PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia

The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration

(2022) Olivier Mercey et al.   PLOS BIOLOGY

Multiple ciliary localization signals control INPP5E ciliary targeting

(2022) Dario Cilleros-Rodriguez et al.   eLife

Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis

(2021) Ali S. Sharif et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The exosome journey: from biogenesis to uptake and intracellular signalling

(2021) Sonam Gurung et al.   Cell Communication and Signaling

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation

(2021) Sun-Ok Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states

(2021) Xueqing Chen et al.   Scientific Reports

Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles

(2021) Ann-Kathrin Volz et al.   Nature Communications

Crag/Rab10/Ehbp1 regulate the basolateral transport of Na+K+ATPase in Drosophila photoreceptors

(2020) Yuri Nakamura et al.   JOURNAL OF CELL SCIENCE

Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

(2020) Jyothi S Akella et al.   eLife

Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis

(2020) Malini Mukherjee et al.   FASEB JOURNAL

Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis

(2020) Jia‐Rong Fan et al.   EMBO REPORTS

Tissue- and isoform-specific protein complex analysis with natively processed bait proteins

(2020) Tina Beyer et al.   Journal of Proteomics

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endosomal signalling via exosome surface TGFβ-1

(2019) Ganesh Vilas Shelke et al.   Journal of Extracellular Vesicles

An intrinsic compartmentalization code for peripheral membrane proteins in photoreceptor neurons

(2019) Nycole A. Maza et al.   JOURNAL OF CELL BIOLOGY

Rab7 regulates primary cilia disassembly through cilia excision

(2019) Guang Wang et al.   JOURNAL OF CELL BIOLOGY

Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment

(2018) Stefanie Kristine Kösling et al.   BIOLOGICAL CHEMISTRY

Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6

(2018) Bilal M. Qureshi et al.   Nature Communications

Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells

(2018) Helen Louise May-Simera et al.   Cell Reports

The small GTPase Rab28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium

(2018) Guoxin Ying et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UBL3 modification influences protein sorting to small extracellular vesicles

(2018) Hiroshi Ageta et al.   Nature Communications

A novel PDE6D mutation in a patient with Joubert syndrome type 22 (JBTS22)

(2018) André Mégarbané et al.   European Journal of Medical Genetics

Review of Ocular Manifestations of Joubert Syndrome

(2018) Stephanie F. Wang et al.   Genes

Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release

(2017) Raquel Y. Salinas et al.   JOURNAL OF CELL BIOLOGY

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

(2017) Qiyu Wang et al.   Nature Communications

Comparative Analysis of Ciliary Membranes and Ectosomes

(2016) Huan Long et al.   CURRENT BIOLOGY

INPP5E regulates phosphoinositide-dependent cilia transition zone function

(2016) Jennifer M. Dyson et al.   JOURNAL OF CELL BIOLOGY

Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development

(2016) David Razafsky et al.   MOLECULAR BIOLOGY OF THE CELL

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

(2016) Eyad Kalawy Fansa et al.   Nature Communications

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

(2016) Karsten Boldt et al.   Nature Communications

RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner

(2016) Nirmal Dutta et al.   Biology Open

The N- and C-terminal ends of RPGR can bind to PDE6 

(2015) E. K. Fansa et al.   EMBO REPORTS

RPGR: Its role in photoreceptor physiology, human disease, and future therapies

(2015) Roly D. Megaw et al.   EXPERIMENTAL EYE RESEARCH

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

(2015) Muqing Cao et al.   eLife

Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications

(2014) Charuta C. Palsuledesai et al.   ACS Chemical Biology

Membrane Protein Transport in Photoreceptors: The Function of PDE 

(2014) W. Baehr   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Prenylation defects in inherited retinal diseases

(2014) Susanne Roosing et al.   JOURNAL OF MEDICAL GENETICS

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Mutations in RAB28, Encoding a Farnesylated Small GTPase, Are Associated with Autosomal-Recessive Cone-Rod Dystrophy

(2013) Susanne Roosing et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A HomozygousPDE6DMutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

(2013) Sophie Thomas et al.   HUMAN MUTATION

Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys

(2013) S. Y. Choi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rabs and other small GTPases in ciliary transport

(2011) Yi Shan Lim et al.   BIOLOGY OF THE CELL

The role of RPGR in cilia formation and actin stability

(2011) Milica Gakovic et al.   HUMAN MOLECULAR GENETICS

The Small GTPase Cdc42 Is Necessary for Primary Ciliogenesis in Renal Tubular Epithelial Cells

(2011) Xiaofeng Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arls squeeze the fat out

(2011) Roger L Williams   Nature Chemical Biology

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

(2011) Francesc R Garcia-Gonzalo et al.   NATURE GENETICS

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library

(2008) Jurre Hageman et al.   CELL STRESS & CHAPERONES

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY