Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics

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Gasdermin D in pyroptosis

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Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis

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Self‐Boosting Catalytic Nanoreactor Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis

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Hexahistidine-metal Assemblies: A Facile and Effective Co-delivery System of Subunit Vaccines for Potent Humoral and Cellular Immune Responses

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Gasdermin E suppresses tumour growth by activating anti-tumour immunity

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A bioorthogonal system reveals antitumour immune function of pyroptosis

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Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis

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Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment

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Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

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Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

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Decitabine/Cedazuridine: First Approval

(2020) Sohita Dhillon   DRUGS

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

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Hexahistidine-metal assemblies: A promising drug delivery system

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Caspase-1 initiates apoptosis in the absence of gasdermin D

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Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

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DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

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Decitabine in Combination with Donor Lymphocyte Infusions can Induce Remissions in relapsed Myeloid Malignancies with Higher Leukemic Burden after Allogeneic Hematopoietic Cell Transplantation

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

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Gasdermins: Effectors of Pyroptosis

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Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Digging deep into “dirty” drugs – modulation of the methylation machinery

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Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY