Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology

Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection

(2022) Kengo Nozaki et al.   Annual Review of Immunology

A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model

(2022) Murali Vijayan et al.   AGING CELL

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

(2022) Hongxu Xian et al.   IMMUNITY

Reduced VDAC1, Maintained Mitochondrial Dynamics and Enhanced Mitochondrial Biogenesis in a Transgenic Tau Mouse Model of Alzheimer’s Disease

(2022) Murali Vijayan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpressed VDAC1 in breast cancer as a novel prognostic biomarker and correlates with immune infiltrates

(2022) Yutong Fang et al.   World Journal of Surgical Oncology

Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models

(2021) Marina Trombetta-Lima et al.   CELL CALCIUM

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

(2021) Elizabeth A. Thompson et al.   Cell Reports

A Systematic Review of Glucose Transport Alterations in Alzheimer's Disease

(2021) Natalia Kyrtata et al.   Frontiers in Neuroscience

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

(2021) Ana Belen Lopez‐Rodriguez et al.   Alzheimers & Dementia

Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury

(2021) Baolin Niu et al.   CELL BIOLOGY AND TOXICOLOGY

Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease

(2021) Kumari Preeti et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

(2021) Mariana Van Zeller et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target

(2021) Ankit Verma et al.   MOLECULAR THERAPY

Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model

(2021) Moonseok Choi et al.   Molecular Brain

FORTIS: a live-cell assay to monitor AMPA receptors using pH-sensitive fluorescence tags

(2021) María Calleja-Felipe et al.   Translational Psychiatry

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

New Insights Into the Pathogenesis of Alzheimer's Disease

(2020) Liyuan Fan et al.   Frontiers in Neurology

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Glucose transporters in brain in health and disease

(2020) Hermann Koepsell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism

(2020) Hadar Klapper-Goldstein et al.   Scientific Reports

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance

(2019) Rui-Yuan Pan et al.   Science Advances

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

(2019) Niraj Kumar Jha et al.   JOURNAL OF NEUROCHEMISTRY

The role of mitochondrial defects and oxidative stress in Alzheimer’s disease

(2019) Badar ul Islam et al.   JOURNAL OF DRUG TARGETING

Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia

(2019) Shun-Ming Ting et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease

(2019) Yuan Zhang et al.   Frontiers in Cellular Neuroscience

A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS

(2019) Anna Shteinfer-Kuzmine et al.   Frontiers in Cellular Neuroscience

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

(2019) Giovanna Cenini et al.   Frontiers in Pharmacology

Mitochondrial Transfer Ameliorates Cognitive Deficits, Neuronal Loss, and Gliosis in Alzheimer’s Disease Mice

(2019) Keren Nitzan et al.   JOURNAL OF ALZHEIMERS DISEASE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Expression and Functions of Cellular Prion Proteins in Immunocytes

(2019) Baizhuo Zhang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury

(2019) Vera Paschon et al.   Scientific Reports

Systemic and central nervous system metabolic alterations in Alzheimer’s disease

(2019) Vera van der Velpen et al.   Alzheimers Research & Therapy

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Tar get for Modulating Apoptosis

(2018) Varda Shoshan-Barmatz et al.   CURRENT MEDICINAL CHEMISTRY

Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies

(2018) Ralph N. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

(2018) IsaacG Onyango   Neural Regeneration Research

VDAC1, mitochondrial dysfunction, and Alzheimer's disease

(2018) Varda Shoshan-Barmatz et al.   PHARMACOLOGICAL RESEARCH

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

(2018) Shaoming Sang et al.   Alzheimers Research & Therapy

Enhanced Expression of the Voltage-Dependent Anion Channel 1 (VDAC1) in Alzheimer's Disease Transgenic Mice: An Insight into the Pathogenic Effects of Amyloid-β

(2018) Mar Cuadrado-Tejedor et al.   JOURNAL OF ALZHEIMERS DISEASE

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

(2018) Elena Radi et al.   JOURNAL OF ALZHEIMERS DISEASE

An Integrative Overview of Non-Amyloid and Non-Tau Pathologies in Alzheimer’s Disease

(2018) Blaise W. Menta et al.   NEUROCHEMICAL RESEARCH

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

(2018) Enming Zhang et al.   Cell Metabolism

Central role of RIPK1-VDAC1 pathway on cardiac impairment in a non-human primate model of rheumatoid arthritis

(2018) Fanxin Zeng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

Differentially Severe Cognitive Effects of Compromised Cerebral Blood Flow in Aged Mice: Association with Myelin Degradation and Microglia Activation

(2017) Gilly Wolf et al.   Frontiers in Aging Neuroscience

Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans

(2017) Simon Vann Jones et al.   Frontiers in Immunology

Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Glucose Transporters in Brain: In Health and in Alzheimer’s Disease

(2016) Leszek Szablewski   JOURNAL OF ALZHEIMERS DISEASE

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

(2016) Danya Ben-Hail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

(2016) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

(2016) Shira Knafo et al.   NATURE NEUROSCIENCE

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease

(2016) Wanda M. Snow et al.   Frontiers in Molecular Neuroscience

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4

(2015) Inhwa Hwang et al.   IMMUNOLOGY AND CELL BIOLOGY

The Voltage-dependent Anion Channel 1 Mediates Amyloid β Toxicity and Represents a Potential Target for Alzheimer Disease Therapy

(2015) Angela Smilansky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

(2015) Mikhail A. Kostylev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Spatial cognitive deficits in an animal model of Wernicke–Korsakoff syndrome are related to changes in thalamic VDAC protein concentrations

(2015) K.O. Bueno et al.   NEUROSCIENCE

Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease

(2014) Michael A Castello et al.   BMC Neurology

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

(2013) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

Amylin: what might be its role in Alzheimer’s disease and how could this affect therapy?

(2013) Florin Despa et al.   Expert Review of Proteomics

Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors

(2013) Hsu-Wen Chao et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage

(2013) Isobel J. Whitehouse et al.   PLoS One

Glutamine Synthetase as an Astrocytic Marker: Its Cell Type and Vesicle Localization

(2013) Enrico Anlauf et al.   Frontiers in Endocrinology

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease

(2012) Gunter P. Eckert et al.   MOLECULAR NEUROBIOLOGY

VDAC1: from structure to cancer therapy

(2012) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif

(2011) Bryan Maloney et al.   GENE

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

(2011) Latha Devi et al.   NEUROBIOLOGY OF DISEASE

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

(2010) N. Keinan et al.   MOLECULAR AND CELLULAR BIOLOGY

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Microglia in the aging brain: relevance to neurodegeneration

(2010) Xiao-Guang Luo et al.   Molecular Neurodegeneration

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Aβ and human amylin share a common toxicity pathwayviamitochondrial dysfunction

(2010) Yun-An Lim et al.   PROTEOMICS

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

(2008) Sonja Wolff et al.   CELL RESEARCH

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics

(2008) Hanna Rosenmann et al.   EXPERIMENTAL NEUROLOGY

Hexokinase-I Protection against Apoptotic Cell Death Is Mediated via Interaction with the Voltage-dependent Anion Channel-1

(2008) Salah Abu-Hamad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON