Recent progress in ferroptosis: inducers and inhibitors

Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)

(2022) Hiromasa Yoshioka et al.   ACS Chemical Biology

p53 in ferroptosis regulation: the new weapon for the old guardian

(2022) Yanqing Liu et al.   CELL DEATH AND DIFFERENTIATION

Small Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53

(2022) Junhui Li et al.   MOLECULAR CANCER THERAPEUTICS

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

(2022) Hai-Liang Zhang et al.   NATURE CELL BIOLOGY

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion

(2022) Anne von Mässenhausen et al.   Science Advances

Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity

(2022) Lu Yao et al.   ACS Nano

Nano-enabled photosynthesis in tumours to activate lipid peroxidation for overcoming cancer resistances

(2022) Jun Jiang et al.   BIOMATERIALS

Non-coding RNAs and ferroptosis: potential implications for cancer therapy

(2022) Amar Balihodzic et al.   CELL DEATH AND DIFFERENTIATION

Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA

(2022) Ying Zhang et al.   CELL DEATH AND DIFFERENTIATION

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

(2022) Abdel Ali Belaidi et al.   MOLECULAR PSYCHIATRY

Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

(2022) Mingming Wu et al.   Nature Communications

Metabolic Intervention Nanoparticles for Triple‐Negative Breast Cancer Therapy via Overcoming FSP1‐Mediated Ferroptosis Resistance

(2022) Jie Yang et al.   Advanced Healthcare Materials

NFE2L1-mediated proteasome function protects from ferroptosis

(2022) Stefan Kotschi et al.   Molecular Metabolism

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

(2022) Brent R. Stockwell   CELL

Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma

(2022) Fei Yao et al.   CELL DEATH AND DIFFERENTIATION

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

(2022) Eikan Mishima et al.   NATURE

Focus on ferroptosis regulation: Exploring novel mechanisms and applications of ferroptosis regulator

(2022) Tian-Liang Ma et al.   LIFE SCIENCES

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

miR-129-5p inhibits clear cell renal cell carcinoma cell proliferation, migration and invasion by targeting SPN

(2021) Bin Gao et al.   Cancer Cell International

Long non-coding RNA NEAT1 regulates ferroptosis sensitivity in non-small-cell lung cancer

(2021) Hongxia Wu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells

(2021) Hironari Nishizawa et al.   Cell Death & Disease

Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

(2021) Priyanka S. Radadiya et al.   JCI Insight

Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

(2021) Rundi Song et al.   ADVANCED MATERIALS

Mitochondrial regulation of ferroptosis

(2021) Boyi Gan   JOURNAL OF CELL BIOLOGY

Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

(2021) Pengchong Li et al.   NATURE IMMUNOLOGY

Ferroptosis in the tumor microenvironment: perspectives for immunotherapy

(2021) Huanji Xu et al.   TRENDS IN MOLECULAR MEDICINE

GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis

(2021) Qian Hu et al.   Cell Death & Disease

A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics

(2021) Chenyao Wu et al.   Science Advances

Ultrasound‐Augmented Nanocatalytic Ferroptosis Reverses Chemotherapeutic Resistance and Induces Synergistic Tumor Nanotherapy

(2021) Yi Zheng et al.   ADVANCED FUNCTIONAL MATERIALS

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer

(2021) Wenjie Luo et al.   Cell Death & Disease

Proteostasis in thermogenesis and obesity

(2020) Alexander Bartelt et al.   BIOLOGICAL CHEMISTRY

Cobalt nanoparticles trigger ferroptosis‐like cell death (oxytosis) in neuronal cells: Potential implications for neurodegenerative disease

(2020) Govind Gupta et al.   FASEB JOURNAL

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

(2020) Haiyang Zhang et al.   Molecular Cancer

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer

(2020) Daiha Shin et al.   Redox Biology

High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)

(2020) Itsuki Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy

(2020) Qingqing Guan et al.   JOURNAL OF CONTROLLED RELEASE

“Iron free” zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis

(2020) Changping Zhang et al.   Cell Death & Disease

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma

(2020) Ji Feng et al.   ACTA PHARMACOLOGICA SINICA

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death

(2020) Shujuan Xu et al.   Nature Communications

Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes

(2020) Hao Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

(2020) Michelle Riegman et al.   NATURE CELL BIOLOGY

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

(2019) Eduardo P. Amaral et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Cell–cell contacts protect against t-BuOOH-induced cellular damage and ferroptosis in vitro

(2019) Christine Wenz et al.   ARCHIVES OF TOXICOLOGY

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Co-loading antioxidant N-acetylcysteine attenuates cytotoxicity of iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes

(2019) Yunli Shen et al.   International Journal of Nanomedicine

Fe2+/Fe3+ Ions Chelated with Ultrasmall Polydopamine Nanoparticles Induce Ferroptosis for Cancer Therapy

(2019) Lu Chen et al.   ACS Biomaterials-Science & Engineering

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

A new checkpoint against ferroptosis

(2019) Deguang Liang et al.   CELL RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9

(2018) Qi Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

Dkk1 involvement and its potential as a biomarker in pancreatic ductal adenocarcinoma

(2018) Eseosaserea Igbinigie et al.   CLINICA CHIMICA ACTA

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

(2018) Ziliang Dong et al.   NANO LETTERS

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

(2017) Weijun Ou et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation

(2017) Magdalena Skonieczna et al.   Medicinal Chemistry

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

The Complex Role of Apolipoprotein E in Alzheimer’s Disease: an Overview and Update

(2016) Laura Mahoney-Sanchez et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

(2015) Le Jiang et al.   CELL CYCLE

Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells

(2015) Katja Linher-Melville et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

New biological perspectives for the improvement of the efficacy of sorafenib in hepatocellular carcinoma

(2014) Antoine Galmiche et al.   CANCER LETTERS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Wnt/β-Catenin Pathway Cross-Talks with STAT3 Signaling to Regulate Survival of Retinal Pigment Epithelium Cells

(2012) Miryam A. Fragoso et al.   PLoS One

Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles

(2011) Mohd Imran Khan et al.   BIOMATERIALS

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress

(2010) Naqvi et al.   International Journal of Nanomedicine

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY