Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

(2022) Bilal Rah et al.   Frontiers in Pharmacology

HMGB1 enhances chemotherapy resistance in multiple myeloma cells by activating the nuclear factor-κB pathway

(2021) Jing Ning et al.   Experimental and Therapeutic Medicine

Co-evolution of tumor and immune cells during progression of multiple myeloma

(2021) Ruiyang Liu et al.   Nature Communications

Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway

(2020) Abdul Q. Khan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple Myeloma: Available Therapies and Causes of Drug Resistance

(2020) Vanessa Pinto et al.   Cancers

JAK-STAT Signalling Pathway in Cancer

(2020) Andrew J. Brooks et al.   Cancers

Haematology: multiple myeloma

(2019) et al.   CLINICAL MEDICINE

Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma

(2019) Danielle Harmer et al.   Frontiers in Endocrinology

STAT3: A Promising Therapeutic Target in Multiple Myeloma

(2019) Chong et al.   Cancers

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

(2019) Sabah Akhtar et al.   Frontiers in Oncology

The regulation of JAKs in cytokine signaling and its breakdown in disease

(2018) Henrik M. Hammarén et al.   CYTOKINE

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines

(2018) Kirti S. Prabhu et al.   Frontiers in Pharmacology

HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair

(2018) Xing Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases

(2018) Ajaikumar B. Kunnumakkara et al.   Frontiers in Pharmacology

Potential therapeutic targets of Guggulsterone in cancer

(2017) Ajaz A. Bhat et al.   Nutrition & Metabolism

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

(2017) Kirti S. Prabhu et al.   PLoS One

Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells

(2016) Ahmad Iskandarani et al.   Journal of Translational Medicine

The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations

(2016) Jessica L. Geiger et al.   ORAL ONCOLOGY

HMGB1 as biomarker and drug target

(2016) Emilie Venereau et al.   PHARMACOLOGICAL RESEARCH

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway

(2015) Juan-Juan Shi   WORLD JOURNAL OF GASTROENTEROLOGY

Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression

(2015) FEI ZHONG et al.   Oncology Letters

Overcoming bortezomib resistance in multiple myeloma

(2014) Megan Y. Murray et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive Oxygen Species-Mediated Activation of AMP-Activated Protein Kinase and c-Jun N-terminal Kinase Plays a Critical Role in Beta-Sitosterol-Induced Apoptosis in Multiple Myeloma U266 cells

(2013) Song Hyo Sook et al.   PHYTOTHERAPY RESEARCH

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells

(2011) Sora Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Signal transducer and activator of transcription 3 pathway mediates genipin-induced apoptosis in U266 multiple myeloma cells

(2011) Jang Choon Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

High-mobility group box 1 and cancer

(2010) Daolin Tang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

(2010) Feng Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells

(2010) Sun-Hee Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3

(2009) Rebecca J. Leeman-Neill et al.   CARCINOGENESIS

Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death

(2009) C. Li et al.   MOLECULAR CANCER THERAPEUTICS

Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1

(2008) K. S. Ahn et al.   CANCER RESEARCH

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

(2008) Jerry E. Chipuk et al.   TRENDS IN CELL BIOLOGY