Prospective Epigenetic Actions of Organo-Sulfur Compounds against Cancer: Perspectives and Molecular Mechanisms

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases

(2022) Ramla Muhammad Kamal et al.   MOLECULES

Combinatorial epigenetic mechanisms of sulforaphane, genistein and sodium butyrate in breast cancer inhibition

(2022) Manvi Sharma et al.   EXPERIMENTAL CELL RESEARCH

Bioactive compounds modulating Toll-like 4 receptor (TLR4)-mediated inflammation: pathways involved and future perspectives

(2022) Karen S. Coutinho-Wolino et al.   NUTRITION RESEARCH

Diallyl thiosulfinate enhanced the anti-cancer activity of dexamethasone in the side population cells of multiple myeloma by promoting miR-127-3p and deactivating the PI3K/AKT signaling pathway

(2021) Wenfeng He et al.   BMC CANCER

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma

(2021) Melina Mitsiogianni et al.   INVESTIGATIONAL NEW DRUGS

The potential neuroprotective effect of allicin and melatonin in acrylamide-induced brain damage in rats

(2021) Hanan A. Edres et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Dietary Isothiocyanates, Sulforaphane and 2-Phenethyl Isothiocyanate, Effectively Impair Vibrio cholerae Virulence

(2021) Klaudyna Krause et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effects Of Isothiocyanates Against Alzheimer's Disease

(2021) Mohammad Asif et al.   Current Traditional Medicine

Protective effect of diallyl disulfide against cerulein-induced acute pancreatitis and associated lung injury in mice

(2020) Marimuthu Mathan Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites

(2020) Shara Francesca Rapa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression miR-486-3p Promoted by Allicin Enhances Temozolomide Sensitivity in Glioblastoma Via Targeting MGMT

(2020) Henggang Wu et al.   NEUROMOLECULAR MEDICINE

Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma

(2020) Melina Mitsiogianni et al.   EUROPEAN JOURNAL OF NUTRITION

SAMD14 promoter methylation is strongly associated with gene expression and poor prognosis in gastric cancer

(2020) Xiaoyang Xu et al.   International Journal of Clinical Oncology

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice

(2020) Hongxing Zhang et al.   MEDIATORS OF INFLAMMATION

Allicin suppresses growth and metastasis of gastric carcinoma: the key role of microRNA-383-5p-mediated inhibition of ERBB4 signaling

(2020) Qing Lv et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Phenethyl isothiocyanate reduces breast cancer stem cell-like properties by epigenetic reactivation of CDH1

(2020) Taolan Zhang et al.   ONCOLOGY REPORTS

Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation

(2020) Tiziana Latronico et al.   INFLAMMOPHARMACOLOGY

The nephroprotective effects of allicin and ascorbic acid against cisplatin-induced toxicity in rats

(2019) Mohamed M. Abdel-Daim et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1

(2019) Riya Gupta et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Benzyl isothiocyanate promotes miR‐99a expression through ERK/AP‐1‐dependent pathway in bladder cancer cells

(2019) Te‐Fu Tsai et al.   ENVIRONMENTAL TOXICOLOGY

Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis

(2019) Luo Chen et al.   PHYTOMEDICINE

Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer – contradictory effects and future perspectives

(2019) Parham Jabbarzadeh Kaboli et al.   BIOMEDICINE & PHARMACOTHERAPY

Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells

(2019) Patrick Wellington da Silva dos Santos et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparison of the inhibitory potential of benzyl isothiocyanate and phenethyl isothiocyanate on Shiga toxin-producing and enterotoxigenic Escherichia coli

(2019) Chun-Xue Yang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Sulforaphane promotes apoptosis, and inhibits proliferation and self-renewal of nasopharyngeal cancer cells by targeting STAT signal through miRNA-124-3p

(2018) Xiqing Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms

(2018) Kendra J. Royston et al.   EXPERIMENTAL CELL RESEARCH

HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells

(2018) Chunyu Cao et al.   INTERNATIONAL JOURNAL OF CANCER

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation

(2018) Bidisha Paul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alcohol and Cancer: A Statement of the American Society of Clinical Oncology

(2018) Noelle K. LoConte et al.   JOURNAL OF CLINICAL ONCOLOGY

Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells

(2018) Linbo Gao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells

(2018) Chao Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation

(2018) Katarzyna Lubecka et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Purified sulforaphane from broccoli ( Brassica oleracea var. italica ) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells

(2018) Sholeh Kiani et al.   GENE

Diallyl disulfide suppresses FOXM1-mediated proliferation and invasion in osteosarcoma by upregulating miR-134

(2018) Yonggang Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection

(2018) Ved Prakash Dwivedi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Obesity and cancer risk: Emerging biological mechanisms and perspectives

(2018) Konstantinos I. Avgerinos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells

(2017) Jianyun Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction

(2017) Chia-Ming Liu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains, as a Vapor

(2017) Jana Reiter et al.   MOLECULES

Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy

(2017) Mohammad Hassan Baig et al.   SEMINARS IN CANCER BIOLOGY

Role of phytochemicals in the modulation of miRNA expression in cancer

(2017) Trishna Debnath et al.   Food & Function

Nutrients and the Pancreas: An Epigenetic Perspective

(2017) Andee Weisbeck et al.   Nutrients

Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells

(2017) Anna Lewinska et al.   Theranostics

No Smoke—Just Cancer-Causing Chemicals

(2017) Mitchell H. Katz   JAMA Internal Medicine

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

(2017) Jung Eun Park et al.   Scientific Reports

Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways

(2016) Da-xuan Wang et al.   ACTA PHARMACOLOGICA SINICA

Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines

(2016) Ata Abbas et al.   Biochemistry and Cell Biology

Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity

(2016) Li-Li Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers

(2016) J.-M. Yuan et al.   Cancer Prevention Research

Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194

(2016) Chengyue Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

Upregulation of miR-34a by diallyl disulfide suppresses invasion and induces apoptosis in SGC-7901 cells through inhibition of the PI3K/Akt signaling pathway

(2016) GUOJUN WANG et al.   Oncology Letters

Dual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin

(2015) Suresh Kumar   INDIAN JOURNAL OF PHARMACOLOGY

Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells

(2015) Katarzyna Lubecka-Pietruszewska et al.   Journal of Nutrigenetics and Nutrigenomics

Aberrant SOX11 promoter methylation is associated with poor prognosis in gastric cancer

(2015) Xiaoyang Xu et al.   CELLULAR ONCOLOGY

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

(2015) Praveen Rajendran et al.   Clinical Epigenetics

Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation by Sulforaphane

(2014) Z.-Y. Su et al.   Cancer Prevention Research

Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages by suppressing the Toll-like receptor 4/nuclear factor-κB pathway

(2014) HYE HYEON LEE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

(2014) Carmen P. Wong et al.   PLoS One

Lavage with Allicin in Combination with Vancomycin Inhibits Biofilm Formation by Staphylococcus epidermidis in a Rabbit Model of Prosthetic Joint Infection

(2014) Haohan Zhai et al.   PLoS One

Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a

(2014) Xiangsheng Xiao et al.   PLoS One

Retinoblastoma (RB1) pocket domain mutations and promoter hyper-methylation in head and neck cancer

(2014) Maimoona Sabir et al.   CELLULAR ONCOLOGY

Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-κB and STAT3 as potential targets

(2013) Hyung-Jun Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation

(2013) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells

(2013) Katherine Liu et al.   Cancer Cell International

Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22

(2013) Hailin Tang et al.   CANCER LETTERS

Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF

(2013) Chunguang Yu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation

(2013) Chin-Shiu Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer

(2013) Ondrej Slaby et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Phenethylisothiocyanate Alters Site- and Promoter-Specific Histone Tail Modifications in Cancer Cells

(2013) Yi Liu et al.   PLoS One

The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability

(2012) Benjamin L. Predmore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

In vitro efficacies of various isothiocyanates from cruciferous vegetables as antimicrobial agents against foodborne pathogens and spoilage bacteria

(2012) Adjélé Eli Wilson et al.   FOOD CONTROL

Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells

(2012) Yujuan Shan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Diallyl Disulfide-Induced Apoptosis in a Breast-Cancer Cell Line (MCF-7) May Be Caused by Inhibition of Histone Deacetylation

(2012) Mohammed O. Altonsy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The Attenuation of Early Benzo(a)Pyrene-Induced Carcinogenic Insults by Diallyl Disulfide (DADS) in MCF-10A Cells

(2012) Yasmeen M. Nkrumah-Elie et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Chronic Inflammation in Cancer Development

(2012) Gabriele Multhoff et al.   Frontiers in Immunology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells

(2011) Mikiko Kawata et al.   JOURNAL OF BIOCHEMISTRY

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly

(2011) Praveen Rajendran et al.   Molecular Cancer

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells

(2011) Anna Hsu et al.   Clinical Epigenetics

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

Tissue Transglutaminase Promotes Drug Resistance and Invasion by Inducing Mesenchymal Transition in Mammary Epithelial Cells

(2010) Anupam Kumar et al.   PLoS One

Sulforaphane- and Phenethyl Isothiocyanate–Induced Inhibition of Aflatoxin B1–Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 Genotype and CYP3A4 Gene Expression

(2010) Kerstin Gross-Steinmeyer et al.   TOXICOLOGICAL SCIENCES

Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells

(2009) Brian Hutzen et al.   Cancer Cell International

Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori-Infected Mice and Humans

(2009) A. Yanaka et al.   Cancer Prevention Research

Imaging and cancer: A review

(2008) Leonard Fass   Molecular Oncology