Article
Oncology
Hui Yi, Long Liang, Haiqin Wang, Saiqun Luo, Lei Hu, Yanpeng Wang, Xiaokai Shen, Ling Xiao, Yibin Zhang, Hongling Peng, Chongwen Dai, Lingli Yuan, Ruijuan Li, Fanjie Gong, Zhenzhen Li, Mao Ye, Jing Liu, Hui Zhou, Ji Zhang, Xiaojuan Xiao
Summary: This study demonstrates the potential therapeutic effects of albendazole on multiple myeloma by inhibiting MM cell proliferation, reducing the number of MMSCs, and eliminating drug resistance induced by MMSCs through the inhibition of the NF-KB pathway.
Article
Medicine, Research & Experimental
Yu Feng, Jingcao Huang, Fangfang Wang, Zhimei Lin, Hongmei Luo, Qian Li, Xin Wang, Xiang Liu, Xinyu Zhai, Qianwen Gao, Lingfeng Li, Yue Zhang, Jingjing Wen, Li Zhang, Ting Niu, Yuhuan Zheng
Summary: The study revealed that high MCCA expression in patients with MM led to improved overall survival. Knockdown of MCCA in MM cells resulted in increased survival rates after treatment with different anti-MM drugs. Mechanistic studies showed dysfunctional mitochondria in MCCA-KD cells and protein-protein interactions between MCCA and Bad. Additionally, MCCA was found to contribute to multidrug resistance in various human cancers.
Article
Biochemistry & Molecular Biology
Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Shiori Seki, Yoshika Tomonari, Shoutaro Koizumi, Miki Nagatakiya, Mai Katsuyama, Yuuta Yamamoto, Katsumasa Tsurushima, Toshihiko Ishizaka, Shozo Nishida
Summary: This study reveals different mechanisms of resistance to bortezomib and ixazomib in multiple myeloma cell lines, with high expression levels of SGK1 and NF-kappa B p65 associated with low sensitivity to bortezomib and poor prognosis. Combining bortezomib and ixazomib with SGK1 or NF-kappa B inhibitors may enhance their efficacy in multiple myeloma treatment.
Article
Oncology
Zhenzhen Li, Haiqin Wang, Yanpeng Wang, Zekang Ma, Lei Hu, Saiqun Luo, Yanfei Gong, Lin Zhu, Han Gong, Ruohong Xiang, Yu Zhu, Yifang Xie, Chaoying Yang, Hongling Peng, Jing Liu, Xiaojuan Xiao
Summary: Multiple myeloma stem-like cells (MMSCs) contribute to drug resistance and relapse in multiple myeloma (MM). In this study, luteolin (LUT), a natural compound obtained from various plants, was found to effectively inhibit MM cell proliferation and overcome bortezomib (BTZ) resistance by decreasing the proportion of ALDH1(+) cells. RNA sequencing revealed that LUT inhibited transforming growth factor-beta signaling. LUT also reduced ALDH1(+) cell proportion in primary CD138+ plasma cells and synergistically enhanced the anti-myeloma effect of BTZ. These findings highlight LUT as a potential therapeutic agent for targeting MMSCs and overcoming drug resistance.
Review
Biochemistry & Molecular Biology
S. Rajeev Krishnan, M. Bebawy
Summary: A major obstacle in cancer treatment is the development of drug resistance, particularly multidrug resistance (MDR), which refers to cross resistance to multiple drugs. One mechanism of MDR is the transfer of resistance proteins and nucleic acids through extracellular vesicles, specifically microparticles (MPs). This review focuses on the potential of MPs as novel clinical biomarkers for the early detection of MDR in multiple myeloma (MM).
Article
Plant Sciences
Noemie Saraux, Deniza Imeri, Luis Quiros-Guerrero, Soumana Karimou, Philippe Christen, Muriel Cuendet
Summary: Ipomoea asarifolia, a herbaceous plant from the Convolvulaceae family, has shown antiproliferative activity against multiple myeloma cells. A total of 15 compounds were isolated from the plant, with compound 3 demonstrating the most potent activity with an IC50 value of 3.0 μM against RPMI 8226 cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Mailee Huynh, Hae Yeun Chang, Dominique N. Lisiero, Irene M. Ong, Trinayan Kashyap, Natalie S. Callander, Shigeki Miyamoto
Summary: This study identifies HAPLN1 as an extracellular matrix factor that can confer multiple drug resistance to multiple myeloma cells.
Article
Chemistry, Applied
Deepa Swati Lakra, B. Pradhapsingh, N. Deepika, T. Dhanalakshmi, G. Kanimozhi, Rajendra N. Prasad
Summary: This study evaluated the chemosensitizing property of Andro in P-gp overexpressing multidrug-resistant (MDR) colchicine-selected KBCh(R) 8-5 cells. Molecular docking studies showed Andro exhibits higher binding interaction with P-gp than other studied transporters. Furthermore, Andro downregulates P-gp overexpression via NF-kappa B signaling in MDR cell lines and enhances the therapeutic effect of PTX in drug-resistant cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Cell Biology
Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong
Summary: This study demonstrated that scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB signaling pathway, with the most significant effect observed at high doses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Rudra Prasad Dutta, Rohit Kumar, Prashant R. Tembhare, Bhausaheb Bagal, Rajeeb Kumar Swain, Syed Khizer Hasan
Summary: This study investigated the efficacy of THZ1, a covalent CDK7 inhibitor, in the treatment of multiple myeloma (MM). THZ1 showed anti-myeloma activity in MM models but had no effect on healthy CD34+ cells. It suppressed phosphorylation of RNA polymerase II carboxy-terminal domain and downregulated the transcription of BCL2 family of proteins, leading to G1/S arrest and apoptosis in MM cells.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianping Li, Ampon Sae Her, Nathaniel J. Traaseth
Summary: EmrE is a multidrug efflux pump in Escherichia coli that transports drugs as a homodimer using energy from the proton motive force. Research suggests that the two Glu14 residues in the dimer have independent pKa values and are not electrostatically coupled, supporting a transport pathway with well-defined protonation states in each monomer of the dimer. The findings also propose a model, hop-free exchange, for how exchangers with conformation-dependent pKa values reduce proton leakage, relevant to the SMR family and transporters with inverted repeat domains.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Thomas A. Burley, Emma Kennedy, Georgia Broad, Melanie Boyd, David Li, Timothy Woo, Christopher West, Eleni E. Ladikou, Iona Ashworth, Christopher Fegan, Rosalynd Johnston, Simon Mitchell, Simon P. Mackay, Andrea G. S. Pepper, Chris Pepper
Summary: In this study, the researchers evaluated the effects of an NF-kappa B inducing kinase (NIK) inhibitor, CW15337, on primary chronic lymphocytic leukemia (CLL) cells, CLL and multiple myeloma (MM) cell lines, and normal B- and T-lymphocytes. They found that CW15337 induced apoptosis and inhibited the non-canonical NF-kappa B signaling pathway, reversing BCL2 family-mediated resistance. The combination of CW15337 with fludarabine or ABT-199 showed synergistic cytotoxic effects.
Review
Oncology
Hamed Mirzaei, Hossein Bagheri, Faezeh Ghasemi, Jaber M. Khoi, Mohammad H. Pourhanifeh, Yvan Heyden, Erfan Mortezapour, Ali Nikdasti, Philippe Jeandet, Haroon Khan, Amirhossein Sahebkar
Summary: Multiple Myeloma (MM) is a common and deadly hematological malignancy characterized by monoclonal proliferation within bone marrow. Curcumin, an active compound from turmeric, has shown promising effects in inhibiting cancer cell growth and preventing drug resistance in MM. Despite improvements in therapeutic strategies, MM remains incurable, but curcumin offers potential as a natural treatment option.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Gabriele Sani, Stella Margoni, Andrea Brugnami, Ottavia Marianna Ferrara, Evelina Bernardi, Alessio Simonetti, Laura Monti, Marianna Mazza, Delfina Janiri, Lorenzo Moccia, Georgios D. Kotzalidis, Daniela Pia Rosaria Chieffo, Luigi Janiri
Summary: There is growing interest in the involvement of antioxidative systems, particularly Nrf2, in protecting against depression. Through a PubMed search, 89 eligible articles out of 208 results were identified. These studies suggest that Nrf2 is lower in depression and that antidepressant methods can increase its levels.
Review
Oncology
Lukas John, Maria Theresa Krauth, Klaus Podar, Marc-Steffen Raab
Summary: Multiple Myeloma is a cancer of plasma cells in the bone marrow. Pathway-directed therapy combined with personalized medicine can improve treatment outcomes. Targeting specific signaling pathways and conducting precision medicine trials may fundamentally change treatment strategies for Multiple Myeloma.
