Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC-Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

(2019) Neta Rosenzweig et al.   Nature Communications

Can immunotherapy treat neurodegeneration?

(2017) Michal Schwartz   SCIENCE

APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins

(2017) Suzanne Guénette et al.   Frontiers in Molecular Neuroscience

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

FOXN1 recombinant protein enhances T-cell regeneration after hematopoietic stem cell transplantation in mice

(2016) Yinhong Song et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice

(2016) Rong Hu et al.   Stem Cells Translational Medicine

Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Yvonne S. Eisele et al.   ACTA NEUROPATHOLOGICA

Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease

(2015) Kurt R. Stover et al.   BEHAVIOURAL BRAIN RESEARCH

Assessing rodent hippocampal involvement in the novel object recognition task. A review

(2015) Sarah J. Cohen et al.   BEHAVIOURAL BRAIN RESEARCH

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model

(2015) Stephen T. Yeung et al.   BRAIN RESEARCH BULLETIN

Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis

(2015) Min Su et al.   JOURNAL OF AUTOIMMUNITY

Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS

(2015) G. Kunis et al.   JOURNAL OF NEUROSCIENCE

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells

(2015) Min Su et al.   Scientific Reports

The dynamics of monocytes and microglia in Alzheimer’s disease

(2015) Peter Thériault et al.   Alzheimers Research & Therapy

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation

(2014) Michal Schwartz et al.   JOURNAL OF AUTOIMMUNITY

IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology

(2014) Isabelle St-Amour et al.   Journal of Neuroinflammation

CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles

(2014) C. Raposo et al.   JOURNAL OF NEUROSCIENCE

Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress

(2014) P M Maras et al.   MOLECULAR PSYCHIATRY

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

(2013) Michal Schwartz et al.   EMBO JOURNAL

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease

(2013) Gaëlle Naert et al.   Journal of Molecular Cell Biology

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Recombinant IL-7/HGFβ efficiently induces transplantable murine hematopoietic stem cells

(2012) Laijun Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Purified enzymes improve isolation and characterization of the adult thymic epithelium

(2012) Natalie Seach et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance T-cell reconstitution after allogeneic bone marrow transplantation

(2011) L. Lai et al.   BLOOD

Inflammation and axon regeneration

(2011) Larry I. Benowitz et al.   CURRENT OPINION IN NEUROLOGY

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

(2011) Anat London et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice

(2011) Dany Arsenault et al.   PLoS One

Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution

(2010) Liguang Sun et al.   AGING CELL

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

In vivo Antitumor Activity of a Recombinant IL-7/HGF  Hybrid Cytokine in Mice

(2010) L. Lai et al.   CANCER RESEARCH

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Depression and immunity: A role for T cells?

(2009) Andrew H. Miller   BRAIN BEHAVIOR AND IMMUNITY

Age-associated declines in immune system development and function: causes, consequences, and reversal

(2009) Kenneth Dorshkind et al.   CURRENT OPINION IN IMMUNOLOGY

Immunity in the Elderly: The Role of the Thymus

(2009) R. Aspinall et al.   JOURNAL OF COMPARATIVE PATHOLOGY

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

(2009) S. A. Wolf et al.   JOURNAL OF IMMUNOLOGY

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9

(2009) Maya Koronyo-Hamaoui et al.   JOURNAL OF NEUROCHEMISTRY

Key Research Opportunities in Immune System Aging

(2009) S. L. Swain et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

Generation of Thymic Epithelial Cell Progenitors by Mouse Embryonic Stem Cells

(2009) Laijun Lai et al.   STEM CELLS

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2008)   ARCHIVES OF NEUROLOGY

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunity to self and self-maintenance: what can tumor immunology teach us about ALS and Alzheimer's disease?

(2008) M SCHWARTZ et al.   TRENDS IN PHARMACOLOGICAL SCIENCES