Stem Cell Therapy for Alzheimer’s Disease: A Scoping Review for 2017–2022

Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

(2022) Sen Liu et al.   Journal of Neuroinflammation

Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential

(2022) Lina Gao et al.   Translational Neurodegeneration

Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade

(2022) Miren Revuelta et al.   Frontiers in Cellular Neuroscience

Mitigating Effect of Estrogen in Alzheimer’s Disease-Mimicking Cerebral Organoid

(2022) Jennifer Yejean Kim et al.   Frontiers in Neuroscience

Membrane-Free Stem Cells and Pyridoxal 5′-Phosphate Synergistically Enhance Cognitive Function in Alzheimer’s Disease Mouse Model

(2022) Ji Myung Choi et al.   Antioxidants

Stem cells from human exfoliated deciduous teeth relieves Alzheimer’s disease symptoms in SAMP8 mice by up-regulating the PPARγ pathway

(2022) Xiaoshuang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial genome mutations and neuronal dysfunction of induced pluripotent stem cells derived from patients with Alzheimer's disease

(2022) Yeonmi Lee et al.   CELL PROLIFERATION

Stem cell-based therapy as a promising approach in Alzheimer's disease: current perspectives on novel treatment

(2021) Saeid Bagheri-Mohammadi   CELL AND TISSUE BANKING

A Nanoformulation‐Mediated Multifunctional Stem Cell Therapy with Improved Beta‐Amyloid Clearance and Neural Regeneration for Alzheimer's Disease

(2021) Dehua Huang et al.   ADVANCED MATERIALS

Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease

(2021) Lauren A. Apodaca et al.   Alzheimers Research & Therapy

Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model

(2021) Mei-Hong Lu et al.   Frontiers in Aging Neuroscience

Mesenchymal stem cell‐conditioned medium attenuates the retinal pathology in amyloid‐β‐induced rat model of Alzheimer's disease: Underlying mechanisms

(2021) Shu‐Chun Kuo et al.   AGING CELL

Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles

(2021) Jin Wang et al.   Stem Cell Research

Generation of induced pluripotent stem cell line (ZZUi0024-A) from a 51-year-old patient with APP gene mutation in Alzheimer’ s disease

(2021) Zhuoya Wang et al.   Stem Cell Research

Intravenous administration of mesenchymal stem cells reduces Tau phosphorylation and inflammation in the 3xTg-AD mouse model of Alzheimer's disease

(2021) Amanda Ferreira Neves et al.   EXPERIMENTAL NEUROLOGY

Mesenchymal stem cell therapies for Alzheimer’s disease: preclinical studies

(2021) Xiaorong Zhao et al.   METABOLIC BRAIN DISEASE

Potential application of human neural crest-derived nasal turbinate stem cells for the treatment of neuropathology and impaired cognition in models of Alzheimer’s disease

(2021) Jung Yeon Lim et al.   Stem Cell Research & Therapy

Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial

(2021) Hee Jin Kim et al.   Alzheimers Research & Therapy

SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

(2021) Wei Fan et al.   eLife

Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer’s Disease

(2021) Enrique Armijo et al.   Cells

Induced Pluripotent Stem Cells (iPSCs)—Roles in Regenerative Therapies, Disease Modelling and Drug Screening

(2021) Mourad A. M. Aboul-Soud et al.   Cells

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer’s Disease Pathology and Improve Cognitive Deficits

(2021) Yi-An Chen et al.   Biomedicines

Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice

(2021) Han Wang et al.   Cell Death Discovery

Stem cells from human exfoliated deciduous teeth affect mitochondria and reverse cognitive decline in a senescence-accelerated mouse prone 8 model

(2021) Wenhuan Guo et al.   CYTOTHERAPY

Engrafted stem cell therapy for Alzheimer's disease: A promising treatment strategy with clinical outcome

(2021) Salwa et al.   JOURNAL OF CONTROLLED RELEASE

An update on Alzheimer's disease: Immunotherapeutic agents, stem cell therapy and gene editing

(2021) Aryaman Girish Patwardhan et al.   LIFE SCIENCES

Fe3O4@polydopamine nanoparticle-loaded human umbilical cord mesenchymal stem cells improve the cognitive function in Alzheimer's disease mice by promoting hippocampal neurogenesis

(2021) Yuxiang Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy

(2021) Zhen-Zhen Quan et al.   Neural Regeneration Research

Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model

(2021) HyeJu Jeong et al.   Stem Cells International

Disrupted blood-brain barrier in 5×FAD mouse model of Alzheimer’s disease can be mimicked and repaired in vitro with neural stem cell-derived exosomes

(2020) Yanying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer’s Disease

(2020) Wei Wuli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stem Cells Could Be Considered as a Candidate for Further Studies in Cell-Based Therapy of Alzheimer’s Disease via Targeting the Signaling Pathways

(2020) Raheleh Farahzadi et al.   ACS Chemical Neuroscience

Therapeutic effect of mesenchymal stem cells in an animal model of Alzheimer’s disease evaluated by β-amyloid positron emission tomography imaging

(2020) Bok-Nam Park et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Combination Drug Therapy for the Management of Alzheimer’s Disease

(2020) Md. Tanvir Kabir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Effects of Melatonin-Treated Bone Marrow Mesenchymal Stem Cells (BMSC) in a Rat Model of Alzheimer's Disease

(2020) Mahdi Ramezani et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening

(2020) Chia-Yu Chang et al.   MOLECULES

Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis

(2020) Hong Wei et al.   Cell Death & Disease

Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms

(2020) Chuan Qin et al.   Translational Neurodegeneration

Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice

(2020) Giulia Santamaria et al.   CELL DEATH AND DIFFERENTIATION

Human Neural Stem Cells Encoding ChAT Gene Restore Cognitive Function via Acetylcholine Synthesis, Aβ Elimination, and Neuroregeneration in APPswe/PS1dE9 Mice

(2020) Dongsun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Feasibility and Efficacy of Intra-Arterial Administration of Embryonic Stem Cell Derived-Mesenchymal Stem Cells in Animal Model of Alzheimer’s Disease

(2020) Dong Yeol Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

Healthy lifestyle and the risk of Alzheimer dementia

(2020) Klodian Dhana et al.   NEUROLOGY

Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79-year-old patient with Alzheimer's disease having APOE3/4 genetic background

(2020) Qiuting Dai et al.   Stem Cell Research

Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus

(2020) Masako Nakano et al.   Scientific Reports

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia

(2020) Suzanne Craft et al.   JAMA Neurology

Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC-Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology

(2020) Jin Zhao et al.   Frontiers in Immunology

Mesenchymal Stem Cell-Conditioned Medium Improves Mitochondrial Dysfunction and Suppresses Apoptosis in Okadaic Acid-Treated SH-SY5Y Cells by Extracellular Vesicle Mitochondrial Transfer

(2020) Zhihua Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Human Induced Pluripotent Stem Cell-Derived Neural Cells from Alzheimer’s Disease Patients Exhibited Different Susceptibility to Oxidative Stress

(2020) Lin Zhang et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

(2020) Mengtian Guo et al.   Alzheimers Research & Therapy

Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together

(2019) Shohreh Majd et al.   Frontiers in Neuroscience

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

(2019) Katharina Meyer et al.   Cell Reports

The potential and limitations of induced pluripotent stem cells to achieve wound healing

(2019) Jolanta Gorecka et al.   Stem Cell Research & Therapy

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

Melatonin-pretreated adipose-derived mesenchymal stem cells efficeintly improved learning, memory, and cognition in an animal model of Alzheimer's disease

(2019) Ebrahim Nasiri et al.   METABOLIC BRAIN DISEASE

Prospects for the application of mesenchymal stem cells in Alzheimer's disease treatment

(2019) Forough Chakari-Khiavi et al.   LIFE SCIENCES

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances, and Limitations

(2019) Tannaz Akbari Kolagar et al.   Current Stem Cell Research & Therapy

A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration

(2019) Teresa Ubina et al.   Frontiers in Neuroscience

Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids

(2019) Mark Marzano et al.   Cells

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons

(2019) Maria Lo Giudice et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Hypoxic-conditioned medium from adipose tissue mesenchymal stem cells improved neuroinflammation through alternation of toll like receptor (TLR) 2 and TLR4 expression in model of Alzheimer's disease rats

(2019) Shima Mehrabadi et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondrial calcium signaling as a therapeutic target for Alzheimer’s disease

(2019) Aston Jiaxi Wu et al.   Current Alzheimer Research

Neural stem cell therapy for neurovascular injury in Alzheimer's disease

(2019) Austin C. Boese et al.   EXPERIMENTAL NEUROLOGY

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease

(2018) Xinxin Wang et al.   BEHAVIOURAL BRAIN RESEARCH

sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model

(2018) Seyeon Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A molecular approach in drug development for Alzheimer’s disease

(2018) Snezana Agatonovic-Kustrin et al.   BIOMEDICINE & PHARMACOTHERAPY

Ethical and Safety Issues of Stem Cell-Based Therapy

(2018) Vladislav Volarevic et al.   International Journal of Medical Sciences

Mesenchymal Stem Cell-Derived Extracellular Vesicles Suppresses iNOS Expression and Ameliorates Neural Impairment in Alzheimer’s Disease Mice

(2018) Shan-Shan Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Umbilical Cord Mesenchymal Stem Cells Conditioned Medium Promotes Aβ25-35 phagocytosis by Modulating Autophagy and Aβ-Degrading Enzymes in BV2 Cells

(2018) Zhihao Xu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuronal and Glial Differentiation of Human Neural Stem Cells Is Regulated by Amyloid Precursor Protein (APP) Levels

(2018) Raquel Coronel et al.   MOLECULAR NEUROBIOLOGY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Establishment of induced pluripotent stem cell line (ZZUi009-A) from an Alzheimer's disease patient carrying a PSEN1 gene mutation

(2018) Yanlin Wang et al.   Stem Cell Research

Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease

(2018) Kyeong-Ah Kwak et al.   Stem Cells International

MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model

(2018) Linlin Han et al.   Frontiers in Neuroscience

Stem cell- and gene-based therapies as potential candidates in Alzheimer's therapy

(2018) Seyede Atefe Hosseini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

(2018) Kuo-Hsuan Chang et al.   MOLECULAR NEUROBIOLOGY

Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease

(2018) Lisa M. McGinley et al.   Scientific Reports

Stem cell therapy in Alzheimer’s disease: possible benefits and limiting drawbacks

(2018) Masoume Alipour et al.   MOLECULAR BIOLOGY REPORTS

Generation of induced pluripotent stem cell line (ZZUi0013-A) from a 65-year-old patient with a novel MEOX2 gene mutation in Alzheimer's disease

(2018) Yanlin Wang et al.   Stem Cell Research

Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer disease

(2018) Banafshe Esmaeilzade et al.   PHYSIOLOGY & BEHAVIOR

Brain-derived neurotrophic factor modified human umbilical cord mesenchymal stem cells-derived cholinergic-like neurons improve spatial learning and memory ability in Alzheimer’s disease rats

(2018) Weiwei Hu et al.   BRAIN RESEARCH

Treating cognitive impairment with transcranial low level laser therapy

(2017) Jack C. de la Torre   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Administrations of human adult ischemia-tolerant mesenchymal stem cells and factors reduce amyloid beta pathology in a mouse model of Alzheimer's disease

(2017) Taoufiq Harach et al.   NEUROBIOLOGY OF AGING

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease

(2016) Allal Boutajangout et al.   Current Alzheimer Research

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review

(2016) Brandon Lucke-Wold et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis

(2016) Thangavelu Soundara Rajan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy

(2016) Juan Yang et al.   Molecular Neurodegeneration

History of Neural Stem Cell Research and Its Clinical Application

(2016) Yasushi TAKAGI   NEUROLOGIA MEDICO-CHIRURGICA

Signaling pathway cross talk in Alzheimer’s disease

(2014) Juan A Godoy et al.   Cell Communication and Signaling