Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells

The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2

(2015) Azfar Jamal et al.   CELL CYCLE

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model

(2015) Kodappully Sivaraman Siveen et al.   Oncotarget

E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma

(2015) Jing Wang et al.   Oncotarget

The ubiquitin proteasome system — Implications for cell cycle control and the targeted treatment of cancer

(2013) Florian Bassermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential

(2013) Yu-Feng Tian et al.   TUMOR BIOLOGY

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Apigenin induces apoptosisviadownregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells

(2010) A. R. Hussain et al.   CELL PROLIFERATION

Skp2 knockout reduces cell proliferation and mouse body size: and prevents cancer?

(2010) Liang Zhu   CELL RESEARCH

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer

(2009) Shahab Uddin et al.   LABORATORY INVESTIGATION

Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells

(2009) Azhar R. Hussain et al.   LEUKEMIA & LYMPHOMA

Imatinib Mesylate Induces Quiescence in Gastrointestinal Stromal Tumor Cells through the CDH1-SKP2-p27Kip1Signaling Axis

(2008) Ying Liu et al.   CANCER RESEARCH

Bortezomib (Velcade) Induces p27Kip1 Expression through S-Phase Kinase Protein 2 Degradation in Colorectal Cancer

(2008) S. Uddin et al.   CANCER RESEARCH

S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma

(2008) S Uddin et al.   JOURNAL OF PATHOLOGY