Review
Immunology
Yanan Wu, Meng Yuan, Chenlin Wang, Yanfei Chen, Yan Zhang, Jiandong Zhang
Summary: T cells play a crucial role in lung cancer therapy, and understanding their functional mechanism can lead to the discovery and development of new treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ariana N. Renrick, Menaka C. Thounaojam, Maria Teresa P. de Aquino, Evan Chaudhuri, Jui Pandhare, Chandravanu Dash, Anil Shanker
Summary: The study demonstrates that bortezomib can enhance the function of anti-tumor CD8(+) T cells by inducing the downregulation of negative regulatory proteins SOCS1 and SHIP1 through the miR-155 pathway, thus overcoming T cell exhaustion in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuan Liang, Yezhen Tan, Bao Guan, Bin Guo, Mancheng Xia, Juan Li, Yue Shi, Zihui Yu, Qi Zhang, Di Liu, Xiaopeng Yang, Junfeng Hao, Yanqing Gong, Muhammad Shakeel, Liqun Zhou, Weimin Ci, Xuesong Li
Summary: This study investigates the response rate of upper tract urothelial carcinoma (UTUC) to immune checkpoint inhibitors (ICIs), compared with urothelial carcinoma of the bladder (UCB). The study finds that UTUC has a higher response rate to ICIs and a higher proportion of tumor-infiltrating immune cells. The study also reveals that immunosuppressive macrophages and exhausted T-cell subpopulations are enriched in the basal subtype of UTUC and show enhanced interactions.
Article
Oncology
Katarina Pinjusic, Olivier Andreas Dubey, Olga Egorova, Sina Nassiri, Etienne Meylan, Julien Faget, Daniel Beat Constam
Summary: This study reveals that Activin-A secretion by melanoma cells inhibits adaptive antitumor immunity by indirectly inhibiting CD8(+) T cell infiltration, regardless of BRAF status. It is also found that Activin-A/INHBA expression is correlated with resistance to anti-PD1 therapy in melanoma patients and impairs response to combination anti-cytotoxic T-Lymphocyte associated protein 4/anti-PD1 treatment in preclinical models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Qingda Wang, Yang Qin, Bo Li
Summary: Immunotherapy plays a crucial role in treating malignant tumors, and CD8+ T cells are essential for the success of immunotherapy. However, continuous antigen exposure and inflammatory factors can lead to CD8+ T cell exhaustion, causing loss of control and tumor progression. This review provides insights into the mechanisms and characteristics of CD8+ T cell exhaustion. While immunotherapy can reverse exhaustion and improve antitumor effects, single immunotherapy has limitations. The review also highlights promising clues for future management of malignant tumors.
Article
Oncology
Lingdi Yin, Yichao Lu, Cheng Cao, Zipeng Lu, Jishu Wei, Xiaole Zhu, Jianmin Chen, Feng Guo, Min Tu, Chunhua Xi, Kai Zhang, Junli Wu, Wentao Gao, Kuirong Jiang, Yi Miao, Qiang Li, Yunpeng Peng
Summary: This study integrates multiple datasets to explore the immune microenvironment of pancreatic cancer and identifies the correlation between CD8+ T cell infiltration and patient prognosis. Furthermore, it suggests that carbonic anhydrase 9 (CA9) may play a role in inhibiting CD8+ T cell infiltration and affecting the overall survival of pancreatic cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Maeoka, Ichiro Nakagawa, Takahiro Tsujimura, Ryosuke Matsuda
Summary: Glioblastoma (GBM) is an aggressive and malignant brain tumor with poor prognosis. Various treatment strategies have been explored, including immunotherapies. However, current immunotherapies mainly based on T cells have not achieved satisfactory outcomes. This review focuses on the potential of NK cell-based immunotherapy as a novel treatment strategy for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Siyuan Dai, Han Zeng, Zhaopei Liu, Kaifeng Jin, Wenbin Jiang, Zewei Wang, Zhiyuan Lin, Ying Xiong, Jiajun Wang, Yuan Chang, Qi Bai, Yu Xia, Li Liu, Yu Zhu, Le Xu, Yang Qu, Jianming Guo, Jiejie Xu
Summary: This study revealed the unfavorable clinical outcomes of CXCL13(+)CD8(+)T cells in patients with ccRCC and their impairment of the immune function of total CD8(+)T cells. In addition, CXCL13(+)CD8(+)T cells also showed increased exhausted markers, decreased effector molecules, and better proliferation ability, associated with an immunoevasive tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Barbara Ersek, Palma Sillo, Ugur Cakir, Viktor Molnar, Andras Bencsik, Balazs Mayer, Eva Mezey, Sarolta Karpati, Zoltan Pos, Krisztian Nemeth
Summary: This study demonstrates that melanoma-associated fibroblasts suppress the activity of cytotoxic T lymphocytes, with a key role played by arginase. It was found that in the presence of MAF-conditioned media, CTL activation was disrupted, leading to dysregulated signaling and upregulation of immune checkpoint receptors. This interference is mediated by soluble factors and l-arginine depletion, ultimately resulting in CTL anergy and immune checkpoint modulation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Ravikumar Muthuswamy, A. J. Robert McGray, Sebastiano Battaglia, Wenjun He, Anthony Miliotto, Cheryl Eppolito, Junko Matsuzaki, Tsuji Takemasa, Richard Koya, Thinle Chodon, Brian D. Lichty, Protul Shrikant, Kunle Odunsi
Summary: Resident memory CD8 T cells, characterized by their ability to reside in peripheral tissues, play a crucial role in adaptive sentinel activity and amplifying immune responses. The study focused on the chemotactic mechanisms governing the localization, retention, and residency of memory CD8 T cells in the ovarian tumor microenvironment. Results indicated that CXCR6 is a key marker for resident memory tumor-specific CD8 T cells, with its deficiency resulting in reduced retention in tumor tissues and poor control of ovarian cancer. Further research is needed to explore the potential of utilizing CXCR6 to enhance resident memory responses in cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Hongquan Qin, Jiali Chen, Katia Bouchekioua-Bouzaghou, Ya-Ming Meng, Jordi Bach Griera, Xue Jiang, Xiangzhan Kong, Minghui Wang, Qiuping Xu, Ping-Pui Wong
Summary: The study found that MAGEA regulates tumor-stromal crosstalk in PDAC, with high expression correlating with poor chemotherapeutic response and prognosis in multiple cancers. The mechanism includes inhibition of gemcitabine-induced cancer cell apoptosis and activation of GDF15 secretion to enhance gemcitabine resistance. Targeting MAGEA-mediated paracrine regulation of chemoresistance by immunotherapy could be a promising strategy for pancreatic cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Ying Zhang, Hui-Hui Hu, Shi-Hong Zhou, Wu-Yan Xia, Yan Zhang, Jian-Ping Zhang, Xiao-Long Fu, Wen Yu
Summary: This study investigated the dynamics of CD8(+) T cell infiltration and exhausted subpopulations after ablative irradiation, finding that 3-7 days post-irradiation might be an appropriate time window for immune checkpoint inhibitor (ICI) treatment. A PET radiomics approach was developed to differentiate T cell exhaustion status and visualize the association between heterogeneous texture on PET images and progressed T cell exhaustion.
BIOMARKER RESEARCH
(2023)
Article
Oncology
Sarah A. O'Brien, Jessica Orf, Katarzyna M. Skrzypczynska, Hong Tan, Jennie Kim, Jason DeVoss, Brian Belmontes, Jackson G. Egen
Summary: The study found that while anti-CSF1R treatment can reduce the number of tumor-associated macrophages (TAMs), it has minimal impact on the anti-tumor immune response in established tumors. In contrast, anti-CSF1R treatment concurrent with tumor implantation can better inhibit tumor growth and enhance anti-tumor immunity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cell Biology
Juanjuan Yuan, Ting Cai, Xiaojun Zheng, Yangzi Ren, Jingwen Qi, Xiaofei Lu, Huihui Chen, Huizhen Lin, Zijie Chen, Mengnan Liu, Shangwen He, Qijun Chen, Siyang Feng, Yingjun Wu, Wei Yang, Yanqing Ding, Zhenhai Zhang
Summary: The study reveals the crucial role of LDLR in regulating the antitumor activity of CD8(+) T cells, including promoting T cell priming and clonal expansion, as well as regulating TCR signaling through interaction with the TCR complex. Moreover, the tumor microenvironment suppresses LDLR and TCR signaling in CD8(+) T cells via PCSK9, inhibiting the effector function of CTLs.
Article
Oncology
Anze Yu, Jiao Hu, Liangmin Fu, Gaowei Huang, Dingshan Deng, Mingxiao Zhang, Yinghan Wang, Guannan Shu, Lanyu Jing, Huihuang Li, Xu Chen, Taowei Yang, Jinhuan Wei, Zhenhua Chen, Xiongbing Zu, Junhang Luo
Summary: This study demonstrates that LRFN2 plays an immunosuppressive role in bladder cancer by reducing the secretion of pro-inflammatory cytokines and chemokines, thus inhibiting the recruitment and functional transition of CD8(+) T cells. LRFN2 restrains antitumor immunity by inhibiting the infiltration, proliferation, and differentiation of CD8(+) T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
