ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation

Ipriflavone as a non‐steroidal glucocorticoid receptor antagonist ameliorates diabetic cognitive impairment in mice

(2022) Ruifang Nie et al.   AGING CELL

Role of polyunsaturated fatty acids in ischemic stroke – A perspective of specialized pro-resolving mediators

(2021) Zhijuan Miao et al.   CLINICAL NUTRITION

The role of mitophagy in the regulation of mitochondrial energetic status in neurons

(2021) Sinsuk Han et al.   Autophagy

Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice

(2021) Jiawei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective Effects of Chemerin on a Mouse Stroke Model: Behavioral and Molecular Dimensions

(2021) Azam Abareshi et al.   NEUROCHEMICAL RESEARCH

Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23

(2021) Hiroe Suzuki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Role of chemerin in the control of glucose homeostasis

(2021) A. Léniz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Energy matters: presynaptic metabolism and the maintenance of synaptic transmission

(2021) Sunan Li et al.   NATURE REVIEWS NEUROSCIENCE

Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level

(2021) Abrar E. Al-Shaer et al.   Frontiers in Nutrition

Receptors for pro‐resolving mediators are increased in Alzheimer's disease brain

(2020) Ceren Emre et al.   BRAIN PATHOLOGY

RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome

(2020) Eric D. Hamlett et al.   GLIA

TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

(2020) Jiawei Zhang et al.   Journal of Neuroinflammation

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

(2020) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

(2020) Zhigang Liu et al.   Nature Communications

Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease through the Resolvin E1 and ChemR23 Axis

(2020) Gonzalo Artiach et al.   CIRCULATION

Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress

(2020) Xiao-Li Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The chemokine-like receptor 1 deficiency improves cognitive deficits of AD mice and attenuates tau hyperphosphorylation via regulating tau seeding

(2020) Haibo Zhang et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Electron Transport: Oxidative Phosphorylation, Mitochondrial Oxidant Production, and Methods of Measurement

(2020) Deirdre Nolfi-Donegan et al.   Redox Biology

Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic–ischemic encephalopathy

(2019) Yixin Zhang et al.   Cell Death & Disease

HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

(2019) Qiuchen Zhao et al.   Journal of Neuroinflammation

Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice

(2019) Kexin Wang et al.   MEDIATORS OF INFLAMMATION

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

(2019) Gahee Bahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189

(2019) Corinne G. Jolivalt et al.   DIABETES

The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis

(2019) Wenhui Yan et al.   LIFE SCIENCES

Chemerin-induced macrophages pyroptosis in fetal brain tissue leads to cognitive disorder in offspring of diabetic dams

(2019) Zhaoxia Liang et al.   Journal of Neuroinflammation

Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1–42-Induced Object Memory Impairment in Mice

(2019) ZeLin Lei et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

(2018) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice

(2018) Jinchun Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats

(2018) Yixin Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

(2018) Alpdogan Kantarci et al.   EXPERIMENTAL NEUROLOGY

Chemerin: a multifaceted adipokine involved in metabolic disorders

(2018) Gisela Helfer et al.   JOURNAL OF ENDOCRINOLOGY

Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice

(2018) Zhanyang Yu et al.   MOLECULAR NEUROBIOLOGY

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

(2018) Yadong Zhai et al.   MOLECULES

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

(2018) Geert Jan Biessels et al.   Nature Reviews Endocrinology

Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice

(2018) Hong-Ying Li et al.   REJUVENATION RESEARCH

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2018) Yadong Zhai et al.   Oncotarget

Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes

(2018) Corneliu Sima et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice

(2018) Tianyuan Ye et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin resistance: Review of the underlying molecular mechanisms

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

(2017) Justin T. Rogers et al.   NEUROBIOLOGY OF AGING

Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons

(2017) Marco Antonio Zaragoza-Campillo et al.   Oxidative Medicine and Cellular Longevity

International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function

(2017) Amanda J. Kennedy et al.   PHARMACOLOGICAL REVIEWS

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23

(2017) Satoshi Deyama et al.   PSYCHOPHARMACOLOGY

The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise

(2016) Ming Cai et al.   BRAIN BEHAVIOR AND IMMUNITY

Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity

(2016) Xia Tian et al.   BRAIN RESEARCH

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes

(2016) Marcelo O. Freire et al.   JOURNAL OF IMMUNOLOGY

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models

(2016) Stuart A Lipton et al.   Cell Death & Disease

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through NoxNovelty and Significance

(2015) Karla Bianca Neves et al.   HYPERTENSION

Diabetes in Midlife and Cognitive Change Over 20 Years

(2014) Andreea M. Rawlings et al.   ANNALS OF INTERNAL MEDICINE

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nrf2 induces fibroblast growth factor 21 in diabetic mice

(2014) Yuki Furusawa et al.   GENES TO CELLS

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Nrf2 Protects Pancreatic  -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

(2013) Y. Yagishita et al.   DIABETES

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Neurodegeneration in Streptozotocin-Induced Diabetic Rats Is Attenuated by Treatment with Resveratrol

(2013) Yu-Hong Jing et al.   NEUROENDOCRINOLOGY

Spatial memory impairments in a prediabetic rat model

(2013) E. Soares et al.   NEUROSCIENCE

Diabetes and cognitive dysfunction

(2012) Rory J McCrimmon et al.   LANCET

Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism

(2011) Benjamin Bondue et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Ginkgo Biloba Extract Ameliorates Oxidative Phosphorylation Performance and Rescues Aβ-Induced Failure

(2010) Virginie Rhein et al.   PLoS One

Chemerin: at the crossroads of inflammation and obesity

(2010) Matthew C. Ernst et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mouse ChemR23 Is Expressed in Dendritic Cell Subsets and Macrophages, and Mediates an Anti-Inflammatory Activity of Chemerin in a Lung Disease Model

(2009) S. Luangsay et al.   JOURNAL OF IMMUNOLOGY

Subclinical inflammation/oxidation as revealed by altered gene expression profiles in subjects with impaired glucose tolerance and Type 2 diabetes patients

(2009) Kuppan Gokulakrishnan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

(2008) Sang Won Suh et al.   ANNALS OF NEUROLOGY

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemerin reveals its chimeric nature: Figure 1.

(2008) Teizo Yoshimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synthetic chemerin-derived peptides suppress inflammation through ChemR23

(2008) Jenna L. Cash et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

(2008) Alexis M Stranahan et al.   NATURE NEUROSCIENCE