Emerging role of natural products in cancer immunotherapy

Overcoming hurdles in cancer immunotherapy

(2021) Ashley York   NATURE REVIEWS MICROBIOLOGY

Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model

(2020) Huan Xu et al.   BIOMATERIALS

Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer

(2020) Prachya Kongtawelert et al.   MOLECULES

Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

(2020) Yukun Huang et al.   Nature Communications

Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages

(2020) Jing He et al.   Drug Design Development and Therapy

Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin

(2020) Shuhui Zhang et al.   Frontiers in Pharmacology

A Potential Herbal Adjuvant Combined With a Peptide-Based Vaccine Acts Against HPV-Related Tumors Through Enhancing Effector and Memory T-Cell Immune Responses

(2020) Ying-Chyi Song et al.   Frontiers in Immunology

Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy

(2020) Zecong Xiao et al.   Science Advances

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds

(2020) Fabrizio Fontana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release

(2020) Wen Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes

(2020) Sixue Bi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells

(2020) Zhe Wang et al.   PHARMACOLOGICAL RESEARCH

MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ9-tetrahydrocannabinol and cannabidiol in human macrophages

(2020) John-Mark Fitzpatrick et al.   JOURNAL OF NEUROIMMUNOLOGY

Cancer immunotherapy comes of age and looks for maturity

(2020) Amanda Finck et al.   Nature Communications

Turning up the heat on non-immunoreactive tumours: opportunities for clinical development

(2020) María Ochoa de Olza et al.   LANCET ONCOLOGY

Targeting the epigenetic regulation of antitumour immunity

(2020) Simon J. Hogg et al.   NATURE REVIEWS DRUG DISCOVERY

Natural modulators of the hallmarks of immunogenic cell death

(2019) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Fucosylation enhances the efficacy of adoptively transferred antigen-specific cytotoxic T lymphocytes

(2019) Gheath Alatrash et al.   CLINICAL CANCER RESEARCH

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1

(2019) Na Zhang et al.   EBioMedicine

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Histamine and migraine revisited: mechanisms and possible drug targets

(2019) Jacob Worm et al.   JOURNAL OF HEADACHE AND PAIN

Collateral sensitivity of natural products in drug-resistant cancer cells

(2019) Thomas Efferth et al.   BIOTECHNOLOGY ADVANCES

Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma

(2019) Shuo Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Sequential Targeting TGF‐β Signaling and KRAS Mutation Increases Therapeutic Efficacy in Pancreatic Cancer

(2019) Yuanyuan Pei et al.   Small

Effective Radiotherapy in Tumor Assisted by Ganoderma lucidum Polysaccharide-Conjugated Bismuth Sulfide Nanoparticles through Radiosensitization and Dendritic Cell Activation

(2019) Huan Yu et al.   ACS Applied Materials & Interfaces

Inhibition of murine hepatoma tumor growth by cryptotanshinone involves TLR7-dependent activation of macrophages and induction of adaptive antitumor immune defenses

(2019) Zhen Han et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Unraveling the molecular mechanisms and the potential chemopreventive/therapeutic properties of natural compounds in melanoma

(2019) Fabrizio Fontana et al.   SEMINARS IN CANCER BIOLOGY

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

(2019) KEFAH MOKBEL et al.   ANTICANCER RESEARCH

Polysaccharides from Hedyotis diffusa enhance the antitumor activities of cytokine-induced killer cells

(2019) Chuanjiang Ma et al.   BIOMEDICINE & PHARMACOTHERAPY

Modulation of regulatory T cells by natural products in cancer

(2019) Afsane Bahrami et al.   CANCER LETTERS

Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer

(2019) Jing Zhang et al.   ACS Nano

Baicalein and baicalin promote antitumor immunity by suppressing PD-L1 expression in hepatocellular carcinoma cells

(2019) Mengyun Ke et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms Controlling PD-L1 Expression in Cancer

(2019) Jong-Ho Cha et al.   MOLECULAR CELL

Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response

(2019) Jian Liang et al.   PHARMACOLOGICAL RESEARCH

Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico

(2019) Candice Mazewski et al.   Scientific Reports

Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells

(2019) Yanke Zhang et al.   Infectious Agents and Cancer

Antitumor effects of immunity-enhancing traditional Chinese medicine

(2019) Yeshu Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation

(2019) Luoyang Wang et al.   JOURNAL OF IMMUNOLOGY

Modified Bu-zhong-yi-qi decoction synergies with 5 fluorouracile to inhibits gastric cancer progress via PD-1/PD- L1-dependent T cell immunization

(2019) Ruihan Xu et al.   PHARMACOLOGICAL RESEARCH

Triterpenoid Saponins from Anemone flaccida Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism

(2019) Lintao Han et al.   OncoTargets and Therapy

Astragalus Saponins and Liposome Constitute an Efficacious Adjuvant Formulation for Cancer Vaccines

(2018) Xiao-Ping Zhang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications

(2018) Gagan Chhabra et al.   CANCER LETTERS

Non-apoptotic cell death in malignant tumor cells and natural compounds

(2018) Jing Ye et al.   CANCER LETTERS

Dendrimers in combination with natural products and analogues as anti-cancer agents

(2018) Serge Mignani et al.   CHEMICAL SOCIETY REVIEWS

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

(2018) Alessandro Prestipino et al.   Science Translational Medicine

Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways

(2018) Ashley B. Ward et al.   World Journal of Surgical Oncology

Polysaccharides as vaccine adjuvants

(2018) Beini Sun et al.   VACCINE

FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia

(2018) Maura C. O’Leary et al.   CLINICAL CANCER RESEARCH

FDA Approval Summary: Axicabtagene Ciloleucel for Relapsed or Refractory Large B-cell Lymphoma

(2018) Najat Bouchkouj et al.   CLINICAL CANCER RESEARCH

Angelica sinensis polysaccharide encapsulated into PLGA nanoparticles as a vaccine delivery and adjuvant system for ovalbumin to promote immune responses

(2018) Pengfei Gu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of total glucosides of paeony on PD-1/PD-L1 expression in primary Sjögren's syndrome

(2018) Yueyue Chen et al.   International Journal of Rheumatic Diseases

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Diosgenin promotes antitumor immunity and PD-1 antibody efficacy against melanoma by regulating intestinal microbiota

(2018) Mengxue Dong et al.   Cell Death & Disease

Pyranonaphthoquinones – isolation, biology and synthesis: an update

(2017) Briar J. Naysmith et al.   NATURAL PRODUCT REPORTS

Natural products as mediators of disease

(2017) Neha Garg et al.   NATURAL PRODUCT REPORTS

New perspectives for natural triterpene glycosides as potential adjuvants

(2017) Marie-Aleth Lacaille-Dubois et al.   PHYTOMEDICINE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Nutrigenomics in cancer: Revisiting the effects of natural compounds

(2017) Cornelia Braicu et al.   SEMINARS IN CANCER BIOLOGY

Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model

(2017) Peng-Yang Hsu et al.   Oncotarget

Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis

(2016) Alberto Fernández-Tejada et al.   ACCOUNTS OF CHEMICAL RESEARCH

Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells

(2016) Melanie R. Power Coombs et al.   CANCER LETTERS

STAT3-targeted treatment with silibinin overcomes the acquired resistance to crizotinib in ALK-rearranged lung cancer

(2016) Elisabet Cuyàs et al.   CELL CYCLE

Talimogene Laherparepvec for the Treatment of Advanced Melanoma

(2016) P. A. Ott et al.   CLINICAL CANCER RESEARCH

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell–Vaccinated Mice

(2016) Pei-Ming Yang et al.   INTEGRATIVE CANCER THERAPIES

Neem leaf glycoprotein promotes dual generation of central and effector memory CD8 + T cells against sarcoma antigen vaccine to induce protective anti-tumor immunity

(2016) Sarbari Ghosh et al.   MOLECULAR IMMUNOLOGY

Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model

(2016) Yao Lu et al.   MOLECULAR THERAPY

Rekindling cancer vaccines

(2016) Malorye Allison Branca   NATURE BIOTECHNOLOGY

Immunogenic Cell Death Induced by Ginsenoside Rg3: Significance in Dendritic Cell-based Anti-tumor Immunotherapy

(2016) Keum-joo Son et al.   Immune Network

Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor- B to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer

(2015) J. Peng et al.   CANCER RESEARCH

FDA approves new upgraded Gardasil 9

(2015) Tony Kirby   LANCET ONCOLOGY

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression

(2015) Marisa Granato et al.   Oncotarget

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Neem Leaf Glycoprotein Prophylaxis Transduces Immune Dependent Stop Signal for Tumor Angiogenic Switch within Tumor Microenvironment

(2014) Saptak Banerjee et al.   PLoS One

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Effects and mechanisms of curcumin and basil polysaccharide on the invasion of SKOV3 cells and dendritic cells

(2013) JING LV et al.   Molecular Medicine Reports

Polysaccharides from Ganoderma formosanum function as a Th1 adjuvant and stimulate cytotoxic T cell response in vivo

(2013) Chia-Chen Pi et al.   VACCINE

Ethanol extract of Chaenomeles speciosa Nakai induces apoptosis in cancer cells and suppresses tumor growth in mice

(2013) GENDONG YAO et al.   Oncology Letters

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

(2012) Hui-Ming Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells

(2012) TAO HUANG et al.   ONCOLOGY REPORTS

Immunomodulation of Curcumin on Adoptive Therapy with T Cell Functional Imaging in Mice

(2011) Y.-F. Chang et al.   Cancer Prevention Research

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors

(2011) Seong-A Ju et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Saponins from the Spanish saffron Crocus sativus are efficient adjuvants for protein-based vaccines

(2011) Nathaly Castro-Díaz et al.   VACCINE

Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine

(2010) Chia-Hsin Huang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3 , C/EBP  and ATF3

(2010) S. H. Lee et al.   CARCINOGENESIS

Intracellular mechanisms of antigen cross presentation in dendritic cells

(2010) Sebastian Amigorena et al.   CURRENT OPINION IN IMMUNOLOGY

Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-γ by CD4+ naïve T cells

(2010) Tae-Young Jung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Design and Synthesis of PotentQuillajaSaponin Vaccine Adjuvants

(2010) Michelle M. Adams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Curcumin Potentiates the Antitumor Effects of Bacillus Calmette-Guerin against Bladder Cancer through the Downregulation of NF- B and Upregulation of TRAIL Receptors

(2009) A. M. Kamat et al.   CANCER RESEARCH

The effects of β-glucan on human immune and cancer cells

(2009) Godfrey Chan et al.   Journal of Hematology & Oncology

Advances in saponin-based adjuvants

(2009) Hong-Xiang Sun et al.   VACCINE

Neem leaf glycoprotein matures myeloid derived dendritic cells and optimizes anti-tumor T cell functions

(2009) Shyamal Goswami et al.   VACCINE

Effect and mechanism of ginsenoside Rg3 on postoperative life span of patients with non-small cell lung cancer

(2008) Ping Lu et al.   Chinese Journal of Integrative Medicine

Mast cells as regulators of adaptive immunity to tumours

(2008) A. Wasiuk et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Carthamus tinctoriusEnhances the Antitumor Activity of Dendritic Cell Vaccines via Polarization toward Th1 Cytokines and Increase of Cytotoxic T Lymphocytes

(2008) Jia-Ming Chang et al.   Evidence-based Complementary and Alternative Medicine

Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells

(2008) Young-Il Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY