Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma

HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics

(2019) Andressa S. Laino et al.   Journal for ImmunoTherapy of Cancer

Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma

(2019) Melina Mitsiogianni et al.   EUROPEAN JOURNAL OF NUTRITION

Isothiocyanate-induced Cell Cycle Arrest in a Novel In Vitro Exposure Protocol of Human Malignant Melanoma (A375) Cells

(2019) THEODORA MANTSO et al.   ANTICANCER RESEARCH

Structures of isothiocyanates attributed to reactive oxygen species generation and microtubule depolymerization in HepG2 cells

(2018) Piman Pocasap et al.   BIOMEDICINE & PHARMACOTHERAPY

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

(2018) Adaobi Okonkwo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

From chemo-prevention to epigenetic regulation: The role of isothiocyanates in skin cancer prevention

(2018) Melina Mitsiogianni et al.   PHARMACOLOGY & THERAPEUTICS

Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors

(2018) Wenchao Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small molecule inhibitor of p300/CBP

(2018) Rui Wang et al.   MOLECULAR CANCER THERAPEUTICS

Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells

(2018) Fan Yang et al.   LIFE SCIENCES

HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma

(2017) Stuart J. Gallagher et al.   INTERNATIONAL JOURNAL OF CANCER

The impact of cruciferous vegetable isothiocyanates on histone acetylation and histone phosphorylation in bladder cancer

(2017) Besma Abbaoui et al.   Journal of Proteomics

Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells

(2017) Yoon-Jin Lee et al.   Molecular Medicine Reports

Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells

(2017) Ye Gu et al.   Journal of Cancer

Development of a Novel Experimental In Vitro Model of Isothiocyanate-induced Apoptosis in Human Malignant Melanoma Cells

(2016) THEODORA MANTSO et al.   ANTICANCER RESEARCH

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance

(2016) A. Krumm et al.   CANCER RESEARCH

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription

(2016) Yasushi Takemoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

(2016) Jiaqi Liu et al.   Journal of Translational Medicine

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

SET7/9 inhibits oncogenic activities through regulation of Gli-1 expression in breast cancer

(2016) Yongchun Song et al.   TUMOR BIOLOGY

Genetics and epigenetics of melanoma

(2016) Xiao-Ying Zhang et al.   Oncology Letters

Time - and Concentration - Dependent Effects of Resveratrol on miR 15a and miR16-1 Expression and Apoptosis in the CCRF-CEM Acute Lymphoblastic Leukemia Cell Line

(2015) Ako Azimi et al.   Asian Pacific Journal of Cancer Prevention

SET8 expression is associated with overall survival in gastric cancer

(2015) X.L. Shi et al.   GENETICS AND MOLECULAR RESEARCH

Epigenetic therapy as a novel approach in hepatocellular carcinoma

(2015) Ioannis Anestopoulos et al.   PHARMACOLOGY & THERAPEUTICS

Dietary sulforaphane inhibits histone deacetylase activity in B16 melanoma cells

(2015) Wu Yuanfeng et al.   Journal of Functional Foods

Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression

(2015) Yoshimitsu Akiyama et al.   Oncotarget

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade

(2015) D. M. Woods et al.   Cancer Immunology Research

Histone H4 Lys 20 methyltransferase SET8 promotes androgen receptor-mediated transcription activation in prostate cancer

(2014) Lushuai Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of dual inhibition property of newly discovered inhibitors against PCAF and GCN5 throughin silicoscreening, molecular dynamics simulation and DFT approach

(2014) Venkatesan Suryanarayanan et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Melanoma epigenetics: novel mechanisms, markers and medicines

(2014) Jonathan J Lee et al.   LABORATORY INVESTIGATION

Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

(2014) Carmen P. Wong et al.   PLoS One

Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells

(2013) K. Rudolf et al.   APOPTOSIS

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways

(2013) S-H Huang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells

(2013) Gai Yan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice

(2013) Huifeng Yu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Structural Interactions Dictate the Kinetics of Macrophage Migration Inhibitory Factor Inhibition by Different Cancer-Preventive Isothiocyanates

(2012) Gregg V. Crichlow et al.   BIOCHEMISTRY

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent

(2012) Sharifah S. Syed Alwi et al.   CELL STRESS & CHAPERONES

New lysine methyltransferase drug targets in cancer

(2012) Tobias Wagner et al.   NATURE BIOTECHNOLOGY

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

(2011) Fen Yang et al.   EMBO JOURNAL

A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms

(2011) Shahram Golbabapour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Benzyl Isothiocyanate (BITC) Induces G2/M Phase Arrest and Apoptosis in Human Melanoma A375.S2 Cells through Reactive Oxygen Species (ROS) and both Mitochondria-Dependent and Death Receptor-Mediated Multiple Signaling Pathways

(2011) Su-Hua Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Selective Depletion of Mutant p53 by Cancer Chemopreventive Isothiocyanates and Their Structure−Activity Relationships

(2011) Xiantao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study

(2011) Mitali Pandey et al.   MOLECULAR CARCINOGENESIS

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

(2011) Dominique Ziech et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)

(2011) Xiangyu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer

(2010) Shahana Majid et al.   CANCER

HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1

(2010) Lina Pan et al.   Cellular & Molecular Immunology

The role of epigenetics in environmental and occupational carcinogenesis

(2010) Dominique Ziech et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704

(2010) Ananya Manuyakorn et al.   JOURNAL OF CLINICAL ONCOLOGY

Benzyl Isothiocyanate-Mediated Inhibition of Histone Deacetylase Leads to NF- B Turnoff in Human Pancreatic Carcinoma Cells

(2010) S. Batra et al.   MOLECULAR CANCER THERAPEUTICS

Differential Response of Normal (PrEC) and Cancerous Human Prostate Cells (PC-3) to Phenethyl Isothiocyanate-Mediated Changes in Expression of Antioxidant Defense Genes

(2010) Anna A. Powolny et al.   PHARMACEUTICAL RESEARCH

Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

(2009) S. E. Elsheikh et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

Oxidative stress, DNA methylation and carcinogenesis

(2008) Rodrigo Franco et al.   CANCER LETTERS

Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo

(2008) Julia K. Kurash et al.   MOLECULAR CELL

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b

(2008) Jin He et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY