Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model

Human Neural Stem Cells Encoding ChAT Gene Restore Cognitive Function via Acetylcholine Synthesis, Aβ Elimination, and Neuroregeneration in APPswe/PS1dE9 Mice

(2020) Dongsun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defining an Upstream VEGF (Vascular Endothelial Growth Factor) Priming Signature for Downstream Factor-Induced Endothelial Cell-Pericyte Tube Network Coassembly

(2020) Stephanie L.K. Bowers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional multipotency of stem cells: Biological traits gleaned from neural progeny studies

(2019) Yang D. Teng   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

(2019) Shaowei Guo et al.   ACS Nano

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer’s disease

(2018) Nils Richter et al.   BRAIN

The Route by Which Intranasally Delivered Stem Cells Enter the Central Nervous System

(2018) Carlos Galeano et al.   CELL TRANSPLANTATION

Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease

(2018) Igor V. Kurochkin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease

(2018) Lisa M. McGinley et al.   Scientific Reports

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1

(2018) Mei-Hong Lu et al.   EXPERIMENTAL NEUROLOGY

Neural microvascular pericytes contribute to human adult neurogenesis

(2018) Ramin M. Farahani et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

(2018) Qingyi Ma et al.   Molecular Neurodegeneration

Brain Pericytes As Mediators of Neuroinflammation

(2017) Justin Rustenhoven et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

High Plasticity of New Granule Cells in the Aging Hippocampus

(2017) Mariela F. Trinchero et al.   Cell Reports

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Developments in intracerebral stem cell grafts

(2015) Stephanny Reyes et al.   Expert Review of Neurotherapeutics

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

(2015) Il-Shin Lee et al.   Molecular Neurodegeneration

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Transplantation of NSC-derived cholinergic neuron-like cells improves cognitive function in APP/PS1 transgenic mice

(2015) G. Gu et al.   NEUROSCIENCE

Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model

(2015) J A Kim et al.   Cell Death & Disease

Developments in intracerebral stem cell grafts

(2015) Stephanny Reyes et al.   Expert Review of Neurotherapeutics

ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models

(2015) Wei Yue et al.   Stem Cell Reports

Is synaptic loss a unique hallmark of Alzheimer's disease?

(2014) Stephen W. Scheff et al.   BIOCHEMICAL PHARMACOLOGY

Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old

(2014) John L. Robinson et al.   BRAIN

Advances in the therapy of Alzheimer’s disease: targeting amyloid beta and tau and perspectives for the future

(2014) Harald Hampel et al.   Expert Review of Neurotherapeutics

Neural Stem Cell Transplants Improve Cognitive Function Without Altering Amyloid Pathology in an APP/PS1 Double Transgenic Model of Alzheimer’s Disease

(2014) Wei Zhang et al.   MOLECULAR NEUROBIOLOGY

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Repairing Neural Injuries Using Human Umbilical Cord Blood

(2012) Tao Sun et al.   MOLECULAR NEUROBIOLOGY

Drug delivery to the brain in Alzheimer's disease: Consideration of the blood–brain barrier

(2011) William A. Banks   ADVANCED DRUG DELIVERY REVIEWS

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis

(2011) Sei-ichiro Motegi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intranasal delivery of stem cells to the brain

(2011) Yongjun Jiang et al.   Expert Opinion on Drug Delivery

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

(2010) J. Scott Miners et al.   BRAIN PATHOLOGY

Stem cells in human neurodegenerative disorders — time for clinical translation?

(2010) Olle Lindvall et al.   JOURNAL OF CLINICAL INVESTIGATION

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA