New Insights Into the Pathogenesis of Alzheimer's Disease

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

(2019) Cristina Vergara et al.   ACTA NEUROPATHOLOGICA

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition

(2019) Anthony J. Martorell et al.   CELL

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

(2019) Chinnakkaruppan Adaikkan et al.   NEURON

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

(2019) Dylan Shea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain

(2019) Atsushi Aoyagi et al.   Science Translational Medicine

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

(2019) Jing Tian et al.   Science Translational Medicine

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Chronic ghrelin administration restores hippocampal long-term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease

(2018) Maryam Eslami et al.   HIPPOCAMPUS

MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease

(2018) Yu-on Jeong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells

(2018) Raquel Coronel et al.   MOLECULAR NEUROBIOLOGY

Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease

(2018) Carlo Condello et al.   NEUROBIOLOGY OF DISEASE

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference

(2018) Ted M. Hsu et al.   NEUROPHARMACOLOGY

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

(2018) Claudia Jara et al.   Redox Biology

Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired Hippocampal Neurogenesis and its Enhancement with Ghrelin in 5XFAD Mice

(2018) Minho Moon et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

(2018) Yifan Wu et al.   Nature Communications

Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease

(2017) Alexandra J. Mably et al.   HIPPOCAMPUS

Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis

(2017) Taro Kishi et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization

(2017) Rui Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Merck ends trial of potential Alzheimer’s drug verubecestat

(2017) Nigel Hawkes   BMJ-British Medical Journal

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Merck ends trial of potential Alzheimer’s drug verubecestat

(2017) Nigel Hawkes   BMJ-British Medical Journal

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines

(2017) Amanda L. Woerman et al.   JAMA Neurology

Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy

(2016) C. A. Booth et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples

(2016) Anna K. Gillespie et al.   NEURON

Physiological and Pathophysiological Implications of Synaptic Tau

(2016) Philip Regan et al.   NEUROSCIENTIST

Genes associated with Alzheimer's disease: an overview and current status

(2016) Mohan Giri et al.   Clinical Interventions in Aging

Tau: The Center of a Signaling Nexus in Alzheimer's Disease

(2016) Shahzad S. Khan et al.   Frontiers in Neuroscience

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor

(2015) Andras Kern et al.   CELL

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

Periodontal disease associates with higher brain amyloid load in normal elderly

(2015) Angela R. Kamer et al.   NEUROBIOLOGY OF AGING

Truncated tau deregulates synaptic markers in rat model for human tauopathy

(2015) Santosh Jadhav et al.   Frontiers in Cellular Neuroscience

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation

(2014) Yue Yin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

(2014) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Blocking the apoE/Aß interaction ameliorates Aß-related pathology in APOE ¿2 and ¿4 targeted replacement Alzheimer model mice

(2014) Joanna E Pankiewicz et al.   Acta Neuropathologica Communications

It cuts two ways: microtubule loss during Alzheimer disease

(2013) Daphney C Jean et al.   EMBO JOURNAL

Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer's disease

(2013) Romain Goutagny et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice

(2013) Suhail Rasool et al.   JOURNAL OF NEUROCHEMISTRY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

(2013) T. Kimura et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease

(2013) Mikko Hölttä et al.   PLoS One

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

(2013) E. Hudry et al.   Science Translational Medicine

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

(2012) D. M. Barten et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s disease: biological aspects, therapeutic perspectives and diagnostic tools

(2012) M Di Carlo et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Quantitative imaging of energy expenditure in human brain

(2012) Xiao-Hong Zhu et al.   NEUROIMAGE

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Genetics of Alzheimer's disease: new evidences for an old hypothesis?

(2011) Jean-Charles Lambert et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

(2011) Jens Brodbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Small moleculeβ-amyloid inhibitors that stabilize protofibrillar structuresin vitroimprove cognition and pathology in a mouse model of Alzheimer’s disease

(2010) Cheryl A. Hawkes et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Gamma Oscillations in the Hippocampus

(2010) Laura Lee Colgin et al.   PHYSIOLOGY

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

(2009) Matthew L. Hemming et al.   PLoS One

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE

Somatostatin and Alzheimer's disease

(2008) E. Burgos-Ramos et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Does memantine induce bradycardia? A study in the French PharmacoVigilance Database

(2008) Adeline Gallini et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE