Article
Environmental Sciences
Fuyang Jiang, Qiyue Jiang, Jing Zhao, Zhonghui Zhu, Qiyue Jia, Wenming Xue, Hongwei Wang, Yan Wang, Lin Tian
Summary: Silica can induce macrophage pyroptosis, which plays an important role in activating myofibroblasts during the progression of silicosis. Inhibiting macrophage pyroptosis could be a feasible clinical strategy to alleviate silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Lee M. Booty, Clare E. Bryant
Summary: The discovery of pyroptosis and its implications in infection and immunity has provided new insights into host defense against pathogens. However, the regulation of pyroptosis is complex and varies between cell types, stimulation conditions, pathogens, and animal species. Excessive inflammation caused by pyroptosis contributes to the development of sepsis. Understanding the regulation of pyroptotic pathways is crucial for identifying potential therapeutic targets for sepsis.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuanhua Lu, Jianan Zhao, Yafei Tian, Dan Shao, Zhiqi Zhang, Siqi Li, Jialin Li, Hugang Zhang, Wei Wang, Ping Jiao, Jie Ma
Summary: The study demonstrates that Men1 has conflicting roles in pulmonary fibrosis, as it attenuates fibrosis by inhibiting fibroblast activation and promoting macrophage fibrotic phenotype and migration. The profibrotic role of Men1 in macrophages may be mediated by regulating macrophage pyroptosis and OPN expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura
Summary: GSDMD and GSDME, members of the gasdermin protein family, are involved in the formation of plasma membrane channels contributing to cell rupture during a certain type of necrosis called pyroptosis. This study found that the expression of the GSDMD gene increases significantly during LPS-induced pyroptosis, while GSDME expression decreases. Additionally, glucose availability was found to be important for the increasing effect of LPS on GSDMD expression.
Article
Pharmacology & Pharmacy
Mengqing Jiang, Xuejing Sun, Suzhen Liu, Yan Tang, Yunming Shi, Yuanyuan Bai, Yujie Wang, Qiong Yang, Qize Yang, Weihong Jiang, Hong Yuan, Qixia Jiang, Jingjing Cai
Summary: The study shows that oxidized phospholipids can induce pyroptosis via noncanonical inflammasome activation, promoting the development of atherosclerosis. Further experiments demonstrate that inflammatory signaling mediated by caspase-11 and gasdermin D is significantly activated in peripheral blood mononuclear cells from patients with coronary heart disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ningyi Wan, Jing Shi, Jianguo Xu, Juan Huang, Delu Gan, Min Tang, Xiaohan Li, Ying Huang, Pu Li
Summary: This review provides an overview of the major activation mechanisms and effector pathways of GSDMD, discusses its importance and role in different diseases, and explores its potential in diagnosis, early detection, and prognosis assessment. Furthermore, the review proposes new directions for further research into GSDMD.
Article
Biochemistry & Molecular Biology
Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cedric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Summary: GSDMD plays a critical role in atherosclerotic plaque destabilization, with its deficiency leading to increased plaque stability and apoptosis. Targeting GSDMD may be an effective approach to limit the transition to an inflammatory, vulnerable plaque phenotype.
Article
Environmental Sciences
Qiong Tang, Chen Xing, Ming Li, Qiang Jia, Cunxiang Bo, Zhenling Zhang
Summary: This study investigated the mechanism by which Pirfenidone ameliorates fibrosis in silicosis using a rat model. The results showed that Pirfenidone reduced pulmonary fibrosis by inhibiting macrophage polarization and decreasing the expression of fibrosis-related markers.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Toxicology
Huihui Tao, Hui Zhao, Deyong Ge, Jinjun Liao, Luocheng Shao, Aowei Mo, LeLin Hu, Keyi Xu, Jing Wu, Min Mu, Bin Li, Xinrong Tao, Jianhua Wang
Summary: The necroptotic signaling pathway of macrophages is significantly activated in the lungs of silicosis mouse models, promoting the progression of silicosis through enhancing lung inflammatory responses and fibrogenesis. Increased M1 macrophage infiltration and up-regulation of pro-inflammatory cytokines were observed in this study, along with the up-regulation of pro-fibrotic factors and fibrosis biomarkers, which were recovered by the specific inhibitor of RIP1 kinase-dependent necroptosis. These findings provide new insights for the treatment of silicosis.
TOXICOLOGY LETTERS
(2022)
Review
Pharmacology & Pharmacy
Jiabing Wang, Jiali Yao, Yugang Liu, Lili Huang
Summary: Stroke, a major cause of death and disability, leads to neuroinflammation which can be targeted for therapeutic interventions. Pyroptosis, a form of programmed cell death, involves GSDMD as a key player in triggering inflammatory responses and cell death in ischemic stroke. Understanding the role of GSDMD may provide new insights for novel therapeutic strategies.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jian Zhou, Yali Chen, Menglin He, Xuehan Li, Rurong Wang
Summary: This article comprehensively summarizes the alteration and functional role of circRNAs in pulmonary fibrosis and discusses the diagnostic and therapeutic potential of targeting circRNAs and their regulatory pathway mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Katherine C. Barnett, Yuying Xie, Takanori Asakura, Dingka Song, Kaixin Liang, Sharon A. Taft-Benz, Haitao Guo, Shuangshuang Yang, Kenichi Okuda, Rodney C. Gilmore, Jennifer F. Loome, Thomas H. Oguin III, Gregory D. Sempowski, Scott H. Randell, Mark T. Heise, Yu Leo Lei, Richard C. Boucher, Jenny P. -Y. Ting
Summary: Elevated levels of cytokines IL-1(3 and IL-6 are associated with severe COVID-19. Investigating the underlying mechanisms, it was found that primary human airway epithelia (HAE) are not the source of IL-1(3 released upon SARS-CoV-2 infection. The SARS-CoV-2 E protein upregulates inflammasome gene transcription via TLR2 in leukocytes, while infected HAE supply a second signal, including genomic and mitochondrial DNA, to stimulate leukocyte IL-1(3 release.
CELL HOST & MICROBE
(2023)
Article
Cell Biology
Biyang Jiao, Qianyi Zhang, Chunmeng Jin, Hongmin Yu, Qiuyun Wu
Summary: This study revealed the upregulation of IRF4 in fibrotic lung tissues of mice exposed to silica particles and verified the increased expression of IRF4 in SiO2-treated macrophages and TGF-beta 1-treated fibroblasts. The down-regulation of IRF4 impeded macrophage polarization and the release of pro-fibrotic factors, as well as alleviated migration, invasion, and the expression of fibrotic molecules in fibroblasts. IRF4 was found to regulate the transcriptional activity of the IL-17A promoter, stimulating fibroblast activation, migration, and invasion. In vivo experiments showed that IRF4 knockdown alleviated the fibrotic responses in mouse lung tissues.
Article
Pharmacology & Pharmacy
Fei Geng, Mengying Xu, Lan Zhao, Haoming Zhang, Jiarui Li, Fuyu Jin, Yaqian Li, Tian Li, Xinyu Yang, Shifeng Li, Xuemin Gao, Wenchen Cai, Na Mao, Ying Sun, Heliang Liu, Hong Xu, Zhongqiu Wei, Fang Yang
Summary: Quercetin reduces pulmonary fibrosis by inhibiting macrophage senescence and regulates the expression of senescence-associated secretory phenotype (SASP).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Ya-Qian Li, Xu-Liang An, Fu-Yu Jin, Yi-Fei Bai, Tian Li, Xin-Yu Yang, Shu-Peng Liu, Xue-Min Gao, Na Mao, Hong Xu, Wen-Chen Cai, Fang Yang
Summary: The effects of integrated stress response inhibitor (ISRIB) on cellular senescence and pulmonary fibrosis in silicosis were evaluated. ISRIB significantly reduced the degree of pulmonary fibrosis and reversed the expression of senescence-related factors in mice with silicosis. These findings suggest that ISRIB may alleviate pulmonary fibrosis in silicosis by inhibiting cellular senescence.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Zhu-jie Cao, Ying Liu, Zhe Zhang, Pei-ran Yang, Zhao-guo Li, Mei-yue Song, Xian-mei Qi, Zhi-fa Han, Jun-ling Pang, Bai-cun Li, Xin-ri Zhang, Hua-ping Dai, Jing Wang, Chen Wang
Summary: Pirfenidone has been demonstrated to effectively ameliorate silica-induced lung dysfunction, pulmonary inflammation, and fibrosis in mouse models by inhibiting the secretion of IL-17A, showing potential as a treatment for both early and advanced silicosis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Multidisciplinary
Mei-yue Song, Jia-xin Wang, You-liang Sun, Zhi-fa Han, Yi-tian Zhou, Ying Liu, Tian-hui Fan, Zhao-guo Li, Xian-mei Qi, Ya Luo, Pei-ran Yang, Bai-cun Li, Xin-ri Zhang, Jing Wang, Chen Wang
Summary: This study established silicosis mouse models to investigate the effectiveness of tetrandrine in early and late therapeutic administration, revealing its novel mechanism of attenuating silicosis by inhibiting the NLRP3 inflammasome pathways in lung macrophages. The findings not only demonstrated promising results against silicosis-associated inflammation and fibrosis, but also laid the groundwork for understanding the molecular targets of tetrandrine, potentially leading to a globally accepted therapeutic strategy for silicosis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Meteorology & Atmospheric Sciences
Yingying An, Xianhong Meng, Lin Zhao, Zhaoguo Li, Shaoying Wang, Lunyu Shang, Hao Chen, Shihua Lyu
Summary: Surface albedo plays a crucial role in the energy and water cycles, and the parameterizations of surface albedo greatly impact the simulation of radiation partition in climate models. In this study, in-situ measurements and MODIS albedo product were used to evaluate the simulated surface albedo by 24 Global Climate Models. The results showed varying monthly albedo among models, with the ensemble mean closer to in-situ measurements. Some models exhibited significant biases in annual surface albedo cycle, and snow albedo parameterization schemes varied in fitting snow albedo attenuation over time in all models.
INTERNATIONAL JOURNAL OF CLIMATOLOGY
(2022)
Correction
Agronomy
Yuyang Wang, Jingfeng Xiao, Yaoming Ma, Yiqi Luo, Zeyong Hu, Fu Li, Yingnian Li, Lianglei Gu, Zhaoguo Li, Ling Yuan
Summary: The study compared spatial variations of carbon fluxes in different types of alpine ecosystems, finding that alpine meadow ecosystems are controlled by soil temperature, while alpine grasslands are controlled by soil moisture.
AGRICULTURAL AND FOREST METEOROLOGY
(2022)
Article
Environmental Sciences
Jibin Ning, Guang Yang, Xinyuan Liu, Daotong Geng, Lixuan Wang, Zhaoguo Li, Yunlin Zhang, Xueying Di, Long Sun, Hongzhou Yu
Summary: In this study, relationships between PM2.5 concentration and environment and fuel characteristics were examined through laboratory experiments. Fire line intensity and flame width were found to have the strongest association with PM2.5 concentration. Regression models were built to predict PM2.5 and fire line intensity, with high accuracy.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Meteorology & Atmospheric Sciences
Yumeng Liu, Xianhong Meng, Lin Zhao, Zhaoguo Li, Hao Chen, Lunyu Shang, Shaoying Wang, Lele Shu, Guangwei Li
Summary: Under the intensification of global warming, the characteristics of the Three Rivers source region in China were diagnosed using observations and reanalysis data. The study found significant interdecadal variability in summer precipitation in this region, with a noticeable increase after 2002, which was strongly associated with the interdecadal position and intensity of the East Asian westerly jet. The study also revealed a negative correlation between the position index of the East Asian westerly jet and precipitation in the Three Rivers source region.
JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY
(2022)
Article
Environmental Sciences
Mingshan Deng, Xianhong Meng, Yaqiong Lu, Zhaoguo Li, Lin Zhao, Hanlin Niu, Hao Chen, Lunyu Shang, Shaoying Wang, Danrui Sheng
Summary: Changes in vegetation dynamics are crucial for terrestrial ecosystems and environments. This study revised and validated a land surface biogeochemical dynamic vegetation model for the Tibetan Plateau, and found that temperature warming and precipitation enhancement are the dominant factors for increased vegetation productivity.
Article
Chemistry, Physical
Jia Li, Xi Yang, Lei Yuan, Zhaoguo Li, Yong Zeng, Hao Shen
Summary: In this study, the gelation process of resorcinol and formaldehyde (RF) was analyzed using various analytical techniques. The results provided insights into the molecular dynamics of RF gelation, including particle size changes, gel formation time, and dipole moment changes. The effects of RF reaction solution concentration and growth temperature were also investigated, providing guidelines for controlling the gelation process and obtaining stable RF gels.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Environmental Sciences
Yiling Chen, Meiyue Song, Zhaoguo Li, Lin Hou, Hong Zhang, Zhe Zhang, Huiyuan Hu, Xuehan Jiang, Jie Yang, Xuan Zou, Junling Pang, Tiantian Zhang, Peiran Yang, Jing Wang, Chen Wang
Summary: This study suggests that the FceRI gene is associated with the pathogenesis of silicosis and may serve as a potential therapeutic target.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Polymer Science
Zhiqing Wu, Fan Lei, Zhiqiang Zhan, Jiangshan Luo, Gao Niu, Zhaoguo Li, Tao Yi, Shufan Chen, Bo Yang, Qiubo Fu, Zhiming Zhang
Summary: The exploding foil initiator (EFI) system is widely used in ignition and detonation sequences due to its high safety and reliability. In this study, an EFI based on a polyimide (ODPA-ODA) flyer was prepared and its performance and chemical structure were analyzed. The experimental results showed that the prepared EFI had good working performance and achieved a high velocity in the electric explosion test.
Article
Meteorology & Atmospheric Sciences
Mingshan Deng, Xianhong Meng, Yaqiong Lu, Lele Shu, Zhaoguo Li, Lin Zhao, Hao Chen, Lunyu Shang, Danrui Sheng, Xinmao Ao
Summary: This study evaluated the impacts of regional climate and vegetation change on runoff in the Three Rivers Source Region (TRSR). The results showed that precipitation was the dominant factor affecting runoff and evapotranspiration (ET), while temperature had a relatively small contribution to runoff. Vegetation change had a significant impact on runoff, and the Dynamic Global Vegetation Model (DGVM) effectively simulated the changes in vegetation and runoff.
Article
Environmental Sciences
Zhaoguo Li, Shaobo Zhang, Xianhong Meng, Shihua Lyu, Xianyu Yang, Yinhuan Ao, Di Ma, Lunyu Shang, Lele Shu, Yan Chang
Summary: Extreme snowfall events have been increasing in the Tibetan Plateau and have caused greater variations in snow cover conditions. This study analyzed the impacts of snow cover on water-heat transfer in alpine meadows using five years of observation data. The findings indicate that snow cover decreases soil temperature and inhibits extremely low temperatures in the soil. Different snow conditions also affect soil thawing, snowmelt infiltration, and surface soil water evaporation. The study provides insights into soil water-heat transfer under extreme snow cover conditions in the Tibetan Plateau.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yuxuan Wang, Yinhuan Ao, Zhaoguo Li
Summary: Evapotranspiration plays a crucial role in maintaining the ecological stability of oases and is influenced by irrigation and urbanization expansion. By analyzing the spatial and temporal characteristics of evapotranspiration in Zhangye Oasis, Jinta Oasis, and Ejina Oasis, it is found that there are differences in evapotranspiration intensity among different oases, and urbanization expansion leads to a decrease in evapotranspiration intensity in oases.
Article
Meteorology & Atmospheric Sciences
Di Ma, Xianhong Meng, Shihua Lv, Yaohui Li, Haipeng Yu, Lele Shu, Lin Zhao, Zhaoguo Li
Summary: This paper investigates the local and non-local climatic effects of wetter arid areas of Northwestern China (ANWC) in summer using a fully coupled climate model. The results show that with increasing soil moisture, the local air temperature decreases significantly and precipitation increases during summer. The wetter ANWC leads to a warmer and rainless climate over the Central part of North China Plain (CNCP), while its influence on Tibetan Plateau (TP) precipitation is negligible due to the high altitude.
ATMOSPHERIC RESEARCH
(2023)
Article
Geography, Physical
Mengxiao Wang, Lijuan Wen, Zhaoguo Li, Matti Lepparanta, Victor Stepanenko, Yixin Zhao, Ruijia Niu, Liuyiyi Yang, Georgiy Kirillin
Summary: The seasonal ice cover in lakes of the Qinghai-Tibet Plateau is a vulnerable part of the cryosphere that is influenced by regional climate. This study focuses on the mechanism of solar thermal accumulation under ice using temperature observations from Ngoring Lake and a lake model. The results show that solar radiation is the main source of under-ice warming, and the accumulated heat has a delayed effect on land-atmosphere heat exchange.
