Review
Oncology
Abedul Haque, Daniel Brazeau, Arm R. Amin
Summary: Although cancer is the second deadliest disease worldwide, recent advances in precision treatments are promising. However, challenges remain due to the heterogeneity and mutational burdens of cancer cells. Chemoprevention, especially with natural dietary compounds, is considered a rational and appealing strategy to prevent carcinogenesis, particularly in high-risk populations.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Mariia Zadorozhna, Domenica Mangieri
Summary: Ginger, a commonly used spice and medicinal plant, exhibits anti-inflammatory, antioxidant, and anti-tumor properties. Recent studies have shown that ginger extracts have chemopreventive characteristics against cancer by disrupting crucial processes such as cell survival, proliferation, and dissemination of cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Seyed Mohammad Ali Mirazimi, Fatemeh Dashti, Mohammad Tobeiha, Ali Shahini, Raha Jafari, Mehrad Khoddami, Amir Hossein Sheida, Parastoo EsnaAshari, Amir Hossein Aflatoonian, Fateme Elikaii, Melika Sadat Zakeri, Michael R. Hamblin, Mohammad Aghajani, Minoodokht Bavarsadkarimi, Hamed Mirzaei
Summary: This article summarizes the therapeutic effects of quercetin in gastrointestinal cancers, including pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral cancers. Quercetin inhibits tumor progression by regulating the cell cycle and apoptosis, as well as through its antioxidant properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Materials Science, Biomaterials
Zhenjie Yin, Bingyong You, Yuanyuan Bai, Yu Zhao, Shangfan Liao, Yingming Sun, Yongyang Wu
Summary: Renal cell carcinoma (RCC) represents the majority of malignant kidney cancers, and there has been substantial progress in therapeutic options for RCC in the past decade. Targeted therapy and immunotherapy have revolutionized RCC treatment and improved outcomes; however, adverse effects and drug resistance remain significant challenges. Natural compounds have gained attention as alternative strategies due to their tolerability and cost-effectiveness. Numerous studies have investigated the anti-RCC activity of natural products and identified potential mechanisms. This article provides a review on the chemoprevention and therapeutic potential of natural compounds, as well as explores their underlying mechanisms.
Review
Nutrition & Dietetics
Asma Ismail Mahmod, Shatha Khaled Haif, Ayah Kamal, Israa A. Al-ataby, Wamidh H. Talib
Summary: This review aims to explore the anti-inflammatory and anti-colorectal cancer potential of natural bioactive compounds derived from the main foods in the Mediterranean diet.
FRONTIERS IN NUTRITION
(2022)
Review
Oncology
Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Summary: The MAPK pathway plays a crucial role in transmitting signals from outside the cell to inside, and is associated with cancer treatment response, normal cell pathway maintenance, and compensatory pathway activation. MAPK inhibitors often activate compensatory feedback loops, leading to resistance in tumor cells and microenvironment. Therefore, innovative combination therapies are needed to limit alternate pathway initiation.
CANCER CELL INTERNATIONAL
(2022)
Review
Medicine, Research & Experimental
Mehrdad Hashemi, Sepideh Mirzaei, Maryamsadat Barati, Elahe Sadat Hejazi, Amirabbas Kakavand, Maliheh Entezari, Shokooh Salimimoghadam, Alireza Kalbasi, Mohsen Rashidi, Afshin Taheriazam, Gautam Sethi
Summary: Curcumin has shown beneficial effects in the treatment of urological cancers by inducing apoptosis, suppressing metastasis and invasion, and interfering with cancer progression through inhibition of MMPs. Its synergistic effects when used in combination with chemotherapy agents make it a potential chemosensitizer.
Article
Chemistry, Physical
Sravan Kumar Miryala, Soumya Basu, Aniket Naha, Reetika Debroy, Sudha Ramaiah, Anand Anbarasu, Saravanan Natarajan
Summary: The study selected 15 natural compounds to explore their anti-tuberculosis properties through in-silico approaches, and found that Glycyrrhizin, Swertiamarin, and Laccaic acid showed better binding affinity than classical anti-tuberculosis drugs, indicating their potential as multi-target specific alternative drug candidates.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Oncology
Ricardo Lagoa, Dorinda Marques-da-Silva, Mario Diniz, Maria Daglia, Anupam Bishayee
Summary: This article discusses the effects of environmental toxicants on health, focusing on their impact on cell redox and calcium homeostasis, mitochondria, and inflammatory signaling. The potential of plant-derived polyphenols in reducing cancer incidence and mitigating the detrimental effects of harmful pollutants is also explored.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesca Gado, Maria Digiacomo, Jasmine Esposito Salsano, Marco Macchia, Clementina Manera
Summary: This review discusses the effects of phenolic compounds on non-melanoma skin cancer (NMSC) and melanoma (MM), showing their potential in preventing and treating these tumors. Phenols can induce photoprotection, apoptosis and autophagy, while reducing DNA methylation, tumorigenesis and tumor proliferation. Plant extracts with anticancer activity may be more effective than single phenols.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Abdelhakim Bouyahya, Naoufal El Hachlafi, Tarik Aanniz, Ilhame Bourais, Hamza Mechchate, Taoufiq Benali, Mohammad Ali Shariati, Pavel Burkov, Jose M. Lorenzo, Polrat Wilairatana, Mohammad S. Mubarak, Nasreddine El Omari
Summary: Cancer is a complex pathology that can be caused by various risk factors, including epigenetic factors. Natural molecules extracted from medicinal plants have been found to inhibit the enzymatic activity of histone deacetylases (HDACs), showing potential as anti-cancer agents.
Review
Biochemistry & Molecular Biology
Mi Eun Kim, Dae Hyun Kim, Jun Sik Lee
Summary: Inflammation exacerbates systemic pathophysiological conditions and chronic inflammation is a sustained and systemic phenomenon that aggravates aging that can lead to chronic age-related diseases. The accumulation and mechanisms of SIRT1, NF-kappa B, and FoxO-mediated inflammatory processes and cellular proinflammatory signaling pathways are described. The proinflammatory mechanisms underlying metabolic molecular pathways in various diseases such as liver cancer and diabetes are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Baoyi Ni, Xiaotong Song, Bolun Shi, Jia Wang, Qianhui Sun, Xinmiao Wang, Manman Xu, Luchang Cao, Guanghui Zhu, Jie Li
Summary: Cancer is a major cause of human death, and the use of anticancer drugs is limited. Many natural products, including ginseng, have low toxicity and can effectively treat gastrointestinal tumors.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Mahshad Sarvizadeh, Omid Hasanpour, Zari Naderi Ghale-Noie, Samaneh Mollazadeh, Mohammad Rezaei, Hossein Pourghadamyari, Mohammadjaber Masoud Khooy, Michael Aschner, Haroon Khan, Nima Rezaei, Layla Shojaie, Hamed Mirzaei
Summary: Allicin, a key compound in garlic, has shown various benefits including anti-inflammatory and anticancer effects, which can lower the risk of digestive system cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jian Gao, Zuojing Yin, Zhuanbin Wu, Zhen Sheng, Chao Ma, Rui Chen, Xiongwen Zhang, Kailin Tang, Jian Fei, Zhiwei Cao
Summary: This study explored the synergistic effects of Berberine and Evodiamine in hepatocellular carcinoma by co-inhibiting NF-kappa B and c-JUN, which showed significant anticancer activity. The in vivo experiments in zebrafish and analysis of HCC individuals revealed promising results, suggesting the potential of natural compounds for developing combination therapies in combating malignant cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Muzaffar Ahmad Malla, Mir Samiullah, Ajaz Ahmad Bhat, Munir Farooq
Summary: The present study evaluated the mini-open carpal tunnel release surgery on 25 patients and found significant improvement in symptom severity scores and functional status scores. The average sensory conduction velocity increased at 6 months postoperative, and there were very few complications.
INDIAN JOURNAL OF SURGERY
(2023)
Review
Chemistry, Multidisciplinary
Takwa Bedhiafi, Sourour Idoudi, Areej Ali Alhams, Queenie Fernandes, Heba Iqbal, Renuka Basineni, Shahab Uddin, Said Dermime, Maysaloun Merhi, Nashiru Billa
Summary: Polydopamine (PDA) is a biopolymer with unique physicochemical properties and has various applications in drug delivery, biosensing, imaging, and cancer therapy. Recent research has discovered the potential of PDA as a coating material for mucosal drug delivery, but there is limited information on this application. This review presents the properties of PDA and its biomedical applications, with a focus on its role as a coating material for nanoparticulate carriers in mucosal drug delivery. The challenges and possibilities of translating this technology to clinical studies are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Ikhlak Ahmed, Mubarak Ziab, Sahar Da'as, Waseem Hasan, Sujitha P. Jeya, Elbay Aliyev, Sabah Nisar, Ajaz A. Bhat, Khalid Adnan Fakhro, Ammira S. Alshabeeb Akil
Summary: Diabetic nephropathy (DN) is a common microvascular complication of diabetes that leads to end-stage renal disease. This study aimed to identify key transcription factors (TFs) associated with DN progression by performing a meta-analysis on gene expression profiles from multiple datasets. The analysis revealed distinct clusters of dysregulated susceptibility genes in different renal compartments, with a subset of these genes encoding critical TFs involved in DN development and podocyte function. The role of these TFs was validated in a hyperglycemic zebrafish model, showing that altered expression of these genes leads to morphological abnormalities in various kidney structures. This study provides insights into the molecular drivers, essential genes, and pathways involved in DN initiation and development.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Multidisciplinary Sciences
Munazza Tamkeen Fatima, Ajaz Ahmad Bhat, Sabah Nisar, Khalid Adnan Fakhro, Ammira Sarah Al-Shabeeb Akil
Summary: A healthy diet is crucial for cellular health and oxidative stress plays a significant role in various diseases. Antioxidants, found in dietary foods such as tea, coffee, wine, oils, and honey, can reduce oxidative stress and combat type 2 diabetes and neurodegenerative disorders.
Review
Medicine, Research & Experimental
Ajay Vikram Singh, Vaisali Chandrasekar, Namuna Paudel, Peter Laux, Andreas Luch, Donato Gemmati, Veronica Tisato, Kirti S. Prabhu, Shahab Uddin, Sarada Prasad Dakua
Summary: More information about genetic makeup, drug response, multi-omics response, and genomic response is now available, leading to personalized treatment. Non-animal testing and computational toxicogenomics are becoming integral parts of risk assessment. Artificial intelligence (AI) has the potential to analyze patient data, predict treatment outcomes, and expedite data processing in personalized medicine and toxicogenomics. This article explores the current trends, future perspectives, challenges, and limitations in personalized medicine, toxicogenomics, and AI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pathology
Sehrish Sarwar Baloch, Saqib Raza Khan, Muhammad Tariq, Abdul Wasio, Ayesha Arshad Ali, Mehwish Shahzadi, Munira Moosajee, Shaheena Anwar, Afsheen Raza, Shahab Uddin
Summary: Paraneoplastic syndromes are complex clinical manifestations caused by hormones, cytokines, peptides or antibodies produced by malignant cells in the underlying malignancy, affecting multiple organ systems. Multiple Myeloma (MM), accounting for 10-15% of hematological malignancies and 1-2% of all malignancies, is associated with atypical clinical and laboratory paraneoplastic manifestations. Understanding these manifestations is important for differential diagnosis in uncertain cases.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Reem Khaled M. E. Alsayed, Khalid Sultan A. M. Sheikhan, Majid Ali Alam, Jorg Buddenkotte, Martin Steinhoff, Shahab Uddin, Aamir Ahmad
Summary: Cancer 'stemness' is crucial for the existence and characteristics of cancer cells. Transcription factors such as NF-KB and STAT-3 play a significant role in cancer stemness and are potential targets for cancer therapy. The study of non-coding RNAs has revealed their interactions with these transcription factors, offering insights into the regulatory mechanisms of cancer stemness and potential therapeutic opportunities.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Cell & Tissue Engineering
Arshi Waseem, Abdul Quaiyoom Khan, Mohsin Ali Khan, Rehan Khan, Shahab Uddin, Johannes Boltze, Syed Shadab Raza
Summary: Stroke is a leading cause of death and disability worldwide, but effective treatments are limited. Abnormal expression of various non-coding RNAs (ncRNAs) has been found after stroke, affecting processes such as neurogenesis, angiogenesis, apoptosis, and autophagy. Understanding the roles and mechanisms of ncRNAs holds promise for future stroke treatments, as they can modify the impact and progression of stroke on a molecular level. Exploring the functions and underlying mechanisms of ncRNAs after stroke may reveal new therapeutic targets and improve diagnostics for stroke.
Article
Multidisciplinary Sciences
A. . A. . Bhat, Sheikh P. Ahmad, Ehab M. Almetwally, Nagla Yehia, Najwan Alsadat, Ahlam H. Tolba
Summary: In this paper, the authors propose and investigate the odd Lindley Power Rayleigh (OLPR) distribution, which combines the odd Lindley-G family and power Rayleigh distribution. The proposed distribution offers greater flexibility than some well-known extensions, such as the Lindley and Rayleigh distributions. The paper provides a comprehensive analysis of the mathematical and statistical properties of the OLPR distribution, as well as estimation methods using classical and Bayesian approaches. Additionally, the authors conduct a simulation study to assess the performance of estimators based on biases and mean square errors, and demonstrate the superiority of the proposed model in practical real-life applications using various goodness-of-fit measures.
SCIENTIFIC AFRICAN
(2023)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Cell Biology
Sourour Idoudi, Takwa Bedhiafi, Shona Pedersen, Mohamed Elahtem, Izzaldin Alremawi, Sabah Akhtar, Said Dermime, Maysaloun Merhi, Shahab Uddin
Summary: This review focuses on the role of HMGB1 in human malignancies and the signaling pathways associated with it. It also discusses the potential of HMGB1 as a target/biomarker for cancer therapy, as well as the therapeutic strategies used to target HMGB1.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Queenie Fernandes, Lubna Therachiyil, Abdul Q. Khan, Takwa Bedhiafi, Hesham M. Korashy, Ajaz A. Bhat, Shahab Uddin
Summary: Cancer is a major cause of death worldwide and current treatments have limited efficacy. Nanotechnology offers innovative solutions by leveraging the unique properties of nanomaterials, improving drug efficiency, reducing side effects, and targeting cancer stem cells. However, there are still challenges in obtaining clinical approval for nano-drugs.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Oncology
Shirin Azizidoost, Farhoodeh Ghaedrahmati, Mohadeseh Sheykhi-Sabzehpoush, Shahab Uddin, Mehri Ghafourian, Abdolah Mousavi Salehi, Mona Keivan, Maryam Cheraghzadeh, Zahra Nazeri, Maryam Farzaneh, Seyed Esmaeil Khoshnam
Summary: MCM3AP-AS1, a long noncoding RNA, is implicated in the progression of several types of cancers by targeting various signaling pathways and microRNAs associated with cancer development.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
