Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma

Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma

(2020) Melina Mitsiogianni et al.   EUROPEAN JOURNAL OF NUTRITION

HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics

(2019) Andressa S. Laino et al.   Journal for ImmunoTherapy of Cancer

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas

(2019) Ophélia Maertens et al.   Cancer Discovery

Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma

(2019) Melina Mitsiogianni et al.   EUROPEAN JOURNAL OF NUTRITION

Mechanism of selective anticancer activity of isothiocyanates relies on differences in DNA damage repair between cancer and healthy cells

(2019) Aleksandra Hać et al.   EUROPEAN JOURNAL OF NUTRITION

Histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target

(2019) Elias Orouji et al.   INTERNATIONAL JOURNAL OF CANCER

Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis

(2019) Lu Yu et al.   CARCINOGENESIS

Roles and regulation of histone methylation in animal development

(2019) Ashwini Jambhekar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

(2019) James Ropa et al.   HAEMATOLOGICA

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

(2018) Adaobi Okonkwo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

From chemo-prevention to epigenetic regulation: The role of isothiocyanates in skin cancer prevention

(2018) Melina Mitsiogianni et al.   PHARMACOLOGY & THERAPEUTICS

Structure based identification and biological evaluation of novel and potent inhibitors of PCAF catalytic domain

(2018) Venkatesan Suryanarayanan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small molecule inhibitor of p300/CBP

(2018) Rui Wang et al.   MOLECULAR CANCER THERAPEUTICS

Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

(2018) Loren M. Lasko et al.   NATURE

MiR-200a Regulates CDK4/6 Inhibitor Effect by Targeting CDK6 in Metastatic Melanoma

(2017) Matias A. Bustos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epigenetics of skin cancer: Interventions by selected bioactive phytochemicals

(2017) Dhanamjai Penta et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells

(2017) Chris Shidal et al.   Oncotarget

The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo

(2017) Laurence Booth et al.   Oncotarget

Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells

(2017) Ye Gu et al.   Journal of Cancer

Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets

(2017) et al.   Genes

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance

(2016) A. Krumm et al.   CANCER RESEARCH

Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

(2016) Jiaqi Liu et al.   Journal of Translational Medicine

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

SET7/9 inhibits oncogenic activities through regulation of Gli-1 expression in breast cancer

(2016) Yongchun Song et al.   TUMOR BIOLOGY

In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells

(2016) Aleksandra Konic-Ristic et al.   Vojnosanitetski Pregled

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy

(2016) Yu-Li Jia et al.   Cell Death & Disease

The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target

(2016) Marta Di Martile et al.   Oncotarget

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer

(2016) Narsis Attar et al.   Cold Spring Harbor Perspectives in Medicine

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma

(2016) Mouadh Benamar et al.   EBioMedicine

Epigenetic regulation in human melanoma: past and future

(2015) Debina Sarkar et al.   Epigenetics

SET8 expression is associated with overall survival in gastric cancer

(2015) X.L. Shi et al.   GENETICS AND MOLECULAR RESEARCH

Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis

(2015) Chun-Ming Wong et al.   HEPATOLOGY

Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells

(2015) Sonam Sinha et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane

(2015) Matthew L. Fisher et al.   MOLECULAR CARCINOGENESIS

SET8 induces epithelial-mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1

(2015) LIEJUN HOU et al.   Molecular Medicine Reports

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation

(2015) K.V. Woan et al.   Molecular Oncology

Dietary sulforaphane inhibits histone deacetylase activity in B16 melanoma cells

(2015) Wu Yuanfeng et al.   Journal of Functional Foods

A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity

(2015) D Kramer et al.   Cell Death & Disease

Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression

(2015) Yoshimitsu Akiyama et al.   Oncotarget

Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

(2015) J M Gajer et al.   Oncogenesis

Histone H4 Lys 20 methyltransferase SET8 promotes androgen receptor-mediated transcription activation in prostate cancer

(2014) Lushuai Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetics of human melanoma: promises and challenges

(2014) A. Besaratinia et al.   Journal of Molecular Cell Biology

HDAC4: mechanism of regulation and biological functions

(2014) Zhengke Wang et al.   Epigenomics

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

microRNA-7 Suppresses the Invasive Potential of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Histone Methyltransferase SET8

(2013) Na Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells

(2013) Gai Yan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF

(2013) Chunguang Yu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

(2011) Dominique Ziech et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Benzyl Isothiocyanate-Mediated Inhibition of Histone Deacetylase Leads to NF- B Turnoff in Human Pancreatic Carcinoma Cells

(2010) S. Batra et al.   MOLECULAR CANCER THERAPEUTICS

Global Levels of Histone Modifications Predict Prognosis in Different Cancers

(2009) David B. Seligson et al.   AMERICAN JOURNAL OF PATHOLOGY

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

CpG Island Methylator Phenotype Predicts Progression of Malignant Melanoma

(2009) A. Tanemura et al.   CLINICAL CANCER RESEARCH

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

Oxidative stress, DNA methylation and carcinogenesis

(2008) Rodrigo Franco et al.   CANCER LETTERS

Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage

(2008) Satoru Yokoyama et al.   Pigment Cell & Melanoma Research