAL OF IMMUNOTHERAPY

Mechanisms of Tumor and Viral Immune Escape from Natural Killer Cell-Mediated Surveillance

(2011) Ariane Groth et al.   Journal of Innate Immunity

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression

(2011) Lucas E. Rossi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity

(2011) C Kellner et al.   LEUKEMIA

Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

(2011) A. C. Benitez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-2-activated haploidentical NK cells restore NKG2D-mediated NK-cell cytotoxicity in neuroblastoma patients by scavenging of plasma MICA

(2010) Stephan Kloess et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential Clinical Significance of Individual NKG2D Ligands in Melanoma: Soluble ULBP2 as an Indicator of Poor Prognosis Superior to S100B

(2009) A. Paschen et al.   CLINICAL CANCER RESEARCH

Obstructing Shedding of the Immunostimulatory MHC Class I Chain-Related Gene B Prevents Tumor Formation

(2009) J. D. Wu et al.   CLINICAL CANCER RESEARCH

Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice

(2009) Biljana Zafirova et al.   IMMUNITY

An integrated view of the regulation of NKG2D ligands

(2009) Noam Stern-Ginossar et al.   IMMUNOLOGY

Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC

(2009) Atsushi Inagaki et al.   INTERNATIONAL JOURNAL OF CANCER

HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer

(2009) A López-Soto et al.   ONCOGENE

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

(2008) A. Soriani et al.   BLOOD

Tumor-Associated MICA Is Shed by ADAM Proteases

(2008) I. Waldhauer et al.   CANCER RESEARCH

Direct and Natural Killer Cell-Mediated Antitumor Effects of Low-Dose Bortezomib in Hepatocellular Carcinoma

(2008) S. Armeanu et al.   CLINICAL CANCER RESEARCH

Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?

(2008) Stipan Jonjić et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Soluble NKG2D ligands: prevalence, release, and functional impact

(2008) Helmut Rainer Salih   Frontiers in Bioscience-Landmark

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY

Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

(2008) Jessica Strid et al.   NATURE IMMUNOLOGY

NKG2D ligands in tumor immunity

(2008) N Nausch et al.   ONCOGENE

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE