Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Ponceau S waste: Ponceau S staining for total protein normalization

(2019) Hannah Sander et al.   ANALYTICAL BIOCHEMISTRY

Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment for Urothelial Cancers in Rats and Dogs

(2019) Scott J Weir et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

(2019) Jung-Ah Kang et al.   Nature Communications

Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent

(2019) Hongxuan Feng et al.   Acta Pharmaceutica Sinica B

Effects of the antifungal agent ciclopirox in HPV‐positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis

(2019) Julia A. Braun et al.   INTERNATIONAL JOURNAL OF CANCER

Apoptosis and autophagy in polycystic kidney disease (PKD)

(2019) Kristen L. Nowak et al.   CELLULAR SIGNALLING

Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism

(2018) Yamei Sun et al.   JOURNAL OF VIROLOGY

Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

(2018) Jessica Idowu et al.   Scientific Reports

The association between autosomal dominant polycystic kidney disease and cancer

(2018) Ke Sun et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases

(2018) Mingzhu Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

(2018) Pedro Urquiza et al.   Science Translational Medicine

Targeting new cellular disease pathways in autosomal dominant polycystic kidney disease

(2017) Ming-Yang Chang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Superior efficacy of the antifungal agent ciclopirox olamine over gemcitabine in pancreatic cancer models

(2017) Chrysovalantou Mihailidou et al.   Oncotarget

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK

(2016) Hongyu Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Repositioning the Old Fungicide Ciclopirox for New Medical Uses

(2016) Tao Shen et al.   CURRENT PHARMACEUTICAL DESIGN

Ciclopirox enhances pancreatic islet health by modulating the unfolded protein response in diabetes

(2016) Chrysovalantou Mihailidou et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Antileukemia Effect of Ciclopirox Olamine Is Mediated by Downregulation of Intracellular Ferritin and Inhibition β-Catenin-c-Myc Signaling Pathway in Glucocorticoid Resistant T-ALL Cell Lines

(2016) Jianrong Wu et al.   PLoS One

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Macrophage and epithelial cell H-ferritin expression regulates renal inflammation

(2015) Subhashini Bolisetty et al.   KIDNEY INTERNATIONAL

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway

(2015) Hongyu Zhou et al.   Oncotarget

Polycystic Kidney Disease and Cancer after Renal Transplantation

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies

(2013) Mark D. Minden et al.   AMERICAN JOURNAL OF HEMATOLOGY

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

(2013) Ahmed A. Alkhateeb et al.   BREAST CANCER RESEARCH AND TREATMENT

Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury

(2013) Abolfazl Zarjou et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease

(2013) P. Hatamizadeh et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

(2012) Katharina Hopp et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferritin Stimulates Oligodendrocyte Genesis in the Adult Spinal Cord and Can Be Transferred from Macrophages to NG2 Cells In Vivo

(2012) D. L. Schonberg et al.   JOURNAL OF NEUROSCIENCE

Ferritin Blocks Inhibitory Effects of Two-Chain High Molecular Weight Kininogen (HKa) on Adhesion and Survival Signaling in Endothelial Cells

(2012) Lia Tesfay et al.   PLoS One

Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling

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Wnt Inhibitor Screen Reveals Iron Dependence of  -Catenin Signaling in Cancers

(2011) S. Song et al.   CANCER RESEARCH

mTOR signaling in polycystic kidney disease

(2011) Oxana Ibraghimov-Beskrovnaya et al.   TRENDS IN MOLECULAR MEDICINE

Activation of Notch signaling pathway in HIV-associated nephropathy

(2010) Madhulika Sharma et al.   AIDS

Ciclopirox

(2010) Alessandro Subissi et al.   DRUGS

The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice

(2010) Wei-Jian Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The cell biology of polycystic kidney disease

(2010) Hannah C. Chapin et al.   JOURNAL OF CELL BIOLOGY

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

(2009) Y. Eberhard et al.   BLOOD

Specific iron chelators determine the route of ferritin degradation

(2009) I. De Domenico et al.   BLOOD

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells

(2008) Richard G. Ruddell et al.   HEPATOLOGY

Molecular, physiological and clinical aspects of the iron storage protein ferritin

(2007) Koichi Orino et al.   VETERINARY JOURNAL