An update on Alzheimer's disease: Immunotherapeutic agents, stem cell therapy and gene editing

Trends in life expectancy: did the gap between the healthy and the ill widen or close?

(2020) Anna C. Meyer et al.   BMC Medicine

Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s disease

(2020) Sahil Khan et al.   Current Neuropharmacology

Biochemical Markers in Alzheimer’s Disease

(2020) Alessandro Rabbito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options

(2019) Jeffrey L. Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

In vivo neuronal gene editing via CRISPR–Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer’s disease

(2019) Hanseul Park et al.   NATURE NEUROSCIENCE

On the Etiopathogenesis and Pathophysiology of Alzheimer’s Disease: A Comprehensive Theoretical Review

(2019) Tobore Onojighofia Tobore   JOURNAL OF ALZHEIMERS DISEASE

Understanding the Amyloid Hypothesis in Alzheimer’s Disease

(2019) Giulia Paroni et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer Precision Medicine Initiative

(2019) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

(2019) Lisa Vermunt et al.   Alzheimers & Dementia

Target Engagement in an Alzheimer Trial: Crenezumab Lowers Aβ Oligomers in CSF

(2019) Ting Yang et al.   ANNALS OF NEUROLOGY

Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial

(2019) Adam L Boxer et al.   LANCET NEUROLOGY

The viral protein corona directs viral pathogenesis and amyloid aggregation

(2019) Kariem Ezzat et al.   Nature Communications

Aging and Alzheimer's disease pathology

(2019) Renpei Sengoku   NEUROPATHOLOGY

Biomarker definitions and their applications

(2018) Robert M Califf   EXPERIMENTAL BIOLOGY AND MEDICINE

Precision Medicine

(2018) Alan R. Weil   HEALTH AFFAIRS

Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls

(2018) Einar M. Sigurdsson   JOURNAL OF ALZHEIMERS DISEASE

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

(2018) Paul J. Cheng-Hathaway et al.   Molecular Neurodegeneration

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Adeno-Associated Viral Vector (Serotype 2)–Nerve Growth Factor for Patients With Alzheimer Disease

(2018) Michael S. Rafii et al.   JAMA Neurology

STIM1 deficiency is linked to Alzheimer’s disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry

(2018) Carlos Pascual-Caro et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

(2018) Xianyuan Xiang et al.   Molecular Neurodegeneration

Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling

(2018) Jacob C. Garza et al.   Translational Psychiatry

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

(2018) Jacqueline P. Robbins et al.   Frontiers in Neuroscience

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

(2018) Christy O.Y. Hung et al.   Cell Reports

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer’s Disease Skin Fibroblasts

(2017) Keiichi Inoue et al.   Cell Reports

Antibody Therapeutics Targeting Aβ and Tau

(2017) Gilbert Gallardo et al.   Cold Spring Harbor Perspectives in Medicine

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons

(2017) Maitane Ortiz-Virumbrales et al.   Acta Neuropathologica Communications

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

(2016) Adam C. Naj et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain

(2016) Merina Varghese et al.   JOURNAL OF ALZHEIMERS DISEASE

Non-Phosphorylated Tau as a Potential Biomarker of Alzheimer’s Disease: Analytical and Diagnostic Characterization

(2016) Piotr Lewczuk et al.   JOURNAL OF ALZHEIMERS DISEASE

PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model

(2016) Loukia Katsouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Dopaminergic Modulation of Cortical Plasticity in Alzheimer’s Disease Patients

(2014) Giacomo Koch et al.   NEUROPSYCHOPHARMACOLOGY

Herpes virus in Alzheimer's disease: relation to progression of the disease

(2013) Ilaria Carbone et al.   NEUROBIOLOGY OF AGING

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease

(2012) Robert Howard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

(2011) Susanne Ostrowitzki   ARCHIVES OF NEUROLOGY

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

(2011) Simone Isbert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Stem cells for the treatment of neurodegenerative diseases

(2011) Elise Dantuma et al.   Stem Cell Research & Therapy

Biodemography of human ageing

(2010) James W. Vaupel   NATURE

Adult neural stem cells in the mammalian central nervous system

(2009) Dengke K Ma et al.   CELL RESEARCH

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study

(2008) P Lewczuk et al.   MOLECULAR PSYCHIATRY

Neural Stem Cells Improve Learning and Memory in Rats with Alzheimer’s Disease

(2008) Shuliang Wu et al.   PATHOBIOLOGY

Genetic modification of stem cells for transplantation

(2007) M. Ian Phillips et al.   ADVANCED DRUG DELIVERY REVIEWS